3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
![3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- Structure](CAS/20200515/GIF/204592-94-9.gif)
- CAS No.
- 204592-94-9
- Chemical Name:
- 3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
- Synonyms
- LY377604;LY-377604,LY377604;3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]-
- CBNumber:
- CB35912145
- Molecular Formula:
- C31H32N4O4
- Molecular Weight:
- 524.61
- MDL Number:
- MFCD30187496
- MOL File:
- 204592-94-9.mol
- MSDS File:
- SDS
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- Properties
| Boiling point | 809.4±65.0 °C(Predicted) |
|---|---|
| Density | 1.282±0.06 g/cm3(Predicted) |
| pka | 13.94±0.20(Predicted) |
| form | Solid |
| color | Off-white to light brown |
| FDA UNII | OCC6TB3P6K |
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- Chemical Properties,Uses,Production
Uses
LY377604 is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.
in vivo
Administration of LY377604 to male Long-Evans rats fed a caloric dense diet results in stimulation of lipid utilization. This is observed as a decrease in respiratory quotient and persists for about 4 h before returning to that measured from vehicle-treated rats[1].
References
[1] Jesudason CD, et al. Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity. ACS Med Chem Lett. 2011 May 23;2(8):583-6. DOI:10.1021/ml200071k
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- Preparation Products And Raw materials
Raw materials
Preparation Products
3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]-2-methylpropyl]phenoxy]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10505 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Foshan Heshuo Pharm technology Co., ltd | 15363639686 | heshuoyiyao@hotmail.com | China | 2373 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
