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2,4-Piperadinedione

2,4-Piperadinedione structure

CAS No.: 50607-30-2

Chemical Name:: 2,4-Piperadinedione

Synonyms: Piperidine-2,4-dione;PIPERIDIN-2,4-DIONE;2,4-Piperidinedione;2,4-Diketopiperidine;2,4-Dioxopiperidine;2,4-PIPERADINEDIONE;2,4-PiperadinedioneE;2,4-Piperidinedione>Piperidine-2,4-dione 97%;2,4-Piperidinedione, 98%

CBNumber:: CB3511804

Molecular Formula:: C5H7NO2

Molecular Weight:: 113.11

MDL Number:: MFCD08704814

MOL File:: 50607-30-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:45:30

Product description	Number	Pack Size	Price
2,4-Piperidinedione 97%	759368	250mg	$72.3
2,4-Piperidinedione >98.0%(GC)(T)	P2296	200mg	$21
2,4-Piperidinedione >98.0%(GC)(T)	P2296	1g	$51
2,4-Piperidinedione ≥98%(GC)	43519	200MG	$21.93
2,4-Piperidinedione ≥98%(GC)	43519	1G	$81.92
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2,4-Piperadinedione Properties

Melting point	98.0 to 102.0 °C
Boiling point	362.1±35.0 °C(Predicted)
Density	1.184±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to crystal
pka	12.00±0.70(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C5H7NO2/c7-4-1-2-6-5(8)3-4/h1-3H2,(H,6,8)
InChIKey	RDNZDMDLRIQQAX-UHFFFAOYSA-N
SMILES	N1CCC(=O)CC1=O
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H317-H319-H335
Precautionary statements	P280-P301+P312+P330-P302+P352-P305+P351+P338
target organs	Respiratory system
Hazard Codes	Xn
Risk Statements	22-36/37/38-43
Safety Statements	26-36/37
RIDADR	UN 3335
WGK Germany	3
HS Code	2933790090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3

2,4-Piperadinedione price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	759368	2,4-Piperidinedione 97%	50607-30-2	250mg	$72.3	2026-04-30	Buy
TCI Chemical	P2296	2,4-Piperidinedione >98.0%(GC)(T)	50607-30-2	200mg	$21	2026-04-30	Buy
TCI Chemical	P2296	2,4-Piperidinedione >98.0%(GC)(T)	50607-30-2	1g	$51	2026-04-30	Buy
Chem-Impex	43519	2,4-Piperidinedione ≥98%(GC)	50607-30-2	200MG	$21.93	2026-05-19	Buy
Chem-Impex	43519	2,4-Piperidinedione ≥98%(GC)	50607-30-2	1G	$81.92	2026-05-19	Buy

Product number	Packaging	Price	Buy
759368	250mg	$72.3	Buy
P2296	200mg	$21	Buy
P2296	1g	$51	Buy
43519	200MG	$21.93	Buy
43519	1G	$81.92	Buy

2,4-Piperadinedione Chemical Properties,Uses,Production

Description

2,4-Piperidinedione is an important piperidine ring-containing intermediate, and its 2,4-piperidinedione, as a characteristic fragment, is widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs.

Chemical Properties

White to light yellow solid

Uses

2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGFβ/Smad inhibitors.

Preparation

The synthesis of 2,4-Piperidinedione involved dissolving 400 mg (2.34 mmol, 1.00 eq.) of Methyl 2,4-dioxo-piperidine-3-carboxylate in a mixture of acetonitrile (20 mL) and water (0.2 mL). The solution was then heated to approximately 86° C. and maintained at this temperature for around 4 hours. After completion of the reaction, the solvent was removed under vacuum, leaving behind a residue of 2,4-Piperidinedione. This residue was further purified using silica gel column chromatography with a mobile phase consisting of dichloromethane and methanol in a ratio of 100:1. The target product, 2,4-Piperidinedione, was obtained as a white solid, with a yield of 27%, corresponding to 70 mg.

