2-(Trifluoromethyl)benzoic acid
- CAS No.
- 433-97-6
- Chemical Name:
- 2-(Trifluoromethyl)benzoic acid
- Synonyms
- 2-Carboxybenzotrifluoride;2-(Trifluoromethyl)benzoic;SODIUM HEXAFLUOROANTIMONATE(V);Compound Fr12654;Flutolanil Impurity 1;ANTIMONY SODIUM FLUORIDE;SODIUM ANTIMONY FLUORIDE;2-TRIFLUROMETHYLBENZOIC ACID;α,α,α-trifluoro-o-toluic acid;à,à,à-trifluoro-o-toluic acid
- CBNumber:
- CB3709678
- Molecular Formula:
- C8H5F3O2
- Molecular Weight:
- 190.12
- MDL Number:
- MFCD00002476
- MOL File:
- 433-97-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-(Trifluoromethyl)benzoic acid 98% | 196886 | 5g | $37.4 |
| 2-(Trifluoromethyl)benzoic Acid >98.0%(HPLC)(T) | T1302 | 10g | $41 |
| 2-(Trifluoromethyl)benzoic acid Asreported | 290872 | 25g | $305 |
| 2-(Trifluoromethyl)benzoic acid Asreported | 290872 | 50g | $403 |
| 2-(Trifluoromethyl)benzoic acid Asreported | 290872 | 100g | $531 |
| More product size | |||
| Melting point | 107-110 °C(lit.) |
|---|---|
| Boiling point | 247 °C753 mm Hg(lit.) |
| Density | 3.375 g/mL at 25 °C(lit.) |
| Flash point | 247-254°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.20±0.36(Predicted) |
| form | Crystalline Powder |
| color | Slightly yellow to yellow-brown |
| Water Solubility | 4.8g/L(25 ºC) |
| BRN | 976984 |
| InChI | 1S/C8H5F3O2/c9-8(10,11)6-4-2-1-3-5(6)7(12)13/h1-4H,(H,12,13) |
| InChIKey | FBRJYBGLCHWYOE-UHFFFAOYSA-N |
| SMILES | OC(=O)c1ccccc1C(F)(F)F |
| CAS DataBase Reference | 433-97-6(CAS DataBase Reference) |
| FDA UNII | 0R1CK7MZUA |
| NIST Chemistry Reference | «alpha»,«alpha»,«alpha»-Trifluoro-o-toluic acid(433-97-6) |
| EPA Substance Registry System | Benzoic acid, 2-(trifluoromethyl)- (433-97-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,N,Xi | |||||||||
| Risk Statements | 20/22-51/53-36/37/38 | |||||||||
| Safety Statements | 61-36-26 | |||||||||
| RIDADR | UN 1549 6.1/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 1-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-(Trifluoromethyl)benzoic acid price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 196886 | 2-(Trifluoromethyl)benzoic acid 98% | 433-97-6 | 5g | $37.4 | 2025-07-31 | Buy |
| TCI Chemical | T1302 | 2-(Trifluoromethyl)benzoic Acid >98.0%(HPLC)(T) | 433-97-6 | 10g | $41 | 2026-04-30 | Buy |
| Usbiological | 290872 | 2-(Trifluoromethyl)benzoic acid Asreported | 433-97-6 | 25g | $305 | 2026-06-03 | Buy |
| Usbiological | 290872 | 2-(Trifluoromethyl)benzoic acid Asreported | 433-97-6 | 50g | $403 | 2026-06-03 | Buy |
| Usbiological | 290872 | 2-(Trifluoromethyl)benzoic acid Asreported | 433-97-6 | 100g | $531 | 2026-06-03 | Buy |
2-(Trifluoromethyl)benzoic acid Chemical Properties,Uses,Production
Uses
2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.
Chemical Properties
slightly yellow to yellow-brown crystalline powder
Uses
2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.
Uses
2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy.
Definition
ChEBI: A benzoic acid carrying a trifluoromethyl substituent at the 2-position.
Synthesis
In a 5L stainless steel high-pressure reactor equipped with a mixer and a thermometer, the temperature was lowered to below 5C, hydrogen fluoride and 2-trichloromethyl dichlorobenzyl were added sequentially and the mass ratio of the two was 0.2:1, and then the catalyst perfluorooctane sulfonyl fluoride was added, and the mass ratio of 2-trichloromethyl dichlorobenzyl to the catalyst was 1:0.001, and the reaction pressure was controlled to be 2.5-2.8MPa for 4 hours. The temperature was raised to 80-90C, and the reaction pressure was controlled at 2.5-2.8 MPa for 4 hours. Sampling, GC detection, the intermediate product 2-difluoromonochloromethyl dichlorobenzyl content of 0.3%. At the end of the reaction, the excess hydrogen fluoride was removed by nitrogen purging, and neutralized with aqueous potassium carbonate to pH=6-7. After standing, the product 2-trifluoromethyl dichlorobenzyl chloride was isolated with 96.6% content and 94.1% yield.
The fluorination reaction product 2-trifluoromethyl dichlorobenzyl and nitric acid were reacted to obtain the target compound 2-trifluoromethyl benzoic acid after acid hydrolysis and oxidation reaction.
2-(Trifluoromethyl)benzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3587 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5228 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
View Lastest Price from 2-(Trifluoromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-05 | 2-(Trifluoromethyl)benzoic acid
433-97-6
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-06-05 | 2-(Trifluoromethyl) benzoic acid
433-97-6
|
$60.00 | 1KG | 99% | 300MT/year | Speranza Chemical Co., Ltd. | |
 |
2026-05-28 | 2-(Trifluoromethyl)benzoic acid
433-97-6
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-(Trifluoromethyl)benzoic acid
433-97-6
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-(Trifluoromethyl) benzoic acid
433-97-6
- $60.00
- 99%
- Speranza Chemical Co., Ltd.
-
- 2-(Trifluoromethyl)benzoic acid
433-97-6
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
