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NEUROPEPTIDE FF

NEUROPEPTIDE FF Structure
NEUROPEPTIDE FF structure
CAS No.
99566-27-5
Chemical Name:
NEUROPEPTIDE FF
Synonyms
NPFF;NPAF;ninamide;F-8-F-NH2;FLFQPQRF-NH2;NEUROPEPTIDE FF;Neuropeptide FF TFA;Neuropeptide FF (cattle);Neuropeptide FF F-8-F-NH2;NEUROPEPTIDE FF USP/EP/BP
CBNumber:
CB3750458
Molecular Formula:
C54H76N14O10
Molecular Weight:
1081.27
MDL Number:
MFCD00076704
MOL File:
99566-27-5.mol
MSDS File:
SDS
Last updated:2025-08-20 16:56:14
Product description Number Pack Size Price
Neuropeptide FF (trifluoroacetate salt) ≥95% 24548 1mg $158
Neuropeptide FF 3137 1 $162
Neuropeptide FF 027103 96Tests $864
Neuropeptide FF 027102 96Tests $879
Neuropeptide FF 517495 96Tests $981
Request For Quotation

NEUROPEPTIDE FF Properties

storage temp. −20°C
solubility Water: 1 mg/ml
form Solid
color White to off-white
Water Solubility Soluble to 0.50 mg/ml in water.
Sequence Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2

SAFETY

Risk and Safety Statements

WGK Germany  3

NEUROPEPTIDE FF price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24548 Neuropeptide FF (trifluoroacetate salt) ≥95% 99566-27-5 1mg $158 2024-03-01 Buy
Tocris 3137 Neuropeptide FF 99566-27-5 1 $162 2021-12-16 Buy
Usbiological 027103 Neuropeptide FF 99566-27-5 96Tests $864 2021-12-16 Buy
Usbiological 027102 Neuropeptide FF 99566-27-5 96Tests $879 2021-12-16 Buy
Usbiological 517495 Neuropeptide FF 99566-27-5 96Tests $981 2021-12-16 Buy
Product number Packaging Price Buy
24548 1mg $158 Buy
3137 1 $162 Buy
027103 96Tests $864 Buy
027102 96Tests $879 Buy
517495 96Tests $981 Buy

NEUROPEPTIDE FF Chemical Properties,Uses,Production

Description

Neuropeptide FF (NPFF) is a peptide expressed in the brain and spinal cord that shares a precursor protein with neuropeptide AF. NPFF is expressed primarily in the posterior pituitary, hypothalamus, and medulla. It is an agonist at NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively, for human recombinant receptors) that inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively). NPFF activates parvocellular neurons in the paraventricular nucleus (PVN) of the hypothalamus to stimulate oxytocin release from their projections in the brain stem, thereby regulating baroreflex control of heart rate. However, it inhibits magnocellular PVN neurons by enhancing GABAergic input. It is also found in plasma and exogenous administration briefly increases mean arterial pressure (MAP) by 40 mm Hg in rats, an effect that is only partially blocked by the norepinephrine competitor guanethidine and the α1-adrenergic receptor antagonist prazosin . NPFF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats. It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol.

Uses

Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects.

storage

Store at -20°C

References

[1] PERTTI PANULA  Krzysztof W  Antti A Aarnisalo. Neuropeptide FF, a mammalian neuropeptide with multiple functions[J]. Progress in Neurobiology, 1996, 48 4: Pages 461-479, 481-487. DOI: 10.1016/0301-0082(96)00001-9
[2] CATHERINE MOLLEREAU . Pharmacological characterization of human NPFF1 and NPFF2 receptors expressed in CHO cells by using NPY Y1 receptor antagonists[J]. European journal of pharmacology, 2002, 451 3: Pages 245-256. DOI: 10.1016/s0014-2999(02)02224-0
[3] JACK H JHAMANDAS V G. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation.[J]. ACS Applied Electronic Materials, 2013: 8. DOI: 10.3389/fendo.2013.00008
[4] BRYAN L. ROTH . Elevation of arterial pressure in rats by two new vertebrate peptides FLF QPQRF-NH2 and AGE GLSSPFWSLAAPQRF-NH2 which are immunoreactive to FMRF-NH2 antiserum[J]. Neuropeptides, 1987, 10 1: Pages 37-42. DOI: 10.1016/0143-4179(87)90087-4
[5] QINGYUN LIU. Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociception*[J]. The Journal of Biological Chemistry, 2001, 25 1: 36961-36969. DOI: 10.1074/jbc.m105308200
[6] JOLANTA KOTLINSKA  Jerzy S  Agnieszka Pachuta. Neuropeptide FF (NPFF) reduces the expression of cocaine-induced conditioned place preference and cocaine-induced sensitization in animals[J]. Peptides, 2008, 29 6: Pages 933-939. DOI: 10.1016/j.peptides.2008.01.008

NEUROPEPTIDE FF Preparation Products And Raw materials

Raw materials

Preparation Products

NEUROPEPTIDE FF Suppliers

Global( 124)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Cellmano Biotech Limited 		0551-65326643 18156095617 info@cellmano.com China 995 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
Hangzhou Go Top Peptide Biotech 		0571-88211921 sales1@gotopbio.com CHINA 2609 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634 Cecilia@youngshechem.com China 2345 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49968 58
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 		58
BOC Sciences 		58
Cellmano Biotech Limited 		58
career henan chemical co 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Hangzhou Go Top Peptide Biotech 		58
Chengdu Youngshe Chemical Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
GIHI CHEMICALS CO.,LIMITED 		58

View Lastest Price from NEUROPEPTIDE FF manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NEUROPEPTIDE FF pictures 2020-03-06 NEUROPEPTIDE FF
99566-27-5
 US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co

99566-27-5(NEUROPEPTIDE FF)Related Search:

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PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 F-8-F-NH2 ninamide phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylala POTASSIUM FERROCYANIDE TRIHYDRATE*ACS RE AGENT Neuropeptide FF F-8-F-NH2 phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 Neuropeptide FF F-8-F-NH2, NPFF, F-8-F-aMide F-8-F-NH2, NPFF, F-8-F-aMide ANTI-NPFF (C-TERM) antibody produced in rabbit FMRFamide-related peptides NPAF Neuropeptide FF (trifluoroacetate salt) L-Phenylalaninamide, L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-arginyl- Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide >=95% (HPLC) NEUROPEPTIDE FF USP/EP/BP Neuropeptide FF (cattle) FLFQPQRF-NH2 Neuropeptide FF trifluoroacetate salt (NPFF) Neuropeptide FF TFA Rabbit Anti-NPFF antibody Neuro Peptide FF、Morphine Modulating Neuro P 99566-27-5 C54H76N14O10 BioChemical Amino Acids and Peptides Biochemicals and Reagents Other Peptides Peptides Peptide