Tetraacetylphytosphingosine
- CAS No.
- 13018-48-9
- Chemical Name:
- Tetraacetylphytosphingosine
- Synonyms
- TETRAACETYLPHYTOSPHINGOSINE;Tetraacetylphytosphingosine >Tetraacetyl-D-ribo-Phytosphingosine;Tetraacetylphytosphingosine >=98% (HPLC);Acetamide, N-[(1S,2S,3R)-2,3-bis(acetyloxy)-1-[(acetyloxy)methyl]heptadecyl]-
- CBNumber:
- CB35550091
- Molecular Formula:
- C26H47NO7
- Molecular Weight:
- 485.65
- MDL Number:
- MOL File:
- 13018-48-9.mol
| Product description | Number | Pack Size | Price |
| Tetraacetylphytosphingosine ≥98% (HPLC) | SMB00703 | 5 mg | $123 |
| Tetraacetylphytosphingosine ≥98% (HPLC) | SMB00703 | 25 mg | $496 |
| Melting point | 46 °C |
|---|---|
| Boiling point | 594.3±50.0 °C(Predicted) |
| Density | 1.021±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ethanol: ≤25mg/mL |
| form | solid |
| pka | 14.72±0.46(Predicted) |
| InChIKey | SGTYQWGEVAMVKB-NXCFDTQHSA-N |
| SMILES | C(N[C@@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)CCCCCCCCCCCCCC)(=O)C |
| FDA UNII | S6T795QLF2 |
| UNSPSC Code | 12352211 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS09,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H400-H318-H410 |
| Precautionary statements | P273-P391-P501-P280-P305+P351+P338-P310-P273-P391-P501 |
Tetraacetylphytosphingosine price
Tetraacetylphytosphingosine Chemical Properties,Uses,Production
Description
Tetraacetylphytosphingosine (TAPS) is a sphingolipid metabolite produced by Wickerhamomyces ciferrii (also known as Hansenula ciferrii). It exerts an inhibitory action on angiogenesis through inhibition of the mitogen-activated protein kinase (MAPK) pathway and intracellular calcium increase. Therefore, TAPS was suggested as a potential treatment for angiogenesis related disorders such as arthritis, cancer and psoriasis.
Uses
Tetraacetylphytosphingosine(TAPS) is a modified form of phytoshingosine, which is a component found in the lipid layer of the skin and known for Moisturizing and Repairing the Skin. TAPS functions as a lipid source, contributing to the water-locking barrier of the skin's outer layer, the stratum corneum. This helps to increase the overall ceramide content in the skin, which is crucial for maintaining skin hydration and preventing dehydration by bolstering the skin's barrier function. Improving Dark Circles, TAPS has been found to inhibit the formation and leakage of capillaries. This action can be beneficial in improving the appearance of dark circles under the eyes. Promoting Skin Cell Regeneration and Repair, TAPS is also known to promote the regeneration and repair of skin cells. It stimulates the synthesis of critical structural proteins like collagen and elastic fibers, vital for maintaining skin elasticity and firmness.
Biological Activity
Tetraacetylphytosphingosine was found to induce apoptosis in HaCaT human keratinocyte cells. In addition, it was demonstrated that TAPS synergistically increases UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2 in HaCaT cells.
in vitro
Tetraacetylphytosphingosine (TAPS; 5 μM; 24 h) markedly decreases VEGF-induced chemotactic migration and capillary-like tube formation in HUVEC. It significantly inhibits VEGF-induced proteolytic enzyme production, including MMP-2, urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1). It also suppresses VEGF-induced phosphorylation of p42/44 extracellular signal-regulated kinase and c-JNK. In addition, Tetraacetylphytosphingosine abolished VEGF-induced intracellular calcium increase. In HaCaT cells, Tetraacetylphytosphingosine co-treatment synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating pro-apoptotic Bax and anti-apoptotic Bcl-2 levels.
Tetraacetylphytosphingosine Preparation Products And Raw materials
Raw materials
Preparation Products
Tetraacetylphytosphingosine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 240 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21614 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3979 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9941 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 6085 | 58 |
| Mensura Group Limited | 18780014153 | 1058503172@qq.com | China | 2900 | 58 |
| Chongqing Chuanchong Technology Co., Ltd | 023-67015921 19522053615 | 1142568342@qq.com | China | 20 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 | shenlinxing@macklin.cn | China | 15873 | 55 |
View Lastest Price from Tetraacetylphytosphingosine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-21 | Tetraacetylphytosphingosine
13018-48-9
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 96.8%HPLC | 2000kgs | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2025-10-21 | Tetraacetyl-D-ribo-Phytosphingosine
13018-48-9
|
US $0.00-0.00 / kg | 0.1kg | 92.5% | 2000kgs | Chongqing Zhihe Biopharmaceutical Co., Ltd. |
-
- Tetraacetylphytosphingosine
13018-48-9
- US $0.00-0.00 / kg
- 96.8%HPLC
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- Tetraacetyl-D-ribo-Phytosphingosine
13018-48-9
- US $0.00-0.00 / kg
- 92.5%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
