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Tetraethylene glycol di-p-tosylate

Tetraethylene glycol di-p-tosylate structure

CAS No.: 37860-51-8

Chemical Name:: Tetraethylene glycol di-p-tosylate

Synonyms: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate);TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE);Tos-PEG5-Tos;Bis-Tos-PEG4;TSO-PEG4-OTS;CAS_37860-51-8;PROTAC Linker 16;TosO-(CH2CH2O)4-Tos;TETRAETHYLENE GLYCOL DITOSYLATE;TETRAETHYLENE GLYCOL DI-P-TOSYLATE

CBNumber:: CB3727438

Molecular Formula:: C22H30O9S2

Molecular Weight:: 502.6

MDL Number:: MFCD00075239

MOL File:: 37860-51-8.mol

MSDS File:: SDS

Last updated:2025-09-17 10:44:43

Product description	Number	Pack Size	Price
Tetraethylene glycol di(p-toluenesulfonate) 97%	341703	10g	$115
Tetraethylene glycol di(p-toluenesulfonate) 97%	341703	50g	$354.2
Tetraethylene Glycol Bis(p-toluenesulfonate) >98.0%(T)	T1493	25g	$148
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 97+%	AS41984	25g	$135
Tetraethylene Glycol Bis(p-toluenesulfonate)	Y4943	1g	$27
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Tetraethylene glycol di-p-tosylate Properties

Melting point	65-69 °C
Boiling point	635.0±55.0 °C(Predicted)
Density	1.242 g/mL at 25 °C (lit.)
refractive index	n20/D 1.53(lit.)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	colorless to yellow
BRN	1610992
InChI	InChI=1S/C22H30O9S2/c1-19-3-7-21(8-4-19)32(23,24)30-17-15-28-13-11-27-12-14-29-16-18-31-33(25,26)22-9-5-20(2)6-10-22/h3-10H,11-18H2,1-2H3
InChIKey	SLAONPBUWDUSSO-UHFFFAOYSA-N
SMILES	O(CCOCCOS(C1=CC=C(C)C=C1)(=O)=O)CCOCCOS(C1=CC=C(C)C=C1)(=O)=O
EPA Substance Registry System	Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, bis(4-methylbenzenesulfonate) (37860-51-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

2909498090

NFPA 704

	1
2		0

Tetraethylene glycol di-p-tosylate price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	341703	Tetraethylene glycol di(p-toluenesulfonate) 97%	37860-51-8	10g	$115	2025-07-31	Buy
Sigma-Aldrich	341703	Tetraethylene glycol di(p-toluenesulfonate) 97%	37860-51-8	50g	$354.2	2025-07-31	Buy
TCI Chemical	T1493	Tetraethylene Glycol Bis(p-toluenesulfonate) >98.0%(T)	37860-51-8	25g	$148	2025-07-31	Buy
Activate Scientific	AS41984	((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) 97+%	37860-51-8	25g	$135	2021-12-16	Buy
AK Scientific	Y4943	Tetraethylene Glycol Bis(p-toluenesulfonate)	37860-51-8	1g	$27	2021-12-16	Buy

Product number	Packaging	Price	Buy
341703	10g	$115	Buy
341703	50g	$354.2	Buy
T1493	25g	$148	Buy
AS41984	25g	$135	Buy
Y4943	1g	$27	Buy

Tetraethylene glycol di-p-tosylate Chemical Properties,Uses,Production

Description

Tos-PEG5-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Uses

Tetraethylene glycol di(p-toluenesulfonate), also known as Tetraethylene glycol di-p-tosylate, was used in the preparation of donor-spacer-acceptor podand system, dual channel fluorosensor for Li⁺, Mg²⁺ and Ca²⁺.

Synthesis

112-60-7

98-59-9

37860-51-8

77544-60-6

20.0 g of tetraethylene glycol triacetonitrile and 10.2 g of triethylamine were added to a reaction flask, 300 mL of acetonitrile was added to dissolve the mixture, and the mixture was cooled to 0-5°C in an ice bath. 19.0 g of p-toluenesulfonyl chloride was dissolved in 100 mL of acetonitrile and slowly added dropwise to the reaction mixture, the dropwise addition time was controlled at 1 hour. After the dropwise addition was completed, the temperature of the reaction mixture was raised to 20-25 °C and the reaction was continued for 12 hours. After completion of the reaction, the solvent was removed by rotary evaporation. The crude product was separated by column chromatography using gradient elution with hexane:ethyl acetate (v/v=4:1) and hexane:ethyl acetate (v/v=1.5:1). In the eluate of hexane:ethyl acetate (v/v=4:1), 12.9 g of oily product (tetraethylene glycol di-p-toluenesulfonate) was obtained in 35.9% yield. In the eluate of hexane:ethyl acetate (v/v=1.5:1), 5.4 g of oily product (tetraethyleneglycol mono-p-toluenesulfonate) was obtained in 10.4% yield.

