Rebaudioside A
- CAS No.
- 58543-16-1
- Chemical Name:
- Rebaudioside A
- Synonyms
- REBAUDIOSIDE;Steviol Glycoside;Reb A;4G-S;Rebiana;Reb-A 97;Pure Via;Glycoside X;Lebaldide A;Glycoside A3
- CBNumber:
- CB3736050
- Molecular Formula:
- C44H70O23
- Molecular Weight:
- 967.01
- MDL Number:
- MFCD02183463
- MOL File:
- 58543-16-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Rebaudioside A phyproof? Reference Substance | PHL80067 | 20MG | $315 |
| Rebaudioside A United States Pharmacopeia (USP) Reference Standard | 1600121 | 500mg | $672 |
| Rebaudioside A ≥96% (HPLC) | 01432 | 10g | $147 |
| Rebaudioside A >98.0%(HPLC) | R0095 | 5g | $69 |
| Rebaudioside A >98.0%(HPLC) | R0095 | 25g | $242 |
| More product size | |||
| Melting point | 235°C(lit.) |
|---|---|
| Boiling point | 1102.8±65.0 °C(Predicted) |
| Density | 1.59±0.1 g/cm3(Predicted) |
| vapor pressure | 0-1198Pa at 20-50℃ |
| refractive index | 1.662 |
| FEMA | 4601 | REBAUDIOSIDE A |
| FLAVIS Number | 16.113 | Rebaudioside A |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Sparingly) |
| form | Solid |
| pka | 12.51±0.70(Predicted) |
| color | White to Off-White |
| Odor | Mild odor |
| optical activity | [α]/D -33.0±3.0°, c = 1% in H2O |
| biological source | plant |
| Water Solubility | water: soluble |
| BRN | 6470556 |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChIKey | HELXLJCILKEWJH-NCGAPWICSA-N |
| LogP | -1-2.61 at 20-25℃ and pH7 |
| Substances Added to Food (formerly EAFUS) | REBAUDIOSIDE A |
| FDA UNII | B3FUD0528F |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | NZ8174800 |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
Rebaudioside A price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80067 | Rebaudioside A phyproof? Reference Substance | 58543-16-1 | 20MG | $315 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1600121 | Rebaudioside A United States Pharmacopeia (USP) Reference Standard | 58543-16-1 | 500mg | $672 | 2026-04-30 | Buy |
| Sigma-Aldrich | 01432 | Rebaudioside A ≥96% (HPLC) | 58543-16-1 | 10g | $147 | 2026-04-30 | Buy |
| TCI Chemical | R0095 | Rebaudioside A >98.0%(HPLC) | 58543-16-1 | 5g | $69 | 2026-04-30 | Buy |
| TCI Chemical | R0095 | Rebaudioside A >98.0%(HPLC) | 58543-16-1 | 25g | $242 | 2026-04-30 | Buy |
Rebaudioside A Chemical Properties,Uses,Production
Description
Rebaudioside A is a natural non-caloric sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. In a two bottle preference test, mice drink more water containing rebaudioside A than unsweetened water, though saccharin-sweetened water is still preferred. Rebaudioside A is metabolized by gut microbiota to steviol , a compound whose safety is widely studied. Consumption of rebaudioside A formulations by pre-diabetic patients did not increase fasting or 2 hour plasma glucose levels or insulin levels.
Chemical Properties
White powder
Uses
Rebaudioside A is a glycoside from the stevia plant. Rebaudioside A is used as a sweetener with sweetness about 300 times that of sugar with negligible effect on blood glucose. As a result, Rebaudiosi de A is known for its application in treatment of many diseases like diabetes, high blood pressure and weight loss in some places. It is used as a food additive and in dietary supplements.
