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Pirtobrutinib

Pirtobrutinib Structure
Pirtobrutinib structure
CAS No.
2101700-15-4
Chemical Name:
Pirtobrutinib
Synonyms
Pirtobrutinib;Pirtobrutinib (LOXO-305);loxo-305;LY 3527727;BTK inhibitor 16;Florfenicol Impurity 16;Pirtobrutinib, 10 mM in DMSO;LOXO-305，LY 3527727，Pirtobrutinib;(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-
CBNumber:
CB38153637
Molecular Formula:
C22H21F4N5O3
Molecular Weight:
479.43
MDL Number:
MFCD34179491
MOL File:
2101700-15-4.mol
Last updated:2025-05-14 08:33:34
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Pirtobrutinib Properties

Boiling point 619.2±55.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. 4°C, stored under nitrogen
solubility DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
form A solid
pka 13.32±0.46(Predicted)
color White to yellow
FDA UNII JNA39I7ZVB

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H373-H360
Precautionary statements  P260-P314-P501

Pirtobrutinib Chemical Properties,Uses,Production

Description

Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.

Uses

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM[1].

References

[1] Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644.

Pirtobrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

Pirtobrutinib Suppliers

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Joiny Pharmaceutical Co.,LTD 		+86-13681955282 +86-13681955282 gyd@joiny-pharma.com China 254 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 19919 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Henan Alfa Chemical Co., Ltd 		+8615838112936 alfa10@alfachem.cn China 13232 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
Supplier Advantage
Shanghai Joiny Pharmaceutical Co.,LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Henan Alfa Chemical Co., Ltd 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58

View Lastest Price from Pirtobrutinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pirtobrutinib pictures 2025-05-13 Pirtobrutinib
2101700-15-4
 US $31.00-128.00 / mg 99.94% 10g TargetMol Chemicals Inc.
Pirtobrutinib pictures 2025-04-28 Pirtobrutinib
2101700-15-4
 US $0.00 / kg 1kg 99% 200kg Shanghai Joiny Pharmaceutical Co.,LTD
  • Pirtobrutinib pictures
  • Pirtobrutinib
    2101700-15-4
  • US $31.00-128.00 / mg
  • 99.94%
  • TargetMol Chemicals Inc.
  • Pirtobrutinib pictures
  • Pirtobrutinib
    2101700-15-4
  • US $0.00 / kg
  • 99%
  • Shanghai Joiny Pharmaceutical Co.,LTD

Pirtobrutinib Spectrum

LOXO-305(2101700-15-4)1HNMR
1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]- (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide Pirtobrutinib Pirtobrutinib (LOXO-305) LY 3527727 loxo-305 (S)-5-Amino-3-{4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-phenyl}-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-pyrazole-4-carboxylic acid amide LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation Florfenicol Impurity 16 LOXO-305，LY 3527727，Pirtobrutinib BTK inhibitor 16 [2,4,6-tribromo-thiophenol, Benzenethiol-2,4,6-tribromide, benzenethiol 2,4,6-tribromine, 2.4.6-Tribrom-phenylmercaptan, 2,4,6-tribromo benzenethiol, 2.4.6-Tribrom-1-mercapto-benzol, 2,4,6-Tribrom-thi Pirtobrutinib, 10 mM in DMSO 2101700-15-4 api Pirtobrutinib