CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
- CAS No.
- 92285-01-3
- Chemical Name:
- CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
- Synonyms
- Ajoene;E/Z Ajoene;CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-;(Z)-4,5,9-Trithiadodeca-1,6,11-triene-9-oxide;2-Propenyl(4,5-dithia-2,7-octadiene-1-yl) sulfoxide;2-Propenyl 3-(2-propenylsulfinyl)-1-propenyl persulfide;Allyl[(2E)-3-(allyldisulfanyl)-2-propen-1-yl]sulfoniumolate;(2-Propenyl)[3-[(2-propenyl)sulfinyl]-1-propenyl] persulfide;(Z)-1-(prop-2-enyldisulfanyl)-3-prop-2-enylsulfinylprop-1-ene;Disulfide, 2-propen-1-yl [3-(2-propen-1-ylsulfinyl)-1-propen-1-yl]
- CBNumber:
- CB3497346
- Molecular Formula:
- C9H14OS3
- Molecular Weight:
- 234.4
- MDL Number:
- MFCD06411561
- MOL File:
- 92285-01-3.mol
| Boiling point | 376.0±42.0 °C(Predicted) |
|---|---|
| Density | 1.181±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | Chloroform: slightly soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble |
| form | Liquid |
| color | Colorless to light yellow |
| LogP | 2.536 (est) |
| FDA UNII | 99A0041VG8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26242 | Ajoene | 92285-01-3 | 2.5mg | $275 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0015045 | AJOENE 95.00% | 92285-01-3 | 5MG | $500.7 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 67692 | E/ZAjoene | 92285-01-3 | 2.5mg | $590 | 2021-12-16 | Buy |
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Chemical Properties,Uses,Production
Uses
Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2].
Definition
ChEBI: (E)-Ajoene is a sulfoxide.
Anticancer Research
It is an organosulfur compound obtained from garlic and induces apoptosis in leukemiacells (Aggarwal and Shishodia 2004). Ajoene demonstrated a significantcytotoxic activity in different cancer cell lines including FS4 (human primaryfibroblast), BHK21 (a permanent and non-tumorigenic cell line derived from kidneycells of baby hamster), and BJA-B (tumorigenic lymphoid cell line derived fromBurkitt lymphoma) (Scharfenberg et al. 1990)
in vivo
Ajoene (25 μg/g body weight of Ajoene in 100 mL Intralipid; i.p.; every other day from the day of inoculation up to day 28) inhibits both primary tumor growth[1].
Ajoene (25, 15 or 5 μg/g body weight of Ajoene in 100 μL Intralipid; i.p; every other day over 4 weeks) inhibits strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice[1].
References
[1] Taylor P, et al. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 2006;239(2):298-304. DOI:10.1016/j.canlet.2005.08.022
[2] Ahmed N, et al. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001;21(5):3519-3523. PMID:11848518
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Preparation Products And Raw materials
Raw materials
Preparation Products
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3061 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9450 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5173 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Hubei yongkuo Technology Co., Ltd | 027-59223108 15972152991 | 1248580099@qq.com | China | 9979 | 58 |
