Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pyrroloquinoline quinone disodium salt

Pyrroloquinoline quinone disodium salt

Pyrroloquinoline quinone disodium salt Structure
Pyrroloquinoline quinone disodium salt structure
CAS No.
122628-50-6
Chemical Name:
Pyrroloquinoline quinone disodium salt
Synonyms
PQQ;PQQ Disodium Salt;MedChemExpress;pyrroloquinoline quineone;METHOXATIN DISODIUM SALT;PQQ-2Na;PQQ disodium;disodium pyrroloquinolinedione tricarboxylate;PYRROLOQUINOLINE QUINONE DISODIUM SALTPYRROLOQUINOLINE QUINONE DISODIUM SALT;disodium4,5-dihydro-4,5-dioxo-1h-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylat
CBNumber:
CB3728738
Molecular Formula:
C14H4N2Na2O8
Molecular Weight:
374.17
MDL Number:
MFCD00151711
MOL File:
122628-50-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-07 16:58:08
Product description Number Pack Size Price
Methoxatin disodium salt ≥97.0% (HPLC) 80198 10mg $314
Methoxatin disodium salt ≥97.0% (HPLC) 80198 50mg $1290
Methoxatin disodium salt FM31447 0.5g $279.7
Methoxatin disodium salt FM31447 1g $466.2
Methoxatin disodium salt FM31447 2g $745.58
More product size
Request For Quotation

Pyrroloquinoline quinone disodium salt Properties

storage temp. 2-8°C
form Solid
color Pink to red
biological source fermentation/recombinant
Water Solubility Water : 6.16 mg/mL (16.46 mM)
Cosmetics Ingredients Functions ANTIOXIDANT
InChI InChI=1S/C14H6N2O8.Na.H/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;
InChIKey UFVBOGYDCJNLPM-UHFFFAOYSA-L
SMILES C(C1C=C(C(=O)O)N=C2C(=O)C(=O)C3C=C(C(=O)O)NC=3C=12)(=O)O.[NaH]
FDA UNII 8WX58ADB2E
UNSPSC Code 12352005
NACRES NA.79

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
RTECS  UY9454762
F  10-21
Storage Class 11 - Combustible Solids

Pyrroloquinoline quinone disodium salt price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 80198 Methoxatin disodium salt ≥97.0% (HPLC) 122628-50-6 10mg $314 2026-04-30 Buy
Sigma-Aldrich 80198 Methoxatin disodium salt ≥97.0% (HPLC) 122628-50-6 50mg $1290 2026-04-30 Buy
Biosynth FM31447 Methoxatin disodium salt 122628-50-6 0.5g $279.7 2026-06-04 Buy
Biosynth FM31447 Methoxatin disodium salt 122628-50-6 1g $466.2 2026-06-04 Buy
Biosynth FM31447 Methoxatin disodium salt 122628-50-6 2g $745.58 2026-06-04 Buy
Product number Packaging Price Buy
80198 10mg $314 Buy
80198 50mg $1290 Buy
FM31447 0.5g $279.7 Buy
FM31447 1g $466.2 Buy
FM31447 2g $745.58 Buy

Pyrroloquinoline quinone disodium salt Chemical Properties,Uses,Production

Description

Pyrroloquinoline quinone disodium salt (PQQ-NA2) is a water-soluble quinone compound that has a strong antioxidant capacity. This product is a reddish-brown colored powder. It is isolated from cultures of methylotrophic bacteria and tissues of mammals. This essential nutrient is vital for mammals, playing a crucial role in enhancing immune function.
Pyrroloquinoline quinone disodium salt

Uses

Pyrroloquinoline quinone disodium salt (PQQ), as a prototypical oxidoreductase auxiliary group, exhibits superior aqueous solubility and biocompatibility. Beyond its application as a novel food ingredient, PQQ holds promise for use in battery technology. Research has reported an efficient phenanthrazine-expanding strategy based on a diamine-dicarbonyl cyclisation reaction, extending the aromatic fusion ring system of PQQ to yield two water-soluble, redox-active n-heterocyclic compounds: PQQPS and PQQPC. Following the expansion of the π-conjugated structure, their redox potentials exhibited favourable negative shifts exceeding 330 mV. This significantly enhanced the specific capacity (22.63 Ah L−1) and power output (0.205 W cm−2) of aqueous organic redox flow batteries (aORFB), with a capacity retention rate of 97.5% after over 800 cycles (i.e., 99.996% cycle−1 or 99.85% day−1).
[1] GUOCHUN DING. π-Conjugation extended phenazinization of natural prosthetic group pyrroloquinoline quinone disodium salt for long-lifespan biomimetic aqueous redox flow batteries[J]. Nano Energy, 2025, 144: Article 111404. DOI:10.1016/j.nanoen.2025.111404.

