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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol structure

CAS No.: 24155-42-8

Chemical Name:: alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol

Synonyms: 1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHANOL;Imidazole alcohol;IMIDAZOLE ETHANOL;1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol;t824;r14821;MIC III;SQ-13283;1-[2-(2,4-DichL;)-2-hydroxyethyL

CBNumber:: CB3780543

Molecular Formula:: C11H10Cl2N2O

Molecular Weight:: 257.12

MDL Number:: MFCD00044708

MOL File:: 24155-42-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:01:26

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alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Properties

Melting point	134-138 °C
Boiling point	468.5±45.0 °C(Predicted)
Density	1.4133 (rough estimate)
vapor pressure	0Pa at 20℃
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	12.25±0.20(Predicted)
form	solid
color	White to Pale Yellow
Water Solubility	1300 g/L (20 ºC)
InChI	1S/C11H10Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15/h1-5,7,11,16H,6H2
InChIKey	UKVLTPAGJIYSGN-UHFFFAOYSA-N
SMILES	OC(Cn1ccnc1)c2ccc(Cl)cc2Cl
LogP	2.31 at 20℃
CAS DataBase Reference	24155-42-8(CAS DataBase Reference)
FDA UNII	CP4AM80T68
EPA Substance Registry System	1H-Imidazole-1-ethanol, ?-(2,4-dichlorophenyl)- (24155-42-8)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H319

Precautionary statements

P301+P312+P330-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38

Safety Statements

38-28B-36-26

WGK Germany

RTECS

NI5485000

HS Code

2933290000

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
2		0

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0000137	Enilconazole impurity E European Pharmacopoeia (EP) Reference Standard	24155-42-8	20 mg	$254	2026-04-30	Buy
Sigma-Aldrich	PHR2231	Econazole Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material	24155-42-8	100MG	$594	2026-04-30	Buy
Sigma-Aldrich	CDS003858	1-(2,4-dichloro-phenyl)-2-imidazol-1-yl-ethanol AldrichCPR	24155-42-8	250mg	$77.9	2026-04-30	Buy
Sigma-Aldrich	BP884	Miconazole impurity A British Pharmacopoeia (BP) Reference Standard	24155-42-8	25MG	$251	2026-04-30	Buy
Sigma-Aldrich	1231830	Enilconazole impurity E	24155-42-8	15mg	$1390	2026-04-30	Buy

Product number	Packaging	Price	Buy
Y0000137	20 mg	$254	Buy
PHR2231	100MG	$594	Buy
CDS003858	250mg	$77.9	Buy
BP884	25MG	$251	Buy
1231830	15mg	$1390	Buy

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Chemical Properties, Uses, Production

Chemical Properties

cream-coloured to beige powder

Uses

Intermediate in the preparation of Miconazole. An impurity in the synthesis of Fenticonazole. An impurity in the synthesis of Ketoconazole.

Uses

Intermediate in the preparation of Miconazole.An impurity in the synthesis of Fenticonazole.An impurity in the synthesis of Ketoconazole.Econazole EP Impurity A.

Application

In the pharmaceutical field, alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol is an important precursor for the synthesis of various imidazole antifungal drugs (such as econazole and miconazole), which are widely used to treat fungal infections. Furthermore, it is an intermediate in the production of agricultural fungicides (such as imidazoles), which are used in agriculture to control various plant diseases, such as powdery mildew and black rot, thereby increasing crop yields.

Flammability and Explosibility

Not classified

Synthesis

1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOLE-1-YL) ETHANONE

46503-52-0

24155-42-8

General procedure for the synthesis of alpha-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol from 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone: In a 1000 mL three-necked flask equipped with a stirrer, a thermometer, and a dropping funnel, add 102 g of 2'-(1H-imidazol-1-yl)-2,4-dichloroacetophenone (0.4 mol) and 300 mL of methanol. Potassium borohydride was added in batches and slowly heated to reflux. After completion of the reaction, stirring was continued for 1 h and the progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent was ethyl acetate: methanol = 10:1, v/v). At the end of the reaction, methanol was recovered by distillation under reduced pressure. The concentrate was adjusted to pH 4-5 with 5% hydrochloric acid solution and subsequently diafiltrated. The filtrate was adjusted pH to 7-8 with 5% sodium bicarbonate solution, when a white solid precipitated. The solid was collected by filtration, washed with water, dried and recrystallized to give 93.1 g of 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol in 90.5% yield with a melting point of 134-135 °C.

References

[1] Patent: CN102180835, 2016, B. Location in patent: Paragraph 0015; 0016
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 1665 - 1674
[3] Polyhedron, 2013, vol. 52, p. 106 - 114
[4] Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4288 - 4294
[5] Medicinal Chemistry Research, 1999, vol. 9, # 3, p. 162 - 175

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol synthesis

Synthesis of alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol from 1-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanone

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Preparation Products And Raw materials

Raw materials

1-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanone 1-Butanaminium, N,N,N-tributyl-, salt with 1H-imidazole (1:1) Imidazole alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol α-(Bromomethyl)-2,4-dichlorobenzenemethanol

(2,4-dichlorophenyl)oxirane Potassium borohydride Methanol

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Preparation Products

Imazalil 1-(2-(2-(4-Chlorophenoxy)ethoxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imida zole nitrate Isoconazole