Synthesis

TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

845267-78-9

50607-30-2

The general procedure for the synthesis of 2,4-piperidinediones from tert-butyl 2,4-dipiperidone-1-carboxylate was as follows: at 0 °C and under nitrogen protection, Boc-β-alanine (25 g, 132 mmol), Meldrum acid (20.9 g, 145 mmol), and 4-dimethylaminopyridine (DMAP, 24.2 g, 198 mmol) were dissolved in 700 mL of anhydrous dichloromethane (DCM). To this solution was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI, 30.4 g, 158 mmol). The reaction mixture was slowly warmed to room temperature and stirred overnight. After completion of the reaction, the reaction mixture was washed with 5% KHSO4 aqueous solution (0.5 L x 4). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product [tert-butyl [3-(2,2-dimethyl-4,6-dioxo-[1,3]dioxol-5-yl)-3-oxo-propyl]-carbamate. The crude product was dissolved in 600 mL of ethyl acetate and refluxed for 4 hours. It was concentrated under reduced pressure to a volume of about 150 mL and subsequently crystallized at 4°C overnight. The solid was collected by filtration and washed with cold ethyl acetate to afford 18.4 g (65% yield) of 2,4-piperidinedione.1H NMR (400 MHz, DMSO-D6) δppm: 1.44 (s, 9H), 2.44 (m, 2H), 3.71 (m, 2H), 4.95 (s, 1H), 11.2 (bs, 1H). The resulting product was converted quantitatively to piperidine-2,4-dione by dissolving in dichloromethane and treating with trifluoroacetic acid for 3 h at room temperature.

References

[1] Patent: WO2008/104475, 2008, A1. Location in patent: Page/Page column 22
[2] Patent: WO2012/35078, 2012, A1. Location in patent: Page/Page column 144
[3] Patent: US2014/45872, 2014, A1. Location in patent: Paragraph 0911
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 3, p. 487 - 501
[5] Angewandte Chemie - International Edition, 2014, vol. 53, # 14, p. 3594 - 3598

2,4-Piperadinedione synthesis

Synthesis of 2,4-Piperadinedione from TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE

2,4-Piperadinedione Preparation Products And Raw materials

Raw materials

PICRIC ACID Benzyltrimethylammonium hydroxide Sodium Ethanethiol N-phenylsulfanylbenzenesulfenamide

Ethyl acrylate Ethyl malonyl chloride TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE Trifluoroacetic acid Dichloromethane

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Preparation Products

4-hydroxy-2-Piperidinone 2,4-Piperidinedione,3-[(dimethylamino)methylene]-(9CI)

2,4-Piperadinedione Suppliers

Global( 248)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20122	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	923	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58

Supplier	Advantage
Accela ChemBio Inc.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Nanjing Baifuli Technology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58

View Lastest Price from 2,4-Piperadinedione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-25	Piperidine-2,4-dione 50607-30-2	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2019-07-06	2,4-Piperadinedione 50607-30-2	$1.00	1KG	99%		Career Henan Chemical Co
2019-07-06	2,4-PiperadinedioneE 50607-30-2	$1.00	1KG	97%	200KG	Career Henan Chemical Co

Piperidine-2,4-dione
50607-30-2
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

2,4-Piperadinedione
50607-30-2
$1.00
99%
Career Henan Chemical Co

2,4-PiperadinedioneE
50607-30-2
$1.00
97%
Career Henan Chemical Co

2,4-Piperadinedione Spectrum

2,4-Piperadinedione(50607-30-2)¹HNMR

50607-30-2(2,4-Piperadinedione)Related Search:

DROPERIDOL Haloperidol 2',4'-Dichloroacetophenone Triacetonediamine 2,2,6,6-Tetramethyl-4-piperidinol

METHYPRYLON Diphenoxylate 3,3-DIMETHYLGLUTARIMIDE DL-Glutethimide 2,6-Dioxopiperidine-3-ammonium chloride

Aminoglutethimide Ethyl 4-(4,4-dimethyl-2,6-dioxopiperidin-1-yl)benzoate 1-benzylpiperidine-3,5-dione 5-ETHYL-2,4-PIPERIDINEDIONE Antineoplaston A10

N-Benzyl-2,6-piperidinedion 6-Phenylazaperhydroine-2,4-dione 3-ETHYL-3-METHYLGLUTARIMIDE

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piperidine-2,4-dione, dihydropyridine-4,6-dione, 2,4-dioxopiperidine, 2,4-piperidinedione, piperidin-2,4-dione, 2,4-diketopiperidine, Piperidine-2,4-dione 2,4-PiperadinedioneE Piperidine-2,4-dione 97% 2,4-PIPERADINEDIONE PIPERIDIN-2,4-DIONE dihydropyridine-4,6-dione 2,4-Dioxopiperidine 2,4-Piperidinedione, 95+% 2,4-Piperidinedione> 2,4-Piperidinedione,Piperidine-2,4-dione 2,4-Piperidinedione (9CI, ACI) 2,4-Piperidinedione, 98% Aminoglutethimide Impurity 7 2,4-Piperidinedione 2,4-Diketopiperidine Piperidine-2,4-dione 50607-30-2 Pharmaceutical intermediate Heterocycles series