Uses
natural sweetener to diabetics and others on carbohydrate-controlled diets
Uses
Rebaudioside A is a natural, highly processed calorie free sweetener obtained from the leaves of the plant stevia rebaudiana bertoni. it is a steviol glycoside in which the steviol’s carboxyl and hydroxyl hydrogen atom is replaced with glucose, it has three linked glucose molecules at the hydroxyl site. rebaudiana (reb a) is 300–400 times sweeter than sugar and the least bitter of the glycosides. it is ph and heat stable with good solubility in water. uses include beverages, table top sweetener, general foods. it is also termed reb a, stevia extract, stevia.
Definition
Rebaudioside A is a rebaudioside that is rubusoside in which the hydroxy groups at positions 3 and 4 of the beta-D-glucopyranosyloxy group at the 13alpha position have both been converted to the corresponding beta-D-glucopyranoside. It has a role as a sweetening agent. It is a beta-D-glucoside, a tetracyclic diterpenoid and a rebaudioside. It derives from a rubusoside and a beta-D-Glcp-(1->2)-[beta-D-Glcp-(1->3)]-beta-D-Glcp.
benefits
Zero calories
No carbohydrate
Does not raise blood glucose or insulin levels (Zero Index Glycemic), safe for people with diabetes
Keto, Vegan, and Gluten-Free
Biological Activity
Rebaudioside A is a natural non-caloric sweetener. It is one of the predominant steviol glycosides isolated from S. rebaudiana leaves. It increases glucagon-like peptide 1 (GLP-1) secretion in a 2-dimensional mouse intestine model. In a two bottle preference test, mice drink more water containing rebaudioside A than unsweetened water, though saccharin-sweetened water is still preferred. Rebaudioside A is metabolized by gut microbiota to steviol, a compound whose safety is widely studied. Consumption of rebaudioside A formulations by pre-diabetic patients did not increase fasting or 2 hour plasma glucose levels or insulin levels.
Safety
High-purity (95% minimum) of individual or combined steviol glycosides can be considered as GRAS (Generally Recognized as Safe) by the FDA. For example, FDA had no questions regarding Guilin Layn's conclusion that its reb A (≥97% by weight (w/w)) is GRAS as a table top sweetener and as a general purpose sweetener in foods, excluding meat and poultry products and infant formulas.
Its safety has also been approved by the EFSA, JECFA, FSANZ and other authorities.
Synthesis
57817-89-7
57-50-1
58543-16-1
A new structure based on (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl((4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R )-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methylcyclohepta[a]naphthalene-4-carboxylic acid ester and sucrose were used as raw materials, and the general procedure for the synthesis of rebaudioside A was as follows: firstly, the expression in E. coli of pEUGT- SUS vector in E. coli, followed by collecting the cells and washing them twice with potassium phosphate buffer (100 mM, pH 7.2). Next, the cells were broken by sonication in an ice-water bath and centrifuged at 4°C to remove cellular debris to obtain a lysate supernatant containing soluble proteins. This supernatant is the crude extract. The total protein concentration of the crude extract was determined by the Bradford method using bovine serum albumin (BSA) as a standard. Finally, rebaudioside A was synthesized by reacting the substrate acaricide with an equal volume of the crude extract in potassium phosphate buffer (100 mM, pH 7.2) containing different concentrations of UDP-glucose or UDP, sucrose, and 3 mM MgCl2 at 30 °C.
References
[1] Bioscience, Biotechnology and Biochemistry, 2016, vol. 80, # 1, p. 67 - 73
Rebaudioside A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6367 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
View Lastest Price from Rebaudioside A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | Rebaudioside A; stevia?rebaudiana extract
58543-16-1
|
US $0.00 / KG | 1KG | ≥98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2026-05-11 | Rebaudioside A
58543-16-1
|
US $29.00 / mL | 98.79% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | REBAUDIOSIDE A
58543-16-1
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Rebaudioside A; stevia?rebaudiana extract
58543-16-1
- US $0.00 / KG
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Rebaudioside A
58543-16-1
- US $29.00 / mL
- 98.79%
- TargetMol Chemicals Inc.
-
- REBAUDIOSIDE A
58543-16-1
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