IC 50

PEGs

storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year;

References

[1] Organic Letters, 2002, vol. 4, # 14, p. 2329 - 2332
[2] Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 11, p. 2094 - 2100
[3] Zhurnal Organicheskoi Khimii, 1990, vol. 26, # 11, p. 2425 - 2433
[4] Patent: CN105541736, 2016, A. Location in patent: Paragraph 0044; 0052
[5] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584

Tetraethylene glycol di-p-tosylate Preparation Products And Raw materials

Raw materials

Bis[2-(2-hydroxyethoxy)ethyl] ether Tosyl chloride Acetonitrile Triethylamine

Preparation Products

S-Acetyl-PEG3-Azido 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Benzo-15-crown-5

Tetraethylene glycol di-p-tosylate Suppliers

Global( 174)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou BEC Biological Technology Co., Ltd.	+undefined13771885869	all@bek.com.cn	China	62	58
Suzhou Highfine Biotech Co.,Ltd.	+86-0512-68071238 +86-13771819922	june@highfine.com	China	458	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13456	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32434	58
Wuhan Borenpharm Co., Ltd	027-65563561 18717150066	3207347307@qq.com	CHINA	1238	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
XIAMEN SINOPEG BIOTECH CO., LTD.	+86-0592-7761068 +8617350879715	changaiwei@sinopeg.com	China	411	58

Supplier	Advantage
Suzhou BEC Biological Technology Co., Ltd.	58
Suzhou Highfine Biotech Co.,Ltd.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Wuhan Borenpharm Co., Ltd	58
Career Henan Chemica Co	58
XIAMEN SINOPEG BIOTECH CO., LTD.	58

View Lastest Price from Tetraethylene glycol di-p-tosylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-17	Bis-Tos-PEG4 37860-51-8	US $29.00 / g		99.06%	10g	TargetMol Chemicals Inc.
2025-09-10	1,11-Bis(tosyloxy)-3,6,9-trioxaundecane 37860-51-8	US $0.00-0.00 / g	1g	98%	1g/bottle, 10g/bottle, 100g/bottle	XIAMEN SINOPEG BIOTECH CO., LTD.
2025-06-07	Tos-PEG5-Tos 37860-51-8	US $0.00 / g	500g	>98.00%	500g	Xian confluore Biological Technology Co., Ltd.

Bis-Tos-PEG4
37860-51-8
US $29.00 / g
99.06%
TargetMol Chemicals Inc.

1,11-Bis(tosyloxy)-3,6,9-trioxaundecane
37860-51-8
US $0.00-0.00 / g
98%
XIAMEN SINOPEG BIOTECH CO., LTD.

Tos-PEG5-Tos
37860-51-8
US $0.00 / g
>98.00%
Xian confluore Biological Technology Co., Ltd.

Tetraethylene glycol di-p-tosylate Spectrum

TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)¹HNMR TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)IR TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)FT-IR TETRAETHYLENE GLYCOL DI-P-TOSYLATE(37860-51-8)Raman

37860-51-8(Tetraethylene glycol di-p-tosylate)Related Search:

Tetraethylene glycol p-toluenesulfonate m-PEG5-Tos TETRAETHYL METHYLENEDIPHOSPHONATE Tetraethylene glycol dimethacrylate TETRAETHYLENEGLYCOL MONOMETHYL ETHER

Tetraethyleneglycol monooctyl ether Tos-PEG13-Tos Tos-PEG10-CH2CH2COOtBu Tos-PEG21-Tos Tos-PEG6-t-Butyl ester

Tos-PEG3-CH2CO2tBu Tos-PEG13-t-butyl ester Tos-PEG5-CH2CO2t-butyl ester Tos-PEG9-t-butyl ester Tos-PEG7-t-butyl ester

Tos-PEG4-t-butyl ester (2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid tert-butyl ester Tos-PEG7-CH2CO2t-butyl ester

1of4

BIS[2-(2-TOSYLOXYETHOXY)ETHYL] ETHER BIS[2-[2-(P-TOLUENESULFONYLOXY)ETHOXY]ETHYL] ETHER TETRAETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) TETRAETHYLENE GLYCOL DI-P-TOSYLATE TETRAETHYLENE GLYCOL DITOSYLATE Tetraethylene glycol di(p-toluenesulfonate) DRAFT CHECKER, AIRFLOW DETECTION POWDER 1,11-Bis(tosyloxy)-3,6,9-trioxaundecane 2,2'-[Oxybis(ethyleneoxy)]diethanol bis(p-toluenesulfonate) Bis(4-methylbenzenesulfonic acid)[oxybis(ethyleneoxyethylene)] ester Bis(4-methylbenzenesulfonic acid)3,6,9-trioxa-1,11-undecanediyl ester Bis(p-toluenesulfonic acid)oxybisethylenebisoxybisethylene ester 2,2'-(Ethylenedioxy)triethyl ditosylate Bis[2-[2-(p-toluenesulfonyloxy)ethoxy]ethyl] Ether Bis[2-(2-tosyloxyethoxy)ethyl] Ether Tetraethylene Glycol Di-p-tosylate 2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate) ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-Methylbenzenesulfonate) Tos-PEG5-Tos ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane... Tetraethylene Glycol Bis(p-toluenesulfonate) PROTAC Linker 16 CAS_37860-51-8 Bis-Tos-PEG4 Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate) Tetraethyleneglycol-di-p-toluenesulphonate 2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate TosO-(CH2CH2O)4-Tos etraethylene glycol di(p-toluenesulfonate) Tos-PEG4-Tos/Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-bis(4-methylbenzenesulfonate) ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfonate) , Bis-Tos-PEG4 Tetraethylene glycol di(p-toluenesulfonate) ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(4-methylbenzenesulfote) TSO-PEG4-OTS 37860-51-8 C22H30O9S C22H30O9S2 CH3C6H4SO3CH2CH2OCH2CH22O Organic Building Blocks Sulfur Compounds Tosylates Building Blocks