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2-Fluoro-5-methylpyridine

2-Fluoro-5-methylpyridine Structure
2-Fluoro-5-methylpyridine structure
CAS No.
2369-19-9
Chemical Name:
2-Fluoro-5-methylpyridine
Synonyms
2-Fluoro-5-m;uoro-5-methyL;6-FLUORO-3-PICOLINE;2-FLUORO-5-PICOLINE;Fluoromethylpyridine3;2-FLUORO-5-METHYPYRIDINE;2-Bromo-1-methylpyridine;2-FLUORO-5-METHYLPYRIDINE;2-Fluoro-5-methylpyridine97%;2-Fluoro-5-methylpyridine>
CBNumber:
CB3742934
Molecular Formula:
C6H6FN
Molecular Weight:
111.12
MDL Number:
MFCD00041225
MOL File:
2369-19-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:24
Product description Number Pack Size Price
2-Fluoro-5-methylpyridine 97% 595136 1g $44.4
2-Fluoro-5-methylpyridine >98.0%(GC) F0581 1g $22
2-Fluoro-5-methylpyridine >98.0%(GC) F0581 5g $70
2-Fluoro-5-methylpyridine F600073 2.5g $45
2-Fluoro-5-methylpyridine F600073 5g $60
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2-Fluoro-5-methylpyridine Properties

Boiling point 158-159 °C (lit.)
Density 1.072 g/mL at 25 °C (lit.)
refractive index n20/D 1.4730(lit.)
Flash point 119 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.14±0.10(Predicted)
form Liquid
color Colorless to pale yellow
Specific Gravity 1.077
BRN 107085
InChI InChI=1S/C6H6FN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
InChIKey AOSOZARHUJMBLZ-UHFFFAOYSA-N
SMILES C1(F)=NC=C(C)C=C1
CAS DataBase Reference 2369-19-9(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,F
Risk Statements  10-36/37/38
Safety Statements  16-26-36/37-36
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Flammable/Irritant
HazardClass  3
PackingGroup  III
HS Code  29333990
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

2-Fluoro-5-methylpyridine price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 595136 2-Fluoro-5-methylpyridine 97% 2369-19-9 1g $44.4 2023-06-20 Buy
TCI Chemical F0581 2-Fluoro-5-methylpyridine >98.0%(GC) 2369-19-9 1g $22 2026-03-19 Buy
TCI Chemical F0581 2-Fluoro-5-methylpyridine >98.0%(GC) 2369-19-9 5g $70 2026-03-19 Buy
TRC F600073 2-Fluoro-5-methylpyridine 2369-19-9 2.5g $45 2021-12-16 Buy
TRC F600073 2-Fluoro-5-methylpyridine 2369-19-9 5g $60 2021-12-16 Buy
Product number Packaging Price Buy
595136 1g $44.4 Buy
F0581 1g $22 Buy
F0581 5g $70 Buy
F600073 2.5g $45 Buy
F600073 5g $60 Buy

2-Fluoro-5-methylpyridine Chemical Properties,Uses,Production

Chemical Properties

liquid

Synthesis

2-Amino-5-methylpyridine

1603-41-4

2-Fluoro-5-methylpyridine

2369-19-9

To a solution of 2-amino-5-methylpyridine (13) (20.0 g, 185 mmol) in fluoboric acid (50 wt% aqueous solution, 50 mL) was added sodium nitrite (16.6 g, 240 mmol) in batches at -10 °C while controlling the temperature of the reaction to be below 0 °C. After addition, the reaction mixture was stirred at 0 °C for 30 min, then warmed to 50 °C and continued stirring for 30 min. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted to 9-10 with saturated aqueous sodium carbonate solution (250 mL), followed by extraction with dichloromethane (4 x 125 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by alumina column chromatography (eluent: dichloromethane) to afford 2-fluoro-5-methylpyridine (14) (7.50 g, 69 mmol) as a yellow oil in 37% yield. Thin-layer chromatography (TLC) analysis: Rf (Al2O3, dichloromethane) 0.92. Infrared spectra (IR, NaCl plate) νmax: 1246, 1379, 1486, 2929 cm-1. nuclear magnetic resonance hydrogen spectra (1H NMR, 200 MHz, CDCl3) δ: 2.25 (s, 3H, CH3), 6.75 (dd, 1H, J = 8.2 Hz, 3JH-F = 3.0 Hz, H-3), 7.52 (m, 1H, H-4), 7.94 (s, 1H, H-6). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ: 17.4 (CH3), 108.8 (d, 2JC-F = 38Hz, C-3), 130.6 (C-5), 141.7 (d, 3JC-F = 8Hz, C-4), 147.2 (d, 3JC-F = 14Hz, C-6), 162.1 (d. 1JC-F = 236Hz, C-2).

