Pyraclofos
- CAS No.
- 77458-01-6
- Chemical Name:
- Pyraclofos
- Synonyms
- TIA 230;SC 1069;OMS3034;VOLTAGE;BOLTAGE;VOLTAGE(R);BOLTAGE(R);STARLEX(R);PYRACLOFOS;Pyraclofos Standard
- CBNumber:
- CB3681581
- Molecular Formula:
- C14H18ClN2O3PS
- Molecular Weight:
- 360.8
- MDL Number:
- MFCD00274600
- MOL File:
- 77458-01-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| OXO-[1-(4-CHLOROPHENYL)-1H-PYRAZOL-4-YL] OXO-ETHYL S-PROPYL PHOSPHOROTHIOATE 98.00% | HCH0142242 | 0.25G | $935 |
| O-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]O-ethylS-propylphosphorothioate 98% | MT-57377 | 0.25g | $280 |
| More product size | |||
| Melting point | 25°C |
|---|---|
| Boiling point | 164approximate 164℃(0.013hPa) |
| Density | 1.27 |
| vapor pressure | 1.6×10-6 Pa (20 °C) |
| storage temp. | 0-6°C |
| Water Solubility | 33 |
| form | liquid |
| Specific Gravity | 1.271 (28℃) |
| Henry's Law Constant | 2.3×104 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| CAS DataBase Reference | 77458-01-6(CAS DataBase Reference) |
| FDA UNII | M0W5LEC929 |
| EPA Substance Registry System | Phosphorothioic acid, O-[1-(4-chlorophenyl)-1H-pyrazol- 4-yl] O-ethyl S-propyl ester(77458-01-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| RIDADR | 3018 |
| RTECS | TE8346000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29331990 |
Pyraclofos price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0142242 | OXO-[1-(4-CHLOROPHENYL)-1H-PYRAZOL-4-YL] OXO-ETHYL S-PROPYL PHOSPHOROTHIOATE 98.00% | 77458-01-6 | 0.25G | $935 | 2021-12-16 | Buy |
| AHH | MT-57377 | O-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]O-ethylS-propylphosphorothioate 98% | 77458-01-6 | 0.25g | $280 | 2021-12-16 | Buy |
Pyraclofos Chemical Properties,Uses,Production
Uses
Pyraclofos is used to control Lepidoptera, Coleoptera, mites and nematodes in fruit, vegetables, ornamentals and forestry. It has also been used in a human health application to control filarial worms.
Definition
ChEBI: Pyraclofos is an organic thiophosphate, an organothiophosphate insecticide, an organochlorine insecticide, a member of pyrazoles, a member of monochlorobenzenes and an organosulfur compound. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical.
Synthesis
3-Chloropropanone hydrazone undergoes a cyclization reaction in methanol in the presence of sodium hydroxide to prepare 1-(4-chlorophenyl)-4-hydroxypyrazole; 1-(4-chlorophenyl)-4-hydroxypyrazole is reacted in acetonitrile solution in the presence of triethylamine at 50°C for 3 hours, and then reacted with O-ethyl-S-propyl thiophosphate chloride to prepare Pyraclofos.
Metabolic pathway
Pyraclofos is apparently subjected in insects to a metabolic activation to yield a more active acetylcholinesterase inhibitor which is possibly a thiooxidized metabolite. The compound is very rapidly degraded in mammals to inactive metabolites via P-O-aryl, P-O-alkyl and P-S-alkyl cleavage which explains its favourable selective toxicity. In both mammals and plants the principal degradative route is via P-O-aryl cleavage to give 1-(4-chlorophenyl)-4-hydroxypyrazolwe hich is rapidly conjugated.
Metabolism
Pyraclofos is metabolized to an active AChE inhibitor, probably by the oxidation of the sulfur atom in the phosphorothiolate linkage. The half-life in soil is 3–38 d, depending on soil type.
Degradation
The DT50 for hydrolysis in water at pH 7 (25 °C) was 29 days (PM).
Toxicity evaluation
The acute oral LD50 for rats is 237 mg/kg. The inhalation LC50 for rats is 1.69 mg/L air. NOEL (2 yr) for rats is 0.10–0.12 mg/kg diet (0.005–0.006 mg/kg/d). Pyraclofos administered to rats is rapidly degraded, and more than 90% of the dose is excreted principally in the urine within 24 h. The degradation routes are cleavages of the PS, PO-alkyl, and PO-aryl bonds in both animals and plants.
Pyraclofos Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1995 | 65 |
View Lastest Price from Pyraclofos manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | Pyraclofos
77458-01-6
|
US $2.00 / KG | 1KG | 99 | 100kg | Career Henan Chemical Co |
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- Pyraclofos
77458-01-6
- US $2.00 / KG
- 99
- Career Henan Chemical Co
