SPR-741
- CAS No.
- 1179330-52-9
- Chemical Name:
- SPR-741
- Synonyms
- NAB741;SPR-741;SPR741TFA;SPR741 (NAB741);2-10-Polymyxin B1, N-acetyl-3-D-serine-
- CBNumber:
- CB35590033
- Molecular Formula:
- C44H73N13O13
- Molecular Weight:
- 992.15
- MDL Number:
- MFCD33029242
- MOL File:
- 1179330-52-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SPR741 | EXB33052 | 10mg | $853.8 |
| SPR741 | EXB33052 | 25mg | $1392 |
| SPR741 | EXB33052 | 50mg | $2227 |
| SPR741 99.08% | CS-0079940 | 5mg | $162 |
| SPR741 99.08% | CS-0079940 | 10mg | $271 |
SPR-741 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EXB33052 | SPR741 | 1179330-52-9 | 10mg | $853.8 | 2026-06-04 | Buy |
| Biosynth | EXB33052 | SPR741 | 1179330-52-9 | 25mg | $1392 | 2026-06-04 | Buy |
| Biosynth | EXB33052 | SPR741 | 1179330-52-9 | 50mg | $2227 | 2026-06-04 | Buy |
| ChemScene | CS-0079940 | SPR741 99.08% | 1179330-52-9 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0079940 | SPR741 99.08% | 1179330-52-9 | 10mg | $271 | 2026-06-04 | Buy |
SPR-741 Chemical Properties,Uses,Production
Uses
SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].
in vivo
SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741[1].
References
[1] Corbett D, et al. Potentiation of Antibiotic Activity by a Novel Cationic Peptide: Potency and Spectrum of Activity of SPR741. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00200-17. DOI:10.1128/AAC.00200-17
[2] Eckburg PB, et al. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00892-19. DOI:10.1128/AAC.00892-19
SPR-741 Preparation Products And Raw materials
Raw materials
Preparation Products
SPR-741 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15178 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 19372819560 | Sales@ATKchemical.com | China | 9625 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303; | Caroline@youngshechem.com | China | 4793 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7617 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
