HISPIDIN
- CAS No.
- 555-55-5
- Chemical Name:
- HISPIDIN
- Synonyms
- Hispidine;Hispidin, 10 mM in DMSO;Hispidin - CAS 555-55-5 - Calbiochem;6-(3,4-Dihydroxystyryl)-4-hydroxy-2-pyrone;6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one;(E)-6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one;4-hydroxy-6-(3,4-dihydroxystyryl)-2-pyrone (hispidine);2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-4-pyranone;6-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]-4-hydroxy-2H-pyran-2-one;(E)-6-[2-(3,4-Dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
- CBNumber:
- CB3500046
- Molecular Formula:
- C13H10O5
- Molecular Weight:
- 246.22
- MDL Number:
- MFCD22199534
- MOL File:
- 555-55-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 312-315℃ |
|---|---|
| Boiling point | 500.5±50.0 °C(Predicted) |
| Density | 1.657 |
| storage temp. | -20°C |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| pka | 4.90±0.30(Predicted) |
| color | yellow to brown |
| biological source | synthetic (organic) |
| λmax | 369nm(MeOH)(lit.) |
| InChI | 1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+ |
| InChIKey | SGJNQVTUYXCBKH-HNQUOIGGSA-N |
| SMILES | OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O |
| FDA UNII | SSJ18CG55E |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2932.20.3000 |
| Storage Class | 11 - Combustible Solids |
HISPIDIN price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H5257 | Hispidin solid, ≥98% (HPLC) | 555-55-5 | 5mg | $459 | 2026-04-30 | Buy |
| Sigma-Aldrich | 377980 | Hispidin | 555-55-5 | 2mg | $419 | 2023-01-07 | Buy |
| TCI Chemical | H1661 | Hispidin >98.0%(HPLC) | 555-55-5 | 10mg | $348 | 2026-04-30 | Buy |
| TCI Chemical | H1661 | Hispidin >98.0%(HPLC) | 555-55-5 | 50mg | $1042 | 2026-04-30 | Buy |
| Cayman Chemical | 10012605 | Hispidin ≥95% | 555-55-5 | 1mg | $103 | 2026-04-30 | Buy |
HISPIDIN Chemical Properties, Uses, Production
Description
Hispidin is a polyphenol originally isolated from P. hispidus that has diverse biological activities, including antioxidant, anti-inflammatory, and cytoprotective properties. In a trolox equivalent antioxidant capacity (TEAC) assay, hispidin scavenges radicals at 14.47 equivalents of trolox . It inhibits transcriptional activity of NF-κB, decreases inducible nitric oxide synthase (iNOS) expression, and decreases the generation of reactive oxygen species (ROS) in LPS-induced macrophage RAW 264.7 cells. Hispidin inhibits apoptosis and increases insulin secretion in hydrogen peroxide-treated RINm5F pancreatic β-cells. It inhibits protein kinase C β (PKCβ; IC50 = 2 μM) with no activity against alkaline phosphatase. Hispidin also inhibits β-secretase (BACE1; IC50 = 4.9 μM) and prolyl endopeptidase (PE; IC50 = 16 μM) but not other serine proteases when used at a concentration of 40 μM (0.6, 0, 8.2, and 3.1% inhibition of chymotrypsin, trypsin, elastase, and tumor necrosis factor-α converting enzyme (TACE), respectively).
Uses
Hispidin is a naturally occuring precursor to fungal luciferin responsible for luminosity in mushrooms.
Definition
ChEBI: Fungal metabolite first found in basidiomycete Inonotus hispidus (formerly Polyporus hispidus).
General Description
Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.
Biochem/physiol Actions
Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
in vitro
in previous study hispidin was found to reduce cell viability in both mouse and human colon cancer cells, and the apoptotic cell morphological changes were also observed. these results showed accumulation of the sub-g1 cell population and increase in early apoptosis dose-dependently. moreover, hispidin could induce apoptosis via up-regulation of both intrinsic and extrinsic apoptotic pathways. although the molecular mechanism underlying hispidin-induced apoptosis was known to involve the generation of ros, however hispidin was not able to display any apoptosis in the pre-treatment with n-acetyl-l-cysteine, a ros scavenger [1].
in vivo
previous animal study found that the treatment with pkc-activating agent phorbol-12-myristate-13-acetate could attenuate exendin-4-induced relaxations and reduced glp-1r expression in wistar-kyoto rat arteries, which were reversed by hispidin [2].
IC 50
2 μm
References
[1] lim jh, lee ym, park sr, kim dh, lim bo. anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. anticancer res. 2014 aug;34(8):4087-93.
[2] liu l, liu j, gao y, ng cf, yu x, dou d, huang y. protein kinase cβ mediates downregulated expression of glucagon-like peptide-1 receptor in hypertensive rat renal arteries. j hypertens. 2015 apr;33(4):784-90; discussion 790.
HISPIDIN Preparation Products And Raw materials
Raw materials
Preparation Products
HISPIDIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Lihe Wuhan New Chemical Materials Co., Ltd. | 027-88395709 | China | 427 | 50 |