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Suppliers

Global Suppliers ( 465)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Ruibowen New Material Technology Co., Ltd	15064961989	420700630@qq.com	China	274	58
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	822	55
Klong Industrial Co., Ltd	519-68231162 13961227312	info@klongchem.com	China	166	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Shandong Ruibowen New Material Technology Co., Ltd	58
BTC Pharmaceutical CO. Ltd	55
Klong Industrial Co., Ltd	58
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59

View Latest Price from alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 24155-42-8			0.99		RongNa Biotechnology Co.,Ltd
2026-09-18	alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 24155-42-8	$12.00	1KG	99%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-09-02	alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 24155-42-8	$1.10-34.00	1kg	99%		Henan Fengda Chemical Co., Ltd

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
0.99
RongNa Biotechnology Co.,Ltd

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
$12.00
99%
Jinan Finer Chemical Co., Ltd

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
24155-42-8
$1.10-34.00
99%
Henan Fengda Chemical Co., Ltd

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol Spectrum

alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol(24155-42-8)MS alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol(24155-42-8)IR1

24155-42-8 (alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol) Related Search:

Monoethanolamine Imidazole Diethanolamine Dichlorodiphenylsilane Levamisole

Econazole Isoconazole Dichloroethane Ethyl acetate Diethylstilbestrol

Dichloromethylphenylsilane Miconazole nitrate 2,4-Dichloro-β-[(2,6-dichlorophenyl)methoxy]benzeneethanamine Ethanol alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol

1-(2,4-Dichlorophenyl)-2-(1H-imidazole-1-yl) ethanone Miconazole Impurity Miconazole IMpurity I

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-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol 1-(2,4-DICHLOROPHENYL)-2-IMIDAZOL-1-YL ETHANOL 1H-IMIDAZOLE-1-ETHANOL, ALPHA-(2,4-DICHLOROPHENYL)- ALPHA-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOL ALPHA-(2,4-DICHLOROPHENYL)-2-1H-IMIDAZOLE-1-ETHANOL ALPHA-(2,4-DICHLORO PHENYL)-B-(IMIDAZOLE-YL)ETHANOL 1-[2-(2,4-DichL 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]-1H-imidazole, 2,4-Dichloro-alpha-[(1H-imidazol-1-yl)methyl]benzyl alcohol 1-(2,4-dichlorophenyl)-2-(1H-iMidazol-1-yl)-ethano 1-(2,4-dichloro-phenyl)-2(Midazole-l-)-ethand Isoconazole IMpurity A 2,4-dichloro-alpha-(1-imidazolylmethyl)-benzylalcoho alpha-(2,4-dichlorophenyl)-imidazole-1-ethano n-(beta-(2,4-dichlorophenyl)-beta-hydroxyethyl)imidazole r14821 t824 α-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol ,99% (1RS)-1-(2,4-Dichlorophenyl)-2-(-1H-imidazol-1-yl)ethanol Isoconazole Nitrate EP Impurity A Fenticonazole Nitrate impurity A (EP) -E Fenticonazole Nitrate impurity A (EP) Isoconazole EP impurity B Imidazole alcohol Econazole Impurity 1(Econazole EP Impurity A) Miconazole Impurity 1(Miconazole EP Impurity A) Fenticonazole Nitrate EP Impurity A Econazole EP Impurity A Miconazole EP Impurity A Miconazole Nitrate EP Impurity A 1-(2,4-Dichlorphenyl)-2-1-Imidazolyl)-Ethanol 1-(2,4-Dichlorophenyl)-2-((1H)-imidazol-1-yl)-ethane alpha-(2,4-Dichlorophenyl)-1H- 2-(2,4-dichlorobenzene)-imidazole-1-ethanol ALPHA- (2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-ETHANOL Imidazole-1-ethanol alpha-(2,4-dichlorophenyl) 1-(2-(2,4-dichlorophenyl)-2-hydroxyethyl)-1H-imidazole 2,4-dichloro-alpha-(1-imidazolylmethyl)-benzyl alcohol alpha-(2,4-dichlorophenyl)-imidazole-1-ethanol 1H-IMIDAZOLE-1-ETHANOL,A-(2,4-DICHLOROPHENYL)- 1,2(2,4-Dichlorophenyl)-1H-(N-Imidazolyl)Ethanol A-(2,4-DICHLOROPHENYL)-1H-IMIDAZOLE-1-ETHANOLMICONAZOLE 1-[2-(2,4-Dichlorophenyl)-2-hydroxyethyl]imidazole 1-(β-Hydroxy-2,4-dichlorophenethyl)-1H-imidazole SQ-13283 alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol,98% rac-1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol Benzyl alcohol, 2,4-dichloro-alpha-(1-imidazolylmethyl) （2，4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol Fenticonazole EP Impurity A Isoconazole EP Impurity A 1-(2,4-Dichlorophenyl)-2-(1-imidazolyl)ethanol> Sertaconazole nitrate EP Impurity A (1RS)-1-(2,4-Dichlorophenyl)-2-(1H- Enilconazole impurity E CRS Tioconazole EP Impurity D Enilconazole EP Impurity E 1H-Imidazole-1-ethanol, α-(2,4-dichlorophenyl)-