References

[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 345 - 348
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 1125
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[5] Patent: US5583148, 1996, A

2-Fluoro-5-methylpyridine synthesis

1603-41-4
2369-19-9
Synthesis of 2-Fluoro-5-methylpyridine from 2-Amino-5-methylpyridine

2-Fluoro-5-methylpyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Sodium nitrite Fluoroboric acid 2-ACETAMIDO-5-PICOLINE 2-Fluoro-3-methylpyridine
2-ACETAMIDO-3-PICOLINE 3-Picoline Acetonitrile

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Preparation Products

5-(BROMOMETHYL)-2-FLUOROPYRIDINE 6-Fluoronicotinic acid

2-Fluoro-5-methylpyridine Suppliers

Global( 361)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 880 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21591 55
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Fluoropharm Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Shanghai Arbor Chemical Co., Ltd. 		58

View Lastest Price from 2-Fluoro-5-methylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Fluoro-5-methylpyridine pictures 2025-12-01 2-Fluoro-5-methylpyridine
2369-19-9
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Fluoro-5-methylpyridine pictures 2025-11-18 2-Fluoro-5-methylpyridine
2369-19-9
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Fluoro-5-methylpyridine pictures 2025-09-25 2-Fluoro-5-methylpyridine
2369-19-9
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

2-Fluoro-5-methylpyridine Spectrum

2-Fluoro-5-methylpyridine(2369-19-9)1HNMR

2369-19-9(2-Fluoro-5-methylpyridine)Related Search:

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2-FLUORO-4-METHYLPYRIDINE 98%,2-Fluoro-4-methylpyridine/2-Fluoro-4-Picoline 5-BROMO-2-FLUORO-6-PICOLINE 5-BROMO-2-FLUORO-3-METHYLPYRIDINE 2-FLUORO-3-METHYLPYRIDINE 97% 2-FLUORO-6-METHYLPYRIDINE 98%,2-Fluoro-6-methylpyridine/2-Fluoro-6-Picoline
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Fluoromethylpyridine3 2-FLUORO-5-METHYLPYRIDINE 99% 2-FLUORO-5-METHYLPYRIDINE 2-FLUORO-5-PICOLINE 6-FLUORO-3-PICOLINE 2-Fluoro-5-methylpyridine/2-Fluoro-5-Picoline 2-Fluoro-5-methylpyridine97% 2-Fluoro-5-methylpyridine≥ 99% (GC) 2-Fluoro-5-m 2-FLUORO-5-METHYPYRIDINE 2-Fluoro-5-methylpyridine ,99% 2-Fluoro-5-methylpyridine> uoro-5-methyL Pyridine, 2-fluoro-5-methyl- 2-Bromo-1-methylpyridine 2-Fluoro-5-methylpyridine ISO 9001：2015 REACH 2369-19-9 369-19-9 C6H6NF Building Blocks Pyridines Heterocyclic Building Blocks C6 Fluorine series Thiophenes Building Blocks Chemical Synthesis Fluorinated Building Blocks Heterocyclic Building Blocks Heterocyclic Fluorinated Building Blocks Other Fluorinated Heterocycles blocks Pyridines Pyridine pharmacetical Fluoropyridines Halopyridines Boronic Acid Heterocyclic Building Blocks Fluorin-contained pyridine series C6