4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
![4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Structure](CAS/20200119/GIF/310460-39-0.gif)
- CAS No.
- 310460-39-0
- Chemical Name:
- 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
- Synonyms
- CPYPP;CPYPP, 10 mM in DMSO;4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione;4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 4-[3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-;DOCK2,CPYPP,Inhibitor,GEF,Rac1,DOCK180,lymphocytes,autoimmune,DOCK2-Rac1,inhibit,DOCK5,immunosuppressant,migration
- CBNumber:
- CB34902763
- Molecular Formula:
- C18H13ClN2O2
- Molecular Weight:
- 324.76
- MDL Number:
- MOL File:
- 310460-39-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4568 | CPYPP ≥98%(HPLC) | 310460-39-0 | 10 | $115 | 2021-12-16 | Buy |
| Tocris | 4568 | CPYPP ≥98%(HPLC) | 310460-39-0 | 50 | $482 | 2021-12-16 | Buy |
| TRC | C781505 | CPYPP | 310460-39-0 | 5mg | $220 | 2021-12-16 | Buy |
| Ambeed | A1226465 | 4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione 97% | 310460-39-0 | 25mg | $106 | 2021-12-16 | Buy |
| Ambeed | A1226465 | 4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione 97% | 310460-39-0 | 50mg | $152 | 2021-12-16 | Buy |
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Chemical Properties,Uses,Production
Uses
CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 μM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9[1].
in vivo
When 2.5 mg/kg of CPYPP is administrated intravenously, the plasma concentration of CPYPP is only 2.4 μM at 30 min. However, by intraperitoneally injecting 250 mg/kg of CPYPP into mice, the plasma concentration of CPYPP reached to 11.3 μM at 30 min and 10.9 μM at 1 hr, respectively[1].
?
The adoptively transferred spleen cells from mice that has been made by a ‘‘knock-in’’ strategy to express endogenous DOCK2 as a fusion protein with green fluorescent protein (GFP). Intraperitoneal injection of CPYPP (5 mg per mouse) 1 hr before adoptive transfer reduces the percentage of the migrated T cells to <25% of the control level[1].
storage
Store at -20°C
References
[1] Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97. DOI:10.1016/j.chembiol.2012.03.008
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6439 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1991 | 58 |
