Homocystine
- CAS No.
- 462-10-2
- Chemical Name:
- Homocystine
- Synonyms
- DL-HOMOCYSTINE;HOMOCYSTINE;Homocystine USP/EP/BP;Product NameL-homocystine Synonyms;4,4'-dithiobis[2-aminobutyric] acid;L-4,4'-Dithiobis(2-aminobutyric acid);4,4'-dithiobis[2-amino-Butanoic acid];Butanoic acid, 4,4'-dithiobis[2-amino-;4,4'-Disulfanediylbis(2-aMinobutanoic acid);4,4’-Disulfanediylbis(2-aminobutanoic Acid)
- CBNumber:
- CB3506048
- Molecular Formula:
- C8H16N2O4S2
- Molecular Weight:
- 268.35
- MDL Number:
- MFCD00063095
- MOL File:
- 462-10-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Dl-homocystine | H591305 | 1g | $75 |
| L-Homocystine | 279871 | 1g | $373 |
| HOMOCYSTINE 95.00% | AAA0008872 | 5MG | $496.54 |
| 4,4'-Disulfanediylbis(2-aminobutanoic acid) | FD140233 | 250g | $577.5 |
| HOMOCYSTINE 95.00% | AAA0008872 | 5G | $710 |
| More product size | |||
| Melting point | 281-284°C (dec.) |
|---|---|
| alpha | 77 º (c=1%,1N HCl) |
| Boiling point | 507.6±50.0 °C(Predicted) |
| Density | 1.443±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Aqueous Acid (Slightly). Aqueous Base (Slightly) |
| form | Solid |
| pka | 1.90±0.10(Predicted) |
| color | White to Off-White |
| optical activity | 1.3°(C=0.01g/mL, H2O, 20°C, 589nm) |
| FDA UNII | Q5T8GG4YC6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| HS Code | 2930909899 | |||||||||
| NFPA 704 |
|
Homocystine price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H591305 | Dl-homocystine | 462-10-2 | 1g | $75 | 2021-12-16 | Buy |
| Usbiological | 279871 | L-Homocystine | 462-10-2 | 1g | $373 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0008872 | HOMOCYSTINE 95.00% | 462-10-2 | 5MG | $496.54 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD140233 | 4,4'-Disulfanediylbis(2-aminobutanoic acid) | 462-10-2 | 250g | $577.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0008872 | HOMOCYSTINE 95.00% | 462-10-2 | 5G | $710 | 2021-12-16 | Buy |
Homocystine Chemical Properties,Uses,Production
Uses
DL-Homocystine is used in the synthesis of potential antitumor agents through inhibition of L-asparagine. There is growing clinical evidence that elevated homocysteine levels are associated with an increased risk of venous and arterial thrombosis.
Definition
ChEBI: An organic disulfide obtained by oxidative dimerisation of homocysteine.
Synthesis
59-51-8
462-10-2
The general procedure for the synthesis of 4,4'-dithiobis(2-aminobutyric acid) from DL-methionine was as follows: D,L-methionine (40 g, 0.268 mol) was placed in a 2 L Erlenmeyer flask, which was equipped with a Claisen fitting, a dry ice condenser, a glass-coated magnetic stirrer, and potassium hydroxide tubes at the inlet and outlet. First, the device was vigorously flushed with dry ammonia. After approximately 1 L of ammonia had condensed, the gas delivery tube was removed and sealed with a frosted glass plug. Subsequently, 3.1 equivalents of sodium (18.5 g, 0.8 mol) were added in small portions over a period of 2 h until the dark blue color of the reaction mixture persisted for at least 20 min. A small amount of ammonium chloride was added to quench the excess sodium, causing the solution to fade. Stirring was stopped and the reaction mixture was cooled and the ammonia was allowed to evaporate naturally at room temperature overnight. A white solid with a typical homocysteine odor was dissolved in 400 mL of water and the solution was acidified by slow dropwise addition of 2 M HCl until the pH reached 4-5. The flask was placed in an ice bath and 30% H2O2 (28 mL) was added dropwise with stirring. Precipitation of the product began within a few minutes after addition of all the hydrogen peroxide. Stirring was continued and cooled for 5 hours. Subsequently, crystals were collected using a Brinell funnel, washed with 500mL of water, frozen and lyophilized at 80°C. Yield: 29.6g (82%). The product is a white solid with a melting point of 260-280°C (decomposition, literature value 260-265°C decomposition). Elemental analysis calculated values (C8H16N2O4S2, 268.35): C 35.81%, H 6.01%, N 10.44%; measured values: C 35.84%, H 6.14%, N 10.18%. Thin-layer chromatography Rf = 0.40 (solvent system S5). 1H NMR (600 MHz, D2O + NaOD): δ= 3.33 (m, 2H, 2×N-CH), 3046 s (OH); 1659 (C=O); 1600 vs, 1412 vs (COO-); 2609 m, 1573 s, 1531 m (NH+). High-resolution mass spectrometry (ESI) calculated value C8H17O4N2S2 [M+H]+ 269.06242, measured value: 269.06247.
Purification Methods
dl-Homocystine crystallises in platelets from water with 1H2O and m 258-260o(dec), all operations should be carried out under N2. [Sudo J Chem Soc Jpn (Pure Chem Sect) 79 81, 86, 87 1958, Beilstein 4 IV 3199.]
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 256 - 275
[2] Journal of Biological Chemistry, 1932, vol. 97, p. XXI
[3] Journal of Biological Chemistry, 1954, vol. 207, p. 97
[4] Journal of Biological Chemistry, 1934, vol. 105, p. 482
[5] Journal of Biological Chemistry, 1932, vol. 99, p. 135,140
Homocystine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9546 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 10000 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1262 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
View Lastest Price from Homocystine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | 4,4'-Disulfanediylbis(2-aminobutanoic acid)
462-10-2
|
US $29.00 / g | 99.96% | 10g | TargetMol Chemicals Inc. |
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- 4,4'-Disulfanediylbis(2-aminobutanoic acid)
462-10-2
- US $29.00 / g
- 99.96%
- TargetMol Chemicals Inc.
