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2-Fluoro-5-methylpyridine

2-Fluoro-5-methylpyridine structure

CAS No.: 2369-19-9

Chemical Name:: 2-Fluoro-5-methylpyridine

Synonyms: 2-Fluoro-5-m;uoro-5-methyL;6-FLUORO-3-PICOLINE;2-FLUORO-5-PICOLINE;Fluoromethylpyridine3;2-FLUORO-5-METHYPYRIDINE;2-Bromo-1-methylpyridine;2-FLUORO-5-METHYLPYRIDINE;2-Fluoro-5-methylpyridine97%;2-Fluoro-5-methylpyridine>

CBNumber:: CB3742934

Molecular Formula:: C6H6FN

Molecular Weight:: 111.12

MDL Number:: MFCD00041225

MOL File:: 2369-19-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:43

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2-Fluoro-5-methylpyridine Properties

Boiling point	158-159 °C (lit.)
Density	1.072 g/mL at 25 °C (lit.)
refractive index	n20/D 1.4730(lit.)
Flash point	119 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-0.14±0.10(Predicted)
form	Liquid
Specific Gravity	1.077
color	Colorless to pale yellow
BRN	107085
InChI	InChI=1S/C6H6FN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
InChIKey	AOSOZARHUJMBLZ-UHFFFAOYSA-N
SMILES	C1(F)=NC=C(C)C=C1
CAS DataBase Reference	2369-19-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

Hazard Codes

Xi,F

Risk Statements

10-36/37/38

Safety Statements

16-26-36/37-36

RIDADR

UN 1993 3/PG 3

WGK Germany

Hazard Note

Flammable/Irritant

HazardClass

PackingGroup

III

HS Code

29333990

NFPA 704

	2
2		0

2-Fluoro-5-methylpyridine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	595136	2-Fluoro-5-methylpyridine 97%	2369-19-9	1g	$44.4	2023-06-20	Buy
TCI Chemical	F0581	2-Fluoro-5-methylpyridine >98.0%(GC)	2369-19-9	1g	$30	2025-07-31	Buy
TCI Chemical	F0581	2-Fluoro-5-methylpyridine >98.0%(GC)	2369-19-9	5g	$87	2025-07-31	Buy
TRC	F600073	2-Fluoro-5-methylpyridine	2369-19-9	2.5g	$45	2021-12-16	Buy
TRC	F600073	2-Fluoro-5-methylpyridine	2369-19-9	5g	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
595136	1g	$44.4	Buy
F0581	1g	$30	Buy
F0581	5g	$87	Buy
F600073	2.5g	$45	Buy
F600073	5g	$60	Buy

2-Fluoro-5-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

liquid

Synthesis

1603-41-4

2369-19-9

To a solution of 2-amino-5-methylpyridine (13) (20.0 g, 185 mmol) in fluoboric acid (50 wt% aqueous solution, 50 mL) was added sodium nitrite (16.6 g, 240 mmol) in batches at -10 °C while controlling the temperature of the reaction to be below 0 °C. After addition, the reaction mixture was stirred at 0 °C for 30 min, then warmed to 50 °C and continued stirring for 30 min. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted to 9-10 with saturated aqueous sodium carbonate solution (250 mL), followed by extraction with dichloromethane (4 x 125 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by alumina column chromatography (eluent: dichloromethane) to afford 2-fluoro-5-methylpyridine (14) (7.50 g, 69 mmol) as a yellow oil in 37% yield. Thin-layer chromatography (TLC) analysis: Rf (Al2O3, dichloromethane) 0.92. Infrared spectra (IR, NaCl plate) νmax: 1246, 1379, 1486, 2929 cm-1. nuclear magnetic resonance hydrogen spectra (1H NMR, 200 MHz, CDCl3) δ: 2.25 (s, 3H, CH3), 6.75 (dd, 1H, J = 8.2 Hz, 3JH-F = 3.0 Hz, H-3), 7.52 (m, 1H, H-4), 7.94 (s, 1H, H-6). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ: 17.4 (CH3), 108.8 (d, 2JC-F = 38Hz, C-3), 130.6 (C-5), 141.7 (d, 3JC-F = 8Hz, C-4), 147.2 (d, 3JC-F = 14Hz, C-6), 162.1 (d. 1JC-F = 236Hz, C-2).

References

[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 345 - 348
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 1125
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[5] Patent: US5583148, 1996, A

2-Fluoro-5-methylpyridine synthesis

Synthesis of 2-Fluoro-5-methylpyridine from 2-Amino-5-methylpyridine

2-Fluoro-5-methylpyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Sodium nitrite Fluoroboric acid 2-ACETAMIDO-5-PICOLINE 2-Fluoro-3-methylpyridine

2-ACETAMIDO-3-PICOLINE 3-Picoline Acetonitrile

1of2

Preparation Products

5-(BROMOMETHYL)-2-FLUOROPYRIDINE 6-Fluoronicotinic acid

2-Fluoro-5-methylpyridine Suppliers

Global( 355)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20202	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from 2-Fluoro-5-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-08	2-Fluoro-5-methylpyridine 2369-19-9	US $100.00 / KG	1KG	99%	5000KG/week	Hebei Mujin Biotechnology Co.,Ltd
2025-07-25	2-Fluoro-5-methylpyridine 2369-19-9	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	2-Fluoro-5-methylpyridine 2369-19-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

2-Fluoro-5-methylpyridine
2369-19-9
US $100.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

2-Fluoro-5-methylpyridine
2369-19-9
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Fluoro-5-methylpyridine
2369-19-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

2-Fluoro-5-methylpyridine Spectrum

2-Fluoro-5-methylpyridine(2369-19-9)¹HNMR

2369-19-9(2-Fluoro-5-methylpyridine)Related Search:

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2-FLUORO-4-METHYLPYRIDINE 98%,2-Fluoro-4-methylpyridine/2-Fluoro-4-Picoline 5-BROMO-2-FLUORO-6-PICOLINE 5-BROMO-2-FLUORO-3-METHYLPYRIDINE 2-FLUORO-3-METHYLPYRIDINE 97% 2-FLUORO-6-METHYLPYRIDINE 98%,2-Fluoro-6-methylpyridine/2-Fluoro-6-Picoline

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Fluoromethylpyridine3 2-FLUORO-5-METHYLPYRIDINE 99% 2-FLUORO-5-METHYLPYRIDINE 2-FLUORO-5-PICOLINE 6-FLUORO-3-PICOLINE 2-Fluoro-5-methylpyridine/2-Fluoro-5-Picoline 2-Fluoro-5-methylpyridine97% 2-Fluoro-5-methylpyridine≥ 99% (GC) 2-Fluoro-5-m 2-FLUORO-5-METHYPYRIDINE 2-Fluoro-5-methylpyridine ,99% 2-Fluoro-5-methylpyridine> uoro-5-methyL Pyridine, 2-fluoro-5-methyl- 2-Bromo-1-methylpyridine 2-Fluoro-5-methylpyridine ISO 9001：2015 REACH 2369-19-9 369-19-9 C6H6NF Building Blocks Pyridines Heterocyclic Building Blocks C6 Fluorine series Thiophenes Building Blocks Chemical Synthesis Fluorinated Building Blocks Heterocyclic Building Blocks Heterocyclic Fluorinated Building Blocks Other Fluorinated Heterocycles blocks Pyridines Pyridine pharmacetical Fluoropyridines Halopyridines Boronic Acid Heterocyclic Building Blocks Fluorin-contained pyridine series C6