11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Structure](CAS/GIF/111974-74-4.gif)
- CAS No.
- 111974-74-4
- Chemical Name:
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- Synonyms
- Quetiapine EP Impurity B;Quetiapine Related CoMpound B;Norquetiapine dihydrochloride salt;11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride;QUETIAPINE RC B;Norquetiapine.HCl;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl
- CBNumber:
- CB3854879
- Molecular Formula:
- C17H18ClN3S
- Molecular Weight:
- 331.86
- MDL Number:
- MFCD08703302
- MOL File:
- 111974-74-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1 mg/mL in Methanol) | TRC-KIT1365-10X1ML | 10x1mL | $186 |
| 11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL 97% | 26951 | 1G | $23 |
| 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | FP32447 | 25g | $172 |
| 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | FP32447 | 50g | $275 |
| 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | FP32447 | 100g | $413 |
| More product size | |||
| Melting point | 180-184°C |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO, Methanol, Distilled Water |
| form | solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. |
| Major Application | pharmaceutical |
| InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H |
| InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N |
| SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl |
| CAS DataBase Reference | 111974-74-4(CAS DataBase Reference) |
| FDA UNII | 7VJ4TC63IL |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-KIT1365-10X1ML | N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1 mg/mL in Methanol) | 111974-74-4 | 10x1mL | $186 | 2026-06-03 | Buy |
| AstaTech | 26951 | 11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL 97% | 111974-74-4 | 1G | $23 | 2026-04-30 | Buy |
| Biosynth | FP32447 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | 111974-74-4 | 25g | $172 | 2026-06-04 | Buy |
| Biosynth | FP32447 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | 111974-74-4 | 50g | $275 | 2026-06-04 | Buy |
| Biosynth | FP32447 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | 111974-74-4 | 100g | $413 | 2026-06-04 | Buy |
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Uses,Production
Description
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1 Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2 Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical Properties
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Uses
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Uses
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References
[1] A CARLO ALTAMURA. Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study.[J]. Clinical Drug Investigation, 2012, 32 3: 213-219. DOI:10.2165/11597330-000000000-00000
[2] FRANCISCO LÓPEZ-MUÑOZ Cecilio A. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders.[J]. Frontiers in Psychiatry, 2013: 102. DOI:10.3389/fpsyt.2013.00102
[3] BARBARA