2-Methylthiazole-4-carboxamide
- CAS No.
- 31825-95-3
- Chemical Name:
- 2-Methylthiazole-4-carboxamide
- Synonyms
- 2-Methyl-4-thiazolecarboxamide;4-THIAZOLECARBOXAMIDE, 2-METHYL-;2-Methyl-1,3-oxazole-4-carboamide
- CBNumber:
- CB3776092
- Molecular Formula:
- C5H6N2OS
- Molecular Weight:
- 142.18
- MDL Number:
- MFCD00221183
- MOL File:
- 31825-95-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Note | Harmful |
| HS Code | 2934100090 |
2-Methylthiazole-4-carboxamide price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR29665 | 2-Methyl-1,3-thiazole-4-carboxamide ≥95% | 31825-95-3 | 250mg | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR29665 | 2-Methyl-1,3-thiazole-4-carboxamide ≥95% | 31825-95-3 | 1g | $120 | 2026-06-04 | Buy |
| Activate Scientific | AS110650 | 2-Methylthiazole-4-carboxamide 98% | 31825-95-3 | 1g | $205 | 2026-06-04 | Buy |
| Activate Scientific | AS110650 | 2-Methylthiazole-4-carboxamide 98% | 31825-95-3 | 5g | $622 | 2026-06-04 | Buy |
| Matrix Scientific | 132190 | 2-Methylthiazole-4-carboxamide | 31825-95-3 | 1.00g | $681 | 2026-05-18 | Buy |
2-Methylthiazole-4-carboxamide Chemical Properties, Uses, Production
Uses
2-Methylthiazole-4-carboxamide is a useful reactant for the synthesis of bisthiazole-based histone deacetylase inhibitors.
Synthesis
6436-59-5
31825-95-3
Step 1. Synthesis of 2-methylthiazole-4-carboxamide (Compound 2A) Ethyl 2-methylthiazole-4-carboxylate (Compound 1, 0.8 g, 4.68 mmol) was mixed with an ethanol solution of ammonia (NH3/EtOH, 10 mL) and the reaction was stirred at 60 °C for 6 days. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate=1:1) to afford 2-methylthiazole-4-carboxamide (Compound 2, 0.44 g, 77% yield) as a white solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[2] Patent: WO2011/106414, 2011, A1. Location in patent: Page/Page column 83
[3] Journal of the Chemical Society, 1946, p. 91
[4] Journal of Organic Chemistry, 2009, vol. 74, # 15, p. 5750 - 5753
[5] Journal of the American Chemical Society, 2011, vol. 133, # 15, p. 5900 - 5904
2-Methylthiazole-4-carboxamide Preparation Products And Raw materials
2-Methylthiazole-4-carboxamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4563 | 58 |
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| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Chengdu Forest Science and Technology Development Co,. Ltd | 028-87925786 18010564218 | vendi@cdforestchem.com | China | 1992 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Xinyi Kaiwu Chemical Technology Co., Ltd. | 0516-0516-88997009 18651776937 | 4164357@qq.com | China | 3204 | 58 |