Uses

Pyrroloquinoline quinone disodium salt (PQQ-NA2) can act as an antioxidant and there is strong evidence that PQQ may play an important role in important pathways of cell signaling. PQQ plays a variety of physiological roles, such as promoting growth and reproduction and providing neurological and cardiovascular protection.

Application

Pyrroloquinoline quinone disodium salt (PQQ-NA2) protects cells from oxidative damage and increases the mitochondrial membrane potential, which is essential for the production of ATP. It also stimulates enzyme activities, such as glutathione peroxidase and glutathione reductase, and prevents lipid peroxidation of human serum. This compound also inhibits radiation-induced cellular damage by preventing DNA strand breakage. It may be effective in treating diseases related to oxidative stress, such as diabetes and cancer.

Biosynthesis

The biosynthesis of Pyrroloquinoline quinone disodium salt (PQQ) as follows: starting from Hyphomicrobium denitrificans FJNU-6, a high-yielding and genetically stable mutant strain FJNU-A26 was obtained by combining ARTP (atmospheric and room temperature plasma) mutagenesis, adaptive laboratory evolution (ALE), and high-throughput screening; the strain was then cultivated in a five-component medium containing methanol (20 g/L), ammonium sulfate, potassium dihydrogen phosphate, and disodium hydrogen phosphate, whose composition was optimized first by one-factor-at-a-time experiments and then by response surface methodology (Box–Behnken design), raising PQQ concentration from 1.02 g/L to 1.37 g/L; finally, fed-batch fermentation was carried out in a 5-L bioreactor (2.5 L working volume, 30 °C) with a two-stage oxygen supply strategy (60% before 55 h, 40% after 55 h) and a two-stage pH control (initial pH 6.5 favoring cell growth, shifted to pH 7.0 after 40 h to promote PQQ synthesis), reaching a PQQ concentration of 1.52 g/L, a yield of 40.3 mg/g DCW, and a volumetric productivity of 10.5 mg/L·h after 144 h, a 148% increase over the original strain [1].

benefits

1.Antioxidant. PQQ (pyrroloquinoline quinone) is an antioxidant and based on research, it shows to be more powerful at fighting free radicals than vitamin C. Antioxidants work better together, so it is unclear if taking PQQ alone as a supplement can help stop any diseases.
2.Mitochondrial dysfunction. Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. One study tested PQQ supplements in men who did aerobic exercise for 6 weeks. It increased mitochondria by affecting certain proteins during exercise. Another study showed that dietary PQQ raised mitochondria activity.
3.Anti-diabetes. Problems with mitochondria are part of what causes diabetes. Animal data shows that PQQ supplements fix mitochondrial problems from diabetes and make diabetic mice respond better to insulin. Yet, there isn’t any evidence that PQQ can help people with diabetes.
4.Inflammation. PQQ might lower inflammation by lowering the C-reactive protein, interleukin-6, and other markers in your blood.
5.Nootropic. Substances that help memory, attention, and learning are sometimes called nootropics. Studies show that PQQ raises blood flow to the cerebral cortex. This supplement also may also memory problems in older people. Sleep and mood. PQQ might help with better and longer sleep. By easing fatigue, it might also help to improve moods.

Source

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.

Biological Functions

In bacteria, pyrroloquinoline quinone disodium salt (PQQ-NA2) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.

