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2-Benzoxazolinone

2-Benzoxazolinone structure

CAS No.: 59-49-4

Chemical Name:: 2-Benzoxazolinone

Synonyms: BENZOXAZOLONE;3H-BENZOOXAZOL-2-ONE;usafek-5429;USAF ek-5429;AKOS B029757;2-Benzoxaxolol;2-Benzoxazolol;2-BENZOXAZOLONE;Benzoxazolinone;Benzoxazole-2-ol

CBNumber:: CB3763735

Molecular Formula:: C7H5NO2

Molecular Weight:: 135.12

MDL Number:: MFCD00005716

MOL File:: 59-49-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
2-Benzoxazolinone 98%	157058	100g	$139
2-Benzoxazolinone >98.0%(GC)(T)	B0506	25g	$46
2-Benzoxazolinone	B315730	5g	$45
2-Benzoxazolinone	J20253	5g	$19
2-Benzoxazolinone 95+%	074325	10g	$36
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2-Benzoxazolinone Properties

Melting point	137-139 °C(lit.)
Boiling point	248.79°C (rough estimate)
Density	1.3124 (rough estimate)
refractive index	1.5800 (estimate)
Flash point	160 °C
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.50±0.70(Predicted)
form	Powder
color	Light beige to brown-gray
Water Solubility	soluble in hot water
BRN	119481
InChI	1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
InChIKey	ASSKVPFEZFQQNQ-UHFFFAOYSA-N
SMILES	O=C1Nc2ccccc2O1
LogP	1.160
CAS DataBase Reference	59-49-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	3X996Q809V
NIST Chemistry Reference	Benzoxazolone(59-49-4)
EPA Substance Registry System	2-Benzoxazolinone (59-49-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P280-P301+P312+P330-P302+P352+P312-P304+P340+P312

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

20/21/22-22-24/25-36/37/38

Safety Statements

36-24/25-26

RIDADR

2811

WGK Germany

RTECS

DM4905000

Hazard Note

Harmful

TSCA

TSCA listed

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral

Toxicity

LD50 orl-rat: 700 mg/kg MDCHAG 4(1),308,64

NFPA 704

	1
2		0

2-Benzoxazolinone price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	157058	2-Benzoxazolinone 98%	59-49-4	100g	$139	2023-01-07	Buy
TCI Chemical	B0506	2-Benzoxazolinone >98.0%(GC)(T)	59-49-4	25g	$46	2026-03-19	Buy
TRC	B315730	2-Benzoxazolinone	59-49-4	5g	$45	2021-12-16	Buy
AK Scientific	J20253	2-Benzoxazolinone	59-49-4	5g	$19	2021-12-16	Buy
Matrix Scientific	074325	2-Benzoxazolinone 95+%	59-49-4	10g	$36	2021-12-16	Buy

Product number	Packaging	Price	Buy
157058	100g	$139	Buy
B0506	25g	$46	Buy
B315730	5g	$45	Buy
J20253	5g	$19	Buy
074325	10g	$36	Buy

2-Benzoxazolinone Chemical Properties,Uses,Production

Chemical Properties

light beige to brown-grey powder. insoluble in water, soluble in benzene, chlorobenzene and other solvents.

Uses

2-Benzoxazolinone is used in the study of the antioxidant activity of heterocyclic chalcones, screening of hydrazines as inhibitors of immune suppressive enzyme indoleamine dioxygenase 1, design and the development of the inhibitors of nitric oxide synthases.

Preparation

2-benzoxazolinone synthesis method: add o-aminophenol, urea and solvent chlorobenzene into the reaction kettle, protect with nitrogen, the reaction temperature is 50～132 ℃, the reaction time is 6h, after the reaction is completed, it is cooled with ice brine, crystallized, Filter the finished product. It is also possible to use o-aminophenol to react with phosgene in the solvent chlorobenzene, quickly pass phosgene within 20 ~ 40 ° C, then heat up to 100 ~ 130 ° C, and then pass phosgene at a lower speed, after the reaction is completed, pass nitrogen to catch up. Phosgene, after work-up, can also obtain 2-benzoxazolinone.

Definition

ChEBI: 2-benzoxazolinone is a member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2. It has a role as an allelochemical and a phytoalexin.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 6, p. 123, 1969 DOI: 10.1002/jhet.5570060124
Synthetic Communications, 34, p. 735, 2004 DOI: 10.1081/SCC-120027722
Synthesis, p. 1032, 1983 DOI: 10.1055/s-1983-30616

General Description

2-Benzoxazolinone is a phytoanticipin and its biotransformation by endophytic fungi isolated from Aphelandra tetragona was studied. 2-Benzoxazolinone is a natural chemical produced by rye (Secale cereale) and has strong phytotoxic properties.

Chemical Reactivity

2-benzazolinone is chemically active. in its molecular structure, the hydrogen atom at the 3-position can undergo a methylolation reaction with formaldehyde, and the hydrogen at the 6-position of the benzene ring is easily replaced by chlorine. it is easy to open ring to generate 2-hydroxyphenylamino acid in strong alkaline medium.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx.

