4-Amino-2-chloroquinoline
- CAS No.
- 80947-25-7
- Chemical Name:
- 4-Amino-2-chloroquinoline
- Synonyms
- 2-Chloroquinolin-4-amine;2-Chloro-4-quinolinamine;4-Amino-2-chloroquinoline;4-Quinolinamine,2-chloro-;(2-Chloroquinolin-4-yl)amine
- CBNumber:
- CB3789061
- Molecular Formula:
- C9H7ClN2
- Molecular Weight:
- 178.62
- MDL Number:
- MFCD08705643
- MOL File:
- 80947-25-7.mol
- MSDS File:
- SDS
| Melting point | 250℃ |
|---|---|
| Boiling point | 366℃ |
| Density | 1.363 |
| Flash point | 175℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 4.24±0.50(Predicted) |
| Appearance | White to light brown Solid |
| InChI | InChI=1S/C9H7ClN2/c10-9-5-7(11)6-3-1-2-4-8(6)12-9/h1-5H,(H2,11,12) |
| InChIKey | QVCRGJALYOLXDC-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2)C(N)=CC=1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H302-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| HS Code | 2933499090 |
4-Amino-2-chloroquinoline price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR925609 | 2-Chloroquinolin-4-amine >95% | 80947-25-7 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR925609 | 2-Chloroquinolin-4-amine >95% | 80947-25-7 | 1g | $43 | 2026-06-04 | Buy |
| Apolloscientific | OR925609 | 2-Chloroquinolin-4-amine >95% | 80947-25-7 | 5g | $179 | 2026-06-04 | Buy |
| Apolloscientific | OR925609 | 2-Chloroquinolin-4-amine >95% | 80947-25-7 | 25g | $780 | 2026-06-04 | Buy |
| Apolloscientific | OR925609 | 2-Chloroquinolin-4-amine >95% | 80947-25-7 | 100g | $3112 | 2026-06-04 | Buy |
4-Amino-2-chloroquinoline Chemical Properties, Uses, Production
Synthesis
703-61-7
80947-25-7
The general procedure for the synthesis of 4-amino-2-chloroquinoline from 2,4-dichloroquinoline is as follows: the synthesis of compound 9 has been reported in the literature [von Btichi, J. et al. Die Tuberkulostatische Wirkung von 2-Oxy-4-amino-chinolin Derivaten. Helv. Chim. Acta. 1949, 32, 1806-1814; Wojahn, H. Untersuchungen ber den Zusammenhang von chemischer Konstitution und anasthesierender Wirkung bei 2- Alkoxy-chinolin Derivaten. Arch. Pharm. 1936, 274, 83-106]. However, in the present experiments, compound 9 was prepared by the following method. the brief procedure was as follows: compound 8 (0.35 g, 1.8 mmol) was suspended in 28-30% aqueous ammonia solution (3 mL). The reaction was carried out in a microwave reactor at 160 °C for 2.5 hours. Upon completion of the reaction, the ammonia was removed by evaporation. The product was purified by column chromatography using dichloromethane solution containing 3% methanol as eluent. Yield: 0.14 g (44%).1H NMR (CDCl3) δ 4.83 (broad single peak, 2H, NH2), 6.62 (single peak, 1H, aromatics), 7.43-7.51 (multiple peaks, 1H, aromatics), 7.63-7.73 (multiple peaks, 2H, aromatics), 7.89-7.95 (multiple peaks, 1H, aromatics).13C NMR ( 600 MHz, CDCl3) δ 103.07, 117.60, 120.08, 125.27, 129.13, 130.46, 148.26, 151.40, 151.41.
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 4, p. 926 - 931
[2] Patent: WO2010/20981, 2010, A1. Location in patent: Page/Page column 30; 2/2
[3] Journal of Photochemistry and Photobiology A: Chemistry, 2017, vol. 332, p. 72 - 86
4-Amino-2-chloroquinoline Preparation Products And Raw materials
4-Amino-2-chloroquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Baiyin Chengze Chemical Technology Co., Ltd. | +86 943-8535351 13389336721 | sales@chengzechem.com | China | 300 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai YuYuan Pharmaceutical Co., Ltd. | 13052276172 | product@yuyuanpharm.com | China | 402 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 031166536426; | master@sjzsdyn.com | China | 3491 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
