6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
- CAS No.
- 2240-25-7
- Chemical Name:
- 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
- Synonyms
- 4-Amino-5-bromopyrimidin-2(1H)-one;5-BROMOCYTOSINE;5-Bromocytosine,99%;TIMTEC-BB SBB000280;5-BROMOCYTOSINE 99%;5-Bromocytosine ,97%;5-BROMOCYTOSINE CRYSTALLINE;4-amino-5-bromo-pyrimidin-2-ol;5-Bromocytosine, 10 mM in DMSO;4-amino-5-bromo-2(1h)-pyrimidinon
- CBNumber:
- CB3705357
- Molecular Formula:
- C4H4BrN3O
- Molecular Weight:
- 190
- MDL Number:
- MFCD00056025
- MOL File:
- 2240-25-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Bromocytosine 99% | 150649 | 1g | $194 |
| 5-Bromocytosine | B3170 | 1G | $76 |
| 4-Amino-5-bromopyrimidin-2(1H)-one >98% | A68827 | 5g | $20 |
| 4-Amino-5-bromopyrimidin-2(1H)-one >98% | A68827 | 10g | $30 |
| 4-Amino-5-bromopyrimidin-2(1H)-one >98% | A68827 | 25g | $60 |
| More product size | |||
| Melting point | 240-243 °C (dec.) (lit.) |
|---|---|
| Density | 1.7513 (rough estimate) |
| refractive index | 1.6520 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in formic acid (50 mg/ml). |
| form | Solid |
| pka | 7.34±0.10(Predicted) |
| color | White to yellow |
| BRN | 127286 |
| InChI | InChI=1S/C4H4BrN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9) |
| InChIKey | QFVKLKDEXOWFSL-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(N)=C(Br)C=N1 |
| FDA UNII | 2737MSZ714 |
| NIST Chemistry Reference | 5-Bromocytosine(2240-25-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H317-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41-43-48-20/21/22 | |||||||||
| Safety Statements | 24/25-22-36/37/39-26-45-7/8 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 150649 | 5-Bromocytosine 99% | 2240-25-7 | 1g | $194 | 2023-06-20 | Buy |
| TCI Chemical | B3170 | 5-Bromocytosine | 2240-25-7 | 1G | $76 | 2026-04-30 | Buy |
| Synthonix | A68827 | 4-Amino-5-bromopyrimidin-2(1H)-one >98% | 2240-25-7 | 5g | $20 | 2026-05-06 | Buy |
| Synthonix | A68827 | 4-Amino-5-bromopyrimidin-2(1H)-one >98% | 2240-25-7 | 10g | $30 | 2026-05-06 | Buy |
| Synthonix | A68827 | 4-Amino-5-bromopyrimidin-2(1H)-one >98% | 2240-25-7 | 25g | $60 | 2026-05-06 | Buy |
6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Chemical Properties,Uses,Production
Chemical Properties
LIGHT YELLOW AMORPHOUS POWDER
Uses
4-Amino-5-bromo-2-hydroxypyrimidine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions.
Uses
5-Bromocytosine was used in the synthesis of five cross-link products- C[5-N6]A, C[5-2]A, C[5-8]A, A[2-5]C, and A[8-5]C, under both aerobic and anaerobic conditions.
General Description
5-Bromocytosine derivative (β isomer) is a potent anti-HIV agent.
Synthesis
71-30-7
2240-25-7
General procedure for the synthesis of 4-amino-5-bromopyrimidin-2(1H)-one from 6-aminopyrimidin-2(1H)-one: 6-aminopyrimidin-2(1H)-one (55.6 g, 0.5 mol), N-bromosuccinimide (106.8 g, 0.6 mol) and DMF (150 mL) were added to a reaction flask, cooled to 15°C, and ultrasonicated for reaction under ultrasonic condition for 1 hour. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete reaction of the raw materials, it was filtered. The filter cake was washed with distilled water (20 mL×2) and dried to obtain 4-amino-5-bromopyrimidin-2(1H)-one (90.9 g, 95.6% yield).
Purification Methods
5-Bromocytosine is recrystallised from H2O or 50% aqueous EtOH. Alternatively, dissolve ca 3g in conc HCl (10mL) and evaporate to dryness. Dissolve the residual hydrochloride in the minimum volume of warm H2O and make faintly alkaline with aqueous NH3. Collect the crystals and dry them in a vacuum at 100o. [Hilbdert & Jensen J Am Chem Soc 56 134 1934, Beilstein 25 III/IV 3689.]
References
[1] Patent: CN103819412, 2016, B. Location in patent: Paragraph 0023-0025; 0031-0032; 0037; 0038
[2] Synthesis, 2005, # 7, p. 1103 - 1108
[3] Tetrahedron Letters, 1992, vol. 33, # 50, p. 7779 - 7782
[4] Chemistry Letters, 1987, p. 2311 - 2312
[5] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 11, p. 3750 - 3751
6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 19827 | 58 |
View Lastest Price from 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 5-Bromocytosine
2240-25-7
|
99.94% | 10g | TargetMol Chemicals Inc. | |||
 |
2026-03-30 | 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
2240-25-7
|
1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2025-11-18 | 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
2240-25-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 5-Bromocytosine
2240-25-7
- $0.00
- 99.94%
- TargetMol Chemicals Inc.
-
- 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
2240-25-7
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE
2240-25-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