2-Benzoxazolinone Preparation Products And Raw materials

Raw materials

2-Aminophenol S,S-bis(1-phenyl-1H-tetrazol-5-yl) dithiocarbonate 1-Phenyltetrazole-5-thiol 2,3-DICHLORO-5-NITROPYRIDINE Salicylhydroxamic acid

3-Chloro-2-hydroxy-5-nitropyridine

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Preparation Products

2,6-Dichlorobenzoxazole (2-OXO-1,3-BENZOXAZOL-3(2H)-YL)ACETALDEHYDE 2(3H)-Benzoxazolone, 3-(3-hydroxypropyl)- 3-(2-CHLORO-ACETYL)-3H-BENZOOXAZOL-2-ONE [3-(3-CHLORO-9-OXA-1,2,10-TRIAZA-ANTHRACEN-10-YL)-PROPYL]-DIMETHYL-AMINE

2-Chloro-10-methyl-3,4-diazaphenoxazine 2(3H)-Benzoxazolone, 5-hydroxy-

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2-Benzoxazolinone Suppliers

Global( 383)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
HaBo Hong Kong Co., Limited.	+86-25-18512596065	info@habotech.com	CHINA	933	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
HaBo Hong Kong Co., Limited.	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 2-Benzoxazolinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-27	2-Benzoxazolinone 59-49-4	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-22	2-Benzoxazolinone 59-49-4	US $29.00 / g		99.93%	10g	TargetMol Chemicals Inc.
2026-03-20	2-Benzoxazolinone 59-49-4	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

2-Benzoxazolinone
59-49-4
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Benzoxazolinone
59-49-4
US $29.00 / g
99.93%
TargetMol Chemicals Inc.

2-Benzoxazolinone
59-49-4
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Benzoxazolinone Spectrum

2-Benzoxazolinone(59-49-4)MS 2-Benzoxazolinone(59-49-4)¹HNMR 2-Benzoxazolinone(59-49-4)¹³CNMR 2-Benzoxazolinone(59-49-4)IR1 2-Benzoxazolinone(59-49-4)IR2 2-Benzoxazolinone(59-49-4)IR3 2-Benzoxazolinone(59-49-4)Raman

59-49-4(2-Benzoxazolinone)Related Search:

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3-ACETYL-2-BENZOXAZOLINONE hyl)-2-benzoxazolinon bromchlorenone 6-METHOXY-2-BENZOXAZOLINONE,6-Methoxy-2-benzoxazolinone,98+%,2-Benzoxazolinone, 6-methoxy- 2-Benzoxazolinone, 5-chloro-,5-CHLORO-2-BENZOXAZOLINONE

5-chloro-6-hydroxy-2-benzoxazolinon 3-(2-CARBOXYETHYL)-2-BENZOXAZOLINONE 4-Acetyl-2-benzoxazolinone 1-METHYL-2-BENZIMIDAZOLINONE 6-BROMO-BENZOXAZOLINONE,6-Bromo-2-benzoxazolinone

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USAF ek-5429 usafek-5429 2,3-Dihydro-2-oxo-1,3-benzoxazole Benzoxazolin-2-one, 1,3-Benzoxazol-2(3H)-one 2-Benzooazolinone 2-Benzoxazolinone,98% BENZOXAZOLONE (2-BENZOXAZOLINONE) Benzoxazol-2(3H)-one 2-benzoxazolirlone 2,3-Dihydrobenzoxazole-2-one Benzoxazole-2-ol Benzoxazolin-2(3H)-one 2-Benzo[d]oxazolinone 3H-1,3-Benzoxazol-2-one Carbamic acid, (2-hydroxyphenyl)-, g-lactone Benzoxazolin-2-one, 2,3-Dihydro-2-oxo-1,3-benzoxazole 2-Benzoxazolinone 98% 3H-BENZOOXAZOL-2-ONE 1,3-BENZOXAZOL-2(3H)-ONE 2-HYDROXYBENZOXAZOLE 2-BENZOXAZOLINONE 2-BENZOXAZOLONE AKOS B029757 2 (3H)-BENZOXAZOLONE 2,3-DIHYDRO-1,3-BENZOXAZOL-2-ONE 2-Benzoxaxolol 2-Benzoxazolol 2-hydroxy-benzoxazol Benzoxazole, 2-hydroxy- Benzoxazolinone Carbamic acid, (2-hydroxyphenyl)-, gamma-lactone o-Phenylenecarbamate BENZOXAZOLONE LABOTEST-BB LT01409074 1,3-Benzoxazol-2(3H)-one 98% Chlorzoxazone Impurity 5 2-Benzoxazolinone > 2- benzoxazoline ketone Benzoxazolinone, 2- benzo[d]oxazol-2-ol 2-benzenebenzoazolelineone 59-49-4 Oxazoles Heterocyclic Building Blocks Building Blocks Oxazole&Isoxazole