Rabeprazole

Rabeprazole Properties

Melting point	99-100° (dec)
Boiling point	603.9±65.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.57±0.10(Predicted)
form	Solid
color	Light Brown to Very Dark Brown
BCS Class	1,3
Stability	Hygroscopic
InChI	InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey	YREYEVIYCVEVJK-UHFFFAOYSA-N
SMILES	C1(S(CC2=NC=CC(OCCCOC)=C2C)=O)NC2=CC=CC=C2N=1
CAS DataBase Reference	117976-89-3(CAS DataBase Reference)
FDA UNII	32828355LL
ATC code	A02BC04,A02BC54

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H413
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xi
Risk Statements	36/38
Safety Statements	26-37/39
Hazardous Substances Data	117976-89-3(Hazardous Substances Data)

Rabeprazole price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	R070540	Rabeprazole	117976-89-3	500mg	$875	2021-12-16	Buy
Biosynth Carbosynth	IM57864	Rabeprazole	117976-89-3	10g	$550	2021-12-16	Buy
Medical Isotopes, Inc.	61545	Rabeprazole	117976-89-3	50mg	$610	2021-12-16	Buy
ApexBio Technology	B3467	Rabeprazole	117976-89-3	10mM(in 1mL DMSO)	$90	2021-12-16	Buy
Biosynth Carbosynth	IM57864	Rabeprazole	117976-89-3	2g	$180	2021-12-16	Buy

Product number	Packaging	Price	Buy
R070540	500mg	$875	Buy
IM57864	10g	$550	Buy
61545	50mg	$610	Buy
B3467	10mM(in 1mL DMSO)	$90	Buy
IM57864	2g	$180	Buy

Rabeprazole Chemical Properties,Uses,Production

Description

Rabeprazole, a proton pump inhibitor (PPI), effectively lowers stomach acid production to alleviate conditions such as gastroesophageal reflux disease (GERD), ulcers, and other issues caused by excessive acid production. It belongs to the benzimidazole derivative family, sharing a structural similarity with omeprazole, another PPI. Rabeprazole hampers the activity of the gastric proton pump responsible for acid production. By binding to the pump, it obstructs the release of hydrogen ions into the stomach, ultimately reducing acid production. Furthermore, rabeprazole exhibits various biochemical and physiological effects. A study conducted on rats revealed that rabeprazole effectively decreases the gastric proton pump′s activity, leading to a decrease in gastric acid secretion.

Uses

Rabeprazole is used to treat hyperacidity. It is a proton pump inhibitor that helps heal gastrointestinal ulcers, treats gastroesophageal reflux disease, and also treats hypersecretory disorders.

Definition

ChEBI: Rabeprazole is a member of benzimidazoles, a sulfoxide and a member of pyridines. It has a role as an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor and an anti-ulcer drug. It is a conjugate acid of a rabeprazole(1-).

brand name

Aciphex (Eisai Medical Research) .

Mechanism of action

Rabeprazole is a proton pump inhibitor (PPI) and as such covalently binds with and inactivates the gastric parietal cell proton pump (H+/K+-ATPase). This inhibits in turn gastric acid production and raises gastric pH[1].

Pharmacokinetics

Rabeprazole is marketed as an enterically coated formulation due to the instability of all PPIs in an acid environment. After oral ingestion, it is relatively rapidly absorbed as the maximal plasma concentration reaches between 2.8 and 5.1 postdose. The pharmacokinetics of the molecule is linear in the range 10–80 mg with an overall bioavailability of 52%. Rabeprazole does not have a saturable first-pass metabolism, and it can be absorbed in high doses.
Neither antacids nor food influences the bioavailability of the molecule, even if food intake delayed the absorption of rabeprazole 20 mg of about 1.7 h and reduced the apparent elimination half-life due to a probable delayed gastric emptying. Preclinical studies have demonstrated that rabeprazole’s volume of distribution is 0.34 L/kg in various tissues, including the gastric mucosa, stomach, kidney, bladder, liver, intestine, and thyroid. In healthy volunteers, it was demonstrated to be bound to 94.8%–97.5% of plasma proteins.

Side effects

The more common side effects of rabeprazole can include: headache. pain in the abdomen (stomach area) sore throat.
The serious side effects of rabeprazole can include: has stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea or vomiting, or unusual tiredness or weakness. This medicine may increase your risk of having fractures of the hip, wrist, and spine.

Synthesis

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

117977-21-6

117976-89-3

The general procedure for the synthesis of 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole from 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole was as follows: Example 6: 2.0 g of 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzo[d]imidazole was suspended in 36 mL of methanol at room temperature. Subsequently, 1.93 g of a 14 mL aqueous solution of 45% NaOH was added with stirring. 0.09 g of Na2WO4-2H2O oxidizing catalyst was dissolved in 0.66 g of 50% H2O2 aqueous solution and further diluted with 10 mL of water. The oxidizer/catalyst solution was slowly added dropwise to the reactant/base solution, and the dropwise process was completed in about 30 minutes while maintaining room temperature and continuous stirring. After the dropwise addition was completed, the reaction was continued with stirring for 10 minutes. Then, 10 mL of 10% Na2S2O3 aqueous solution was added and the reaction mixture was concentrated under reduced pressure to remove methanol. Finally, the pH was adjusted to about 8 by adding dilute aqueous acetic acid to form a precipitate. The precipitate was filtered, washed with water, and dried under vacuum to give rabeprazole in about 88% yield (LC purity >95%).

