MUC1 (VU4H5) Mouse mAb

Source

Mouse

Reactivity

Human

Background

Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation. MUC1 is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail. MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation. MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail. Overexpression of MUC1 potentiates transformation and attenuates stress-induced apoptosis through the Akt or p53 pathways.

References

[1] Baldus, S.E. et al. (2004) Crit Rev Clin Lab Sci 41, 189-231.
[2] Schroeder, J.A. et al. (2001) J Biol Chem 276, 13057-64.
[3] Li, Y. et al. (1998) Mol Cell Biol 18, 7216-24.
[4] Li, Y. et al. (2001) J Biol Chem 276, 6061-4.
[5] Ren, J. et al. (2002) J Biol Chem 277, 17616-22.
[6] Schroeder, J.A. et al. (2004) Oncogene 23, 5739-47.
[7] Raina, D. et al. (2004) J Biol Chem 279, 20607-12.
[8] Wei, X. et al. (2005) Cancer Cell 7, 167-78.

Raw materials

Preparation Products