alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
- CAS No.
- 24155-42-8
- Chemical Name:
- alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
- Synonyms
- 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANOL;Imidazole alcohol;IMIDAZOLE ETHANOL;1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol;t824;r14821;MIC III;SQ-13283;1-[2-(2,4-DichL;)-2-hydroxyethyL
- CBNumber:
- CB3780543
- Molecular Formula:
- C11H10Cl2N2O
- Molecular Weight:
- 257.12
- MDL Number:
- MFCD00044708
- MOL File:
- 24155-42-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Enilconazole impurity E European Pharmacopoeia (EP) Reference Standard | Y0000137 | 20 mg | $254 |
| Econazole Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | PHR2231 | 100MG | $594 |
| 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol AldrichCPR | CDS003858 | 250mg | $77.9 |
| Miconazole impurity A British Pharmacopoeia (BP) Reference Standard | BP884 | 25MG | $251 |
| Enilconazole impurity E | 1231830 | 15mg | $1390 |
| More product size | |||
| Melting point | 134-138 °C |
|---|---|
| Boiling point | 468.5±45.0 °C(Predicted) |
| Density | 1.4133 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 12.25±0.20(Predicted) |
| form | solid |
| color | White to Pale Yellow |
| Water Solubility | 1300 g/L (20 ºC) |
| InChI | 1S/C11H10Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15/h1-5,7,11,16H,6H2 |
| InChIKey | UKVLTPAGJIYSGN-UHFFFAOYSA-N |
| SMILES | OC(Cn1ccnc1)c2ccc(Cl)cc2Cl |
| LogP | 2.31 at 20℃ |
| CAS DataBase Reference | 24155-42-8(CAS DataBase Reference) |
| FDA UNII | CP4AM80T68 |
| EPA Substance Registry System | 1H-Imidazole-1-ethanol, ?-(2,4-dichlorophenyl)- (24155-42-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 38-28B-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI5485000 | |||||||||
| HS Code | 2933290000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000137 | Enilconazole impurity E European Pharmacopoeia (EP) Reference Standard | 24155-42-8 | 20 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2231 | Econazole Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 24155-42-8 | 100MG | $594 | 2026-04-30 | Buy |
| Sigma-Aldrich | CDS003858 | 1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol AldrichCPR | 24155-42-8 | 250mg | $77.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP884 | Miconazole impurity A British Pharmacopoeia (BP) Reference Standard | 24155-42-8 | 25MG | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1231830 | Enilconazole impurity E | 24155-42-8 | 15mg | $1390 | 2026-04-30 | Buy |
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Chemical Properties,Uses,Production
Chemical Properties
cream-coloured to beige powder
Uses
Intermediate in the preparation of Miconazole. An impurity in the synthesis of Fenticonazole. An impurity in the synthesis of Ketoconazole.
Uses
Intermediate in the preparation of Miconazole.An impurity in the synthesis of Fenticonazole.An impurity in the synthesis of Ketoconazole.Econazole EP Impurity A.
Application
In the pharmaceutical field, alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol is an important precursor for the synthesis of various imidazole antifungal drugs (such as econazole and miconazole), which are widely used to treat fungal infections. Furthermore, it is an intermediate in the production of agricultural fungicides (such as imidazoles), which are used in agriculture to control various plant diseases, such as powdery mildew and black rot, thereby increasing crop yields.
Flammability and Explosibility
Not classified
Synthesis
46503-52-0
24155-42-8
General procedure for the synthesis of alpha-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol from 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone: In a 1000 mL three-necked flask equipped with a stirrer, a thermometer, and a dropping funnel, add 102 g of 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone (0.4 mol) and 300 mL of methanol. Potassium borohydride was added in batches and slowly heated to reflux. After completion of the reaction, stirring was continued for 1 h and the progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent was ethyl acetate: methanol = 10:1, v/v). At the end of the reaction, methanol was recovered by distillation under reduced pressure. The concentrate was adjusted to pH 4-5 with 5% hydrochloric acid solution and subsequently diafiltrated. The filtrate was adjusted pH to 7-8 with 5% sodium bicarbonate solution, when a white solid precipitated. The solid was collected by filtration, washed with water, dried and recrystallized to give 93.1 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol in 90.5% yield with a melting point of 134-135 °C.
References
[1] Patent: CN102180835, 2016, B. Location in patent: Paragraph 0015; 0016
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674
[3] Polyhedron, 2013, vol. 52, p. 106 - 114
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294
[5] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 162 - 175
alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
| Wuhan Biocar Pharmacy CO.,Ltd. | +86-86-13343427080 +8613343427080 | wxxxxxxj@gmail.com | China | 495 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 923 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
View Lastest Price from alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-01 | alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-05-21 | alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
|
$12.00 | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-03-20 | alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
- $12.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
