tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
- CAS No.
- 939681-36-4
- Chemical Name:
- tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
- Synonyms
- G5-7;G5-7, 10 mM in DMSO;JAK2 inhibitor 5-7;tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3,5-bis[(2-fluorophenyl)methylene]-4-oxo-, ethyl ester;antiangiogenic,inhibit,Apoptosis,JAK,Glioma,G-5-7,cycle,G5 7,phase,G57,STAT3,cell,Inhibitor,EGFR,Janus kinase,G5-7,mTOR
- CBNumber:
- CB35438865
- Molecular Formula:
- C22H19F2NO3
- Molecular Weight:
- 383.39
- MDL Number:
- MOL File:
- 939681-36-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0086991 | G5-7 99.84% | 939681-36-4 | 5mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0086991 | G5-7 99.84% | 939681-36-4 | 10mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0086991 | G5-7 99.84% | 939681-36-4 | 25mg | $550 | 2021-12-16 | Buy |
| Ambeed | A253292 | tert-Butyl3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate 98+% | 939681-36-4 | 25mg | $589 | 2021-12-16 | Buy |
| Ambeed | A253292 | tert-Butyl3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate 98+% | 939681-36-4 | 50mg | $882 | 2021-12-16 | Buy |
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Chemical Properties,Uses,Production
Uses
G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study[1].
in vivo
G5-7 (10 and 50 mg/kg, oral gavege) decreases VEGF secretion and exerts a potent antiangiogenic effect[1].
| Animal Model: | Cells (4 × 106) in 100 μl of serum-free DMEM were inoculated subcutaneously into 5- to 6-week-old female nude mice[1]. |
| Dosage: | 10 and 50 mg/kg. |
| Administration: | Oral gavage. |
| Result: | Suppresses angiogenesis in tumors. |
IC 50
JAK2
References
[1] Kunyan He, et al. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55. DOI:10.1126/scisignal.2003900
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6439 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
