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6-AMINOPHTHALIDE

6-AMINOPHTHALIDE structure

CAS No.: 57319-65-0

Chemical Name:: 6-AMINOPHTHALIDE

Synonyms: 6-Aminoisobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 6-amino-;6-AMINO-1,3-DIHYDROISOBENZOFURAN-1-ONE;RMA-283;6-Aminophtalide;6-AMINOPHTHALIDE;BUTTPARK 33\04-93;6-Aminophthalide,95%;6-Aminophthalide 97%;6-Aminophthalide 97%

CBNumber:: CB3771916

Molecular Formula:: C8H7NO2

Molecular Weight:: 149.15

MDL Number:: MFCD00033530

MOL File:: 57319-65-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:55:24

Product description	Number	Pack Size	Price
6-AMINOPHTHALIDE Aldrich^CPR	S745197	1 unit	$152
6-AMINOPHTHALIDE Aldrich	S745197	5mg	$139
6-Aminophthalide	437878	100mg	$305
6-Aminophthalide	437878	250mg	$432
6-Aminophthalide	HCA31965	5g	$295

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6-AMINOPHTHALIDE Properties

Melting point	183 °C
Boiling point	420.2±45.0 °C(Predicted)
Density	1.376±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	3.88±0.20(Predicted)
Appearance	White to yellow Solid
Water Solubility	Soluble in water 1360 mg/L 25°C.
InChI	InChI=1S/C8H7NO2/c9-6-2-1-5-4-11-8(10)7(5)3-6/h1-3H,4,9H2
InChIKey	ZIJZDNKZJZUROE-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C=CC(N)=C2)CO1
CAS DataBase Reference	57319-65-0(CAS DataBase Reference)
FDA UNII	BF6HH4UQR9

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

RIDADR

UN2811

Hazard Note

Irritant

HS Code

2932990090

NFPA 704

	1
2		0

6-AMINOPHTHALIDE price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S745197	6-AMINOPHTHALIDE Aldrich^CPR	57319-65-0	1 unit	$152	2026-04-30	Buy
Sigma-Aldrich	S745197	6-AMINOPHTHALIDE Aldrich	57319-65-0	5mg	$139	2024-03-01	Buy
Usbiological	437878	6-Aminophthalide	57319-65-0	100mg	$305	2026-06-03	Buy
Usbiological	437878	6-Aminophthalide	57319-65-0	250mg	$432	2026-06-03	Buy
Biosynth	HCA31965	6-Aminophthalide	57319-65-0	5g	$295	2026-06-04	Buy

Product number	Packaging	Price	Buy
S745197	1 unit	$152	Buy
S745197	5mg	$139	Buy
437878	100mg	$305	Buy
437878	250mg	$432	Buy
HCA31965	5g	$295	Buy

6-AMINOPHTHALIDE Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

It is used to produce 6-acetylamino-phthalide. It is also used as a starting material in the reduction reaction.

Uses

6-Aminophthalide is used in the total synthesis of uncialamycin and its application to antitumor antibiotics. Also used in permethyl ningalin analogs as P-glycoprotein inhibitors.

Definition

ChEBI: 6-Amino-1,3-dihydroisobenzofuran-1-one is a member of 2-benzofurans.

Synthesis

610-93-5

57319-65-0

General procedure for the synthesis of 6-aminophthalide from 6-nitrotetrachlorophthalide: Commercially available 6-nitro-1(3H)-isobenzofuranone (9.9 g, 55 mmol) was dissolved in a solvent mixture of tetrahydrofuran (20 mL) and methanol (60 mL), and 5% palladium-carbon catalyst (1.5 g) was subsequently added. The reaction mixture was stirred at room temperature for 20 h under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered and the solid was washed sequentially with ethyl acetate and methanol. The filtrate and washings were combined and the resulting solution was concentrated under reduced pressure. The resulting solid was washed with ethyl acetate to give 6-aminophthalide (6.21 g) as a crystalline solid. The washings were concentrated and the residue was crystallized by mixed ethyl acetate-hexane solvent to obtain additional 6-aminophthalide (0.95 g, 87% total yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CD3OD): δ 5.225 (2H, s), 7.060 (1H, d, J = 2 Hz), 7.071 (1H, dd, J = 9, 2 Hz), 7.288 (1H, d, J = 9 Hz). Infrared spectra (KBr pressed) νmax cm-1: 3473, 3372, 3278, 1735, 1631, 1504, 1330, 1059, 992.

References

[1] Physical Chemistry Chemical Physics, 2005, vol. 7, # 24, p. 4070 - 4081
[2] Chemistry - A European Journal, 2016, vol. 22, # 13, p. 4600 - 4607
[3] ACS Catalysis, 2014, vol. 4, # 10, p. 3504 - 3511
[4] Patent: EP1362856, 2003, A1. Location in patent: Page/Page column 159
[5] Journal of Heterocyclic Chemistry, 2006, vol. 43, # 5, p. 1195 - 1204

6-AMINOPHTHALIDE Preparation Products And Raw materials

Raw materials

6-Nitrophthalide Methanol Tetrahydrofuran Hydrogen

Preparation Products

5-CHLORO-2-FORMYL-BENZOIC ACID 6-Cyanophthalide 6-IODO-3 H-ISOBENZOFURAN-1-ONE

6-AMINOPHTHALIDE Suppliers

Global( 126)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5228	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3992	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co,.LTD	58
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 6-AMINOPHTHALIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	6-AMINOPHTHALIDE 57319-65-0	$10.00	1KG	99.8%	100000kgs	Hebei Chuanghai Biotechnology Co,.LTD
2025-12-24	6-AMINOPHTHALIDE 57319-65-0		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-09-12	6-Aminophthalide 57319-65-0	$950.00	1g	99 %	500 Kg	R&D Scientific Inc.

6-AMINOPHTHALIDE
57319-65-0
$10.00
99.8%
Hebei Chuanghai Biotechnology Co,.LTD

6-AMINOPHTHALIDE
57319-65-0
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

6-Aminophthalide
57319-65-0
$950.00
99 %
R&D Scientific Inc.

6-AMINOPHTHALIDE Spectrum

6-AMINOPHTHALIDE(57319-65-0)¹HNMR

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BUTTPARK 33\04-93 6-AMINO-2-BENZOFURAN-1(3H)-ONE 6-AMINO-1,3-DIHYDROISOBENZOFURAN-1-ONE 6-AMINOISOBENZOFURAN-1-ONE 6-AMINOPHTHALIDE 6-Aminophtalide 6-Aminophthalide,95% 6-Amino-1,3-dihydroisobenzofuran-1-one, 95+% 6-Aminophthalide 97% 6-AMino-1,3-dihydroisobenzofuran-1-one hydrochloride 6-amino-1,3-dihydro-2-benzofuran-1-one 1(3H)-Isobenzofuranone, 6-amino- 6-amino-3H-2-benzofuran-1-one RMA-283 6-Aminophthalide 6-Aminophthalide 6-Aminophthalide 97% 6-Aminoisobenzofuran-1(3H)-one 57319-65-0 Miscellaneous Amines Furan&Benzofuran Fused Ring Systems