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Ursodeoxycholic-2,2,4,4-d4 acid

Ursodeoxycholic-2,2,4,4-d4 acid structure

CAS No.: 347841-46-7

Chemical Name:: Ursodeoxycholic-2,2,4,4-d4 acid

Synonyms: Ursodeoxycholic-d4 Acid;D4-Ursodeoxycholic Acid;2H4]-Ursodeoxycholic Acid;Ursodeoxycholic acid-2,2,4,4-d4;Ursodeoxycholic-2,2,4,4-d4 acid;Urosodeoxycholic Acid Impurity 28;Ursodeoxycholic Acid-D4 (Standard);Ursodeoxycholic acid-[d4] (Solution);Ursodiol-d4 (Ursodeoxycholic Acid-d4);Ursodeoxycholic Acid-2,2,4,4-d4 (Major)

CBNumber:: CB3755802

Molecular Formula:: C24H40O4

Molecular Weight:: 392.58

MDL Number:: MFCD01317390

MOL File:: 347841-46-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:11

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Ursodeoxycholic-2,2,4,4-d4 acid Properties

storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),
form	Solid
color	White to Off-White
Stability	Hygroscopic
UNSPSC Code	12352211
NACRES	NA.12
CAS Number Unlabeled	128-13-2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311
target organs	Eyes
WGK Germany	WGK 2
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1

Ursodeoxycholic-2,2,4,4-d4 acid price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21892	Ursodeoxycholic Acid-d4 ≥99%deuteratedforms(d₁-d₄)	347841-46-7	500μg	$81	2026-04-30	Buy
Cayman Chemical	31368	Ursodeoxycholic Acid-d4 MaxSpec® Standard ≥95%	347841-46-7	100μg	$129	2026-04-30	Buy
Cayman Chemical	21892	Ursodeoxycholic Acid-d4 ≥99%deuteratedforms(d₁-d₄)	347841-46-7	1mg	$152	2026-04-30	Buy
Cayman Chemical	21892	Ursodeoxycholic Acid-d4 ≥99%deuteratedforms(d₁-d₄)	347841-46-7	5mg	$633	2026-04-30	Buy
TRC	TRC-U850007-5MG	Ursodeoxycholic Acid-d4	347841-46-7	5mg	$225	2026-06-03	Buy

Product number	Packaging	Price	Buy
21892	500μg	$81	Buy
31368	100μg	$129	Buy
21892	1mg	$152	Buy
21892	5mg	$633	Buy
TRC-U850007-5MG	5mg	$225	Buy

Ursodeoxycholic-2,2,4,4-d4 acid Chemical Properties,Uses,Production

Description

Ursodeoxycholic acid-d₄ (UDCA-d₄) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC₅₀ value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.

Uses

Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.

References

[1] PAUL A DAWSON Saul J K. Intestinal transport and metabolism of bile acids.[J]. Journal of Lipid Research, 2015, 56 6: 1085-1099. DOI: 10.1194/jlr.r054114
[2] ANAND K DEO S M B. 3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid.[J]. Drug Metabolism and Disposition, 2009, 37 9: 1938-1947. DOI: 10.1124/dmd.109.027763
[3] R B KIM. Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity.[J]. Journal of Pharmacology and Experimental Therapeutics, 1999, 291 3: 1204-1209.
[4] C M RODRIGUES. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.[J]. Journal of Clinical Investigation, 1998, 101 12: 2790-2799. DOI: 10.1172/jci1325

Ursodeoxycholic-2,2,4,4-d4 acid Preparation Products And Raw materials

Raw materials

Preparation Products

Ursodeoxycholic-2,2,4,4-d4 acid Suppliers

Global( 57)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18188	56
Artis Biotech Co. Ltd.	18108108965 18108108965	sales@artisbio.com	China	2503	58
Chengdu Novel Biomedical Co., Ltd.	028-85255396 18302801538	cdnovell@163.com	China	2444	58
Nanjing Haolv Biotechnology Co.,Ltd	025-84622273 17361806303	kexin.zhou@haolvbiotech.com	China	3009	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-025-85560043 17301488900	info@synzest.com	China	9274	58
Zhejiang Huida Biotech Co., LTD	0571-89903022 18679456698	zilong@hizyme.com	China	8001	58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，	028-83243028 19136088901	sinostandards@163.com	China	4979	58

Supplier	Advantage
Clearsynth Labs Limited	58
Quality Control Solutions Ltd.	56
Artis Biotech Co. Ltd.	58
Chengdu Novel Biomedical Co., Ltd.	58
Nanjing Haolv Biotechnology Co.,Ltd	58
TargetMol Chemicals Inc.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58
Zhejiang Huida Biotech Co., LTD	58
ChengDu SinoStandards Bio-Tech Co.,Ltd. ，	58

View Lastest Price from Ursodeoxycholic-2,2,4,4-d4 acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	Ursodeoxycholic Acid-D4 347841-46-7	$105.00-342.00		99.75%	10g	TargetMol Chemicals Inc.

Ursodeoxycholic Acid-D4
347841-46-7
$105.00-342.00
99.75%
TargetMol Chemicals Inc.

347841-46-7(Ursodeoxycholic-2,2,4,4-d4 acid)Related Search:

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Ursodeoxycholic-d4 Acid (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,14S,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid (4R)-4-[(3R,5R,7S,8R,9S,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Ursodiol-d4 (Ursodeoxycholic Acid-d4) URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 100 UG/ML IN METHANOL Ursodeoxycholic acid-[d4] (Solution) URSODEOXYCHOLIC ACID (2,2,4,4-D4, 98%) 95% CHEMICAL PURITY Ursodeoxycholic Acid-d4 MaxSpec? Standard Ursodeoxycholic Acid-2,2,4,4-d4 (Major) (4R)-4-[(3R,5S,7S,8R,10S,13R,17R)-2,2,4,4-tetradeuterio-3,7-dihydroxy-10,13-dimethyl-3,5,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid Urosodeoxycholic Acid Impurity 28 2H4]-Ursodeoxycholic Acid URSODEOXYCHOLICACID(2,2,4,4-D4) IN METHANOL *Dronedarone Impurity 37 ( Tributylamine) Ursodeoxycholic acid-2,2,4,4-d4 Ursodeoxycholic Acid-d4: (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,4,4-d4 acid D4-Ursodeoxycholic Acid Ursodeoxycholic acid (2,2,4,4-D?, 98%) CP 95% Ursodeoxycholic acid (2,2,4,4-D?, 98%) 100 μg/mL in methanol Ursodeoxycholic Acid-D4 (Standard) Ursodeoxycholic-2,2,4,4-d4 acid 347841-46-7 C24H36D4O4 Bile Acids - 13C & 2H