Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Structure
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride structure
CAS No.
111974-74-4
Chemical Name:
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Synonyms
Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QUETIAPINE RC B;Norquetiapine.HCl;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride
CBNumber:
CB3854879
Molecular Formula:
C17H18ClN3S
Molecular Weight:
331.86
MDL Number:
MFCD08703302
MOL File:
111974-74-4.mol
Last updated:2026-01-13 11:18:54
Product description Number Pack Size Price
N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol) KIT1365 10x1ml $145
N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride D288740 5g $155
QuetiapineEPImpurityB2HCl J11616 25mg $39
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% 090783 1g $114
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% 090783 5g $303
More product size
Request For Quotation

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Properties

Melting point 180-184°C
storage temp. Inert atmosphere,2-8°C
solubility Soluble in DMSO, Methanol, Distilled Water
form solid
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
Major Application pharmaceutical
InChI InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference 111974-74-4(CAS DataBase Reference)
FDA UNII 7VJ4TC63IL
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Warning
Hazard statements  H413
Precautionary statements  P501-P273
WGK Germany  WGK 3
HS Code  2934990002
Storage Class 11 - Combustible Solids

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC KIT1365 N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol) 111974-74-4 10x1ml $145 2021-12-16 Buy
TRC D288740 N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride 111974-74-4 5g $155 2021-12-16 Buy
AK Scientific J11616 QuetiapineEPImpurityB2HCl 111974-74-4 25mg $39 2021-12-16 Buy
Matrix Scientific 090783 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% 111974-74-4 1g $114 2021-12-16 Buy
Matrix Scientific 090783 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride 95+% 111974-74-4 5g $303 2021-12-16 Buy
Product number Packaging Price Buy
KIT1365 10x1ml $145 Buy
D288740 5g $155 Buy
J11616 25mg $39 Buy
090783 1g $114 Buy
090783 5g $303 Buy

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Uses,Production

Description

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4

Chemical Properties

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid

Uses

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic

Uses

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.

References

[1] A CARLO ALTAMURA. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.[J]. Clinical Drug Investigation, 2012, 32 3: 213-219. DOI:10.2165/11597330-000000000-00000
[2] FRANCISCO LÓPEZ-MUÑOZ  Cecilio A. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders.[J]. Frontiers in Psychiatry, 2013: 102. DOI:10.3389/fpsyt.2013.00102
[3] BARBARA DI BENEDETTO . N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant[J]. Neuropharmacology, 2012, 62 1: Pages 209-216. DOI:10.1016/j.neuropharm.2011.07.001
[4] CARL BJÖRKHOLM . Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine[J]. European Neuropsychopharmacology, 2013, 23 7: Pages 709-720. DOI:10.1016/j.euroneuro.2012.05.012

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Suppliers

Global( 267)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		+86-0519-8359-8696 +8618018249389 sales@anikare.com China 9951 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21599 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29833 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Supplier Advantage
Changzhou AniKare Pharmatech Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58

View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures 2025-04-04 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride pictures 2021-12-22 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride
111974-74-4
 US $1.50 / g 1KG 99% 5ton/Month Qiuxian Baitai New Material Co., LTD
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures 2019-07-06 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
 US $1.00 / KG 1KG 99% Customized Career Henan Chemical Co

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Spectrum

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride(111974-74-4)1HNMR

111974-74-4(11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride)Related Search:

Quetiapine Carboxylate Impurity 2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol dihydrochloride Quetiapine Dimer Impurity 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate Quetiapine Hydroxy Impurity
Quetiapine N-Oxide 1,2-Bis[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetaMide
2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethanol FuMarate Ethyl Quetiapine Fumarate Salt Quetiapine EP Impurity N DiHCl dibenzo[b,f][1,4]thiazepin-11-amine Quetiapine EP Impurity W
Quetiapine Sulfone Quetiapine EP Impurity N Quetiapine EP Impurity C

1of4

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP, 11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2) 11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride 11-Piperazinodibenzo-[b,f][1,4]-thiazepin N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl Quetiapine IMpurity A (DBTP Metabolite) Quetiapine DBTP Metabolite 11-PIPERAZYNIL-DIBENZO[B,F][1,4] THIAZEP Quetiapine EP Impurity B DiHCl Quetiapine Impurity 28(Quetiapine EP Impurity B) 11-(1-Piperazinyl)-dibenzo[b 4]thiazepine dihydrochloride Quetiapine Related CoMpound B 11-piperazinyl-dibenzo d,f 1,4 thiazepine dihydrochloride N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1.0 Mg/ML in Methanol) Quetiapine Impurity B DiHCl Quetiapine EP Impurity B 11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride 11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP) 11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride 11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl 1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE 11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL 11-(Piperazin-1-yl)dibenzo[b,f][1,4 Norquetiapine dihydrochloride 11-Piperazinodibenzo[b,f][1,4]thiazepine DiHCl Norquetiapine dihydrochloride salt 11-Piperazynil-dibenzo[b,f][1,4]thiazepine dihydrochloride (DBTP) Quetiapine Impurity-B/RC-2 Quetiapine Fumarate EP Impurity B Quetiapine EP Impurity B/ Quetiapine Related Compound B (Quetiapine DBTP Metabolite) 11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine hydrochloride 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine DihydrochlorideQ: What is N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the CAS Number of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the storage condition of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What are the applications of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride 111974-74-4 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine（Quetiapine EP Impurity B) Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737) Quetiapine Impurity B (EP) DiHCl Quetiapine Fumarate Impurity B as Dihydrochloride Quetiapine Related Compound B as Dihydrochloride Quetiapine Fumarate EP Impurity B as Dihydrochloride Quetiapine USP Related Compound B as Dihydrochloride QuetiapineEPImpurityB2HCl 11-(1-piperazinyl)-Dibenzo[b,f][1,4]thiazepine hydrochloride (1:2) 11-Piperazinodibenzo-[b,f][1,4]-thiazepin dihydrochloride Quetiapine EP Impurity B Dihydrochloride