PF-04671536
- CAS No.
- 1305116-69-1
- Chemical Name:
- PF-04671536
- Synonyms
- PF-04671536;PF-04671536 >=98% (HPLC);3H-1,2,3-Triazolo[4,5-d]pyrimidin-7-amine, 5-methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-
- CBNumber:
- CB38378696
- Molecular Formula:
- C14H18N8OS
- Molecular Weight:
- 346.41
- MDL Number:
- MOL File:
- 1305116-69-1.mol
PF-04671536 Chemical Properties,Uses,Production
Uses
PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use[1].
Biological Activity
PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.
References
[1] Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
PF-04671536 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-04671536 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19903 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20672 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Merck KGaA | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 58 |
View Lastest Price from PF-04671536 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | PF-04671536
1305116-69-1
|
US $2500.00-1980.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- PF-04671536
1305116-69-1
- US $2500.00-1980.00 / mg
- TargetMol Chemicals Inc.