Drug interactions

A product that may interact with this drug is: methotrexate (especially high-dose treatment).
Some products need stomach acid so that the body can absorb them properly. Rabeprazole decreases stomach acid, so it may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

Dosage

Rabeprazole is usually taken once a day. Follow all directions on the prescription label and read all dosing instructions or instruction sheets. Use the medication exactly as directed.Rabeprazole is only suitable for short-term use, usually 4 to 8 weeks. If you need additional treatment time, your doctor may recommend a second course of treatment.

References

[1] Fabio Pace. “A review of rabeprazole in the treatment of acid-related diseases.” Therapeutics and Clinical Risk Management 3 3 (2007): 363–79.

Rabeprazole synthesis

Synthesis of Rabeprazole from 2,3-dimethyl-4-(3-methoxy-propoxy)pyridine and 1H-Benzimidazole-2-sulfinic acid, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester

Rabeprazole Preparation Products And Raw materials

Raw materials

Trifluoroacetic anhydride Ethanol Dichloromethane 4-Nitro-2,3-lutidine-N-oxide Triethylamine

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 2-Mercaptobenzimidazole Rabeprazole Sulfide N-Oxide 2,3-dimethyl-4-(3-methoxy-propoxy)pyridine (2S,3S)(-)-Dihydroxybutane-1,4-dioic acid diethyl ester

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Preparation Products

Rabeprazole Sodium

Rabeprazole Suppliers

Global( 266)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32431	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7958	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15146	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Jurong Coupling Biotechnology Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Xi'an MC Biotech, Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Rabeprazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-18	Rabeprazole 117976-89-3	US $31.00-77.00 / mg		97.06%	10g	TargetMol Chemicals Inc.
2025-09-18	Rabeprazole 117976-89-3	US $0.00-0.00 / Kg/Drum	1KG	98%min	500kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-07-11	Rabeprazole 117976-89-3	US $0.00-0.00 / G/Bag	1G/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.

Rabeprazole
117976-89-3
US $31.00-77.00 / mg
97.06%
TargetMol Chemicals Inc.

Rabeprazole
117976-89-3
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Rabeprazole
117976-89-3
US $0.00-0.00 / G/Bag
99% up, High Density
Sinoway Industrial co., ltd.

Rabeprazole Spectrum

Rabeprazole(117976-89-3)MS

117976-89-3(Rabeprazole)Related Search:

Methyl salicylate Anisole 4-Methoxybenzoic acid 4-Methoxybenzylchloride (Trifluoromethoxy)benzene

RABEPRAZOLE SODIUM,RABEPRAZOLE, SODIUM SALT,SODIUM RABEPRAZOLE Tribenuron methyl Pirimiphos-methyl Methyl acetate 4-Methoxyphenol

p-Anisidine METSULFURON METHYL 3-(METHOXYMETHOXY)BENZALDEHYDE Kresoxim-methyl 4'-Methoxyacetophenone

p-Anisaldehyde Thiophanate-methyl Pantoprazole

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2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]-1h-benzoimidazole 2-[[(3-METHYL-4-(3-METHOXYPROPOXY)-2-PYRIDINYL)METHYL]SULPHINYL]-1H-BENZIMIDAZOLE 2-(CHOLROMETHYL)-4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE ly-307640 1H-Benzimidazole,2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]- 1H-1,3-benzimidazol-2-yl [4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl sulfoxide-sodium salt 2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole 2-[[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl]sulfinyl]-1H-benzimidazole 2-[3-Methyl-4-(3-methoxypropoxy)-2-pyridinylmethylsulfinyl]-1H-benzimidazole Rebeprazole 2-[(S)-{[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methane}sulfinyl]-1H-1,3-benzodiazole 2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole Rabeprazole Sodium (200 mg) (Sodium 2-[(R)-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl]sulfinyl]benzimidazol-1-ide hydrate) RABEPRAZOLE CS-1363 Rabeprazole, LY 307640 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methane}sulfinyl)-1H-1,3-benzodiazole Rabeprazole USP/EP/BP 2-[[(4-(3-Methoxypropoxy)- 3-methyl-2-pyridinyl)-2- methyl]sulfinyl] -1H-benzimidazole Rabeprazole-IP/USP/IHS NSC 24156 NSC24156 NSC-24156 RABEPRAZOLE 6.25%, 6.89%, 8.5%, 13.33%, 15%, 22.5% PELLETS Diclofop Impurity 10 (Diclocymet) 117976-89-3 117986-89-3 C18H21N3O3S Rabeprazole API's Active Pharmaceutical Ingredients APIs