Side effects

From Self-Hacked: Anecdotally, some people have reported mild headaches and insomnia – usually either if too much is taken or if someone is very sensitive to the effects of supplements.
From Dr. Axe: The most commonly reported pyrroloquinoline quinone side effects include headaches, drowsiness and fatigue. Extremely high doses can also be dangerous and have actually been associated with some serious and potentially life-threatening effects on health.
keep.health/pqq-pyrroloquinoline-quinone/

References

[1] Ren, Y., Yang, X., Ding, L., Liu, D., Tao, Y., Huang, J., Ke, C. (2023). Adaptive evolutionary strategy coupled with an optimized biosynthesis process for the efficient production of pyrroloquinoline quinone from methanol. Biotechnology for Biofuels and Bioproducts, 16(1). https://doi.org/10.1186/s13068-023-02261-y

Pyrroloquinoline quinone disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrroloquinoline quinone disodium salt Suppliers

Global( 492)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing pathgene biotech co .,ltd 		+86-13342904611 +86-13342904611 alex@pathgenebio.com China 65 58
Shaanxi LonierHerb Bio Technology Co Ltd
+86-86-+86-86-029-87551862 15002946897 1713330907@QQ.com China 2635 58
Maintain Biotech Co., Ltd.
+86-75589664337 +86-15112661142 cami@maintain-bio.com China 97 58
ZhenYiBio Technology Inc
+8615309206328 alexxue@zhenyibio.com China 298 58
Shangdong Yuanlitai Nutratech Co.,ltd
18782242822 tatiana@yltnutra.com China 8 58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
+86-57182358004 +86-13588810720 sales1@weitai-pharmaceutical.com France 71 58
GIHI CHEMICALS CO.,LIMITED
+86-571-86217390; +8618058761490 info@gihichemicals.com China 49860 58
Zhejiang Hengkang Pharmaceutical Co.Ltd.
+86-13858064988 commercial@hengkangpharm.cn China 49 58
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
+86-0086-13751168070 +86-19925801629 sales@huarongpharma.com China 185 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5214 58
Supplier Advantage
Nanjing pathgene biotech co .,ltd 		58
Shaanxi LonierHerb Bio Technology Co Ltd
58
Maintain Biotech Co., Ltd.
58
ZhenYiBio Technology Inc
58
Shangdong Yuanlitai Nutratech Co.,ltd
58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)
58
GIHI CHEMICALS CO.,LIMITED
58
Zhejiang Hengkang Pharmaceutical Co.Ltd.
58
HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
58
Hebei Chuanghai Biotechnology Co,.LTD 		58

Related articles

Related Questions

Ask a question
Q:Has pyrroloquinoline quinone disodium salt been approved by the FDA?STAR - Dec 23,2025
A:Yes. Pyrroloquinoline quinone disodium salt (PQQ) is a red trihydrate crystal that was approved as a new food ingredient by FDA in 2008. Now, it is approved as a food in Japan and the EU. PQQ has redox properties and exerts antioxidant, neuroprotective, and mitochondrial biogenesis effects. The baseline intake level of PQQ is considered to be 20 mg/day. PQQ ingestion lowers blood lipid peroxide levels in humans, suggesting antioxidant activity. In the field of cognitive function, double-blind, placebo-controlled trials have been conducted. Various improvements have been reported regarding general memory, verbal memory, working memory, and attention. Furthermore, a stratified analysis of a population with a wide range of ages revealed unique effects in young people (20-40 years old) that were not observed in older adults (41-65 years old). Specifically, cognitive flexibility and executive speed improved more rapidly in young people at 8 weeks. Co-administration of PQQ and coenzyme Q10 further enhanced these effects. In an open-label trial, PQQ was shown to improve sleep and mood. Additionally, PQQ was found to suppress skin moisture loss and increase PGC-1α expression. Overall, PQQ is a food with various functions, including brain health benefits.

View Lastest Price from Pyrroloquinoline quinone disodium salt manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyrroloquinoline Quinone Disodium Salt（PQQ） pictures 2026-09-09 Pyrroloquinoline Quinone Disodium Salt（PQQ）
122628-50-6
 1kg 0.99 20tons HANGZHOU INVERTIN BIOPHARMA CO., LTD.
Pyrroloquinoline Quinone Disodium Salt Powder pictures 2026-09-09 Pyrroloquinoline Quinone Disodium Salt Powder
122628-50-6
 1kg 98% 1000 Changsha Staherb Natural Ingredients Co., Ltd.
Pyrroloquinoline Quinone Disodium Salt(PQQ) pictures 2026-09-09 Pyrroloquinoline Quinone Disodium Salt(PQQ)
122628-50-7
 $1.00 25KG 99% 20T HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD

122628-50-6(Pyrroloquinoline quinone disodium salt)Related Search:

3-METHYL-4-PYRIDINECARBOXYLIC ACID 2-FORMYL-5-PICOLINE 4-Acetyl-1H-pyrrole-2-carboxylic acid 2,6-DIMETHYLPYRIDINE-4-CARBOXALDEHYDE (6-ethylpyridin-2-yl)methanol
2-Propionylpyridine 5-METHYLPICOLINIC ACID 2,6-DIMETHYLISONICOTINIC ACID 6-METHYL-2-PYRIDINEMETHANOL 1-PYRIDIN-2-YL-PROPAN-2-ONE
6-Methyl-2-pyridinecarboxylic acid 3-METHYL-2-PYRIDINECARBOXALDEHYDE 4-METHYL-PYRIDINE-2-CARBOXYLIC ACID 1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE 2-Acetyl-4-methylpyridine
2-Pyridinecarboxaldehyde, 6-acetyl- (9CI) Pyrroloquinoline quinone 1-Tetradecanol

1of4

disodium4,5-dihydro-4,5-dioxo-1h-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylat PQQ, Pyrrolo-quinoline-quinone disodium salt sodiuM 9-carboxy-4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7-dicarboxylate 1H-Pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylicacid, 4,5-dihydro-4,5-dioxo-, sodium salt PYRROLOQUINOLINE QUINONE DISODIUM SALTPYRROLOQUINOLINE QUINONE DISODIUM SALT PYRROLOQUINOLINE QUINONE DISODIUM SALT METHOXATIN DISODIUM SALT 3-f)quinoline-2,7,9-tricarboxylicacid,4,5-dihydro-4,5-dioxo-1h-pyrrolo(di 1H-Pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylicacid Methoxatin Disodium Pyrroloquinoline Quinone Disodium Salt 122628-50-6 DISODIUM 2-CARBOXY-4,5-DIOXO-1H-PYRROLO[2,3-F]QUINOLINE-7,9-DICARBOXYLATE Pyrroloquinoline Quinine Disodium Salt Pyrroloquinoline quinone sodium salt PYROLOQUINOLINE QUINONE DISODIUM SALT Pyrroloquinoline Quinone Disodium (PQQ Disodium) 1H-Pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylicacid, 4,5-dihydro-4,5-dioxo-, sodium salt (1:2) Methoxatin disodium salt >=97.0% (HPLC) Pyrroloquinoline quinone(PQQ) disodium salt PQQ DISODIUM SALT PQQ Methoxatindisodiumsal Pyrrolloquinoline Quinone Disodium Salt Pyrroquinoline benzoquinone sodium salt PQQ (Pyrroloquinoline quinone) Pyrroloquinoline Quinone Disodium Salt(PQQ) Pyrroloquinoline Quinone Disodium Salt Powder disodium pyrroloquinolinedione tricarboxylate PQQ (Methoxatin disodium salt) 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid disodium salt Pyrroloquinoline Benzoquinone Sodium Salt PQQ Disodium Salt>99% Pyrroloquinoline quinone sodium salt (PQQ) Pyrroliquinoline quinone sodium salt SodiumPyrroloquinolineQuinone/PQQ Pyrroloquinoline quinone disodium sal Pyrroloquinoline quinone disodium salt PQQ-NA2 Pyrroloquinoline quinone disodium salt (PQQ-2Na) Pyrroloquinolinequinone disodium PQQ pentyl (1-(3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate Pyrroliquinoline quinone disodium salt(PQQ) MedChemExpress PQQ disodium PQQ-2Na PQQ Disodium Salt pyrroloquinoline quineone Liposomal PQQ Disodium Salt (Pyrroloquinoline Quinone Disodium) 122628-50-6 122628-50-7 C14H4N2O82Na C14H4N2Na2O8 Biochemicals and Reagents BioChemical Enzymes, Inhibitors, and Substrates Cofactors Oxidation-Reduction PQQ 122628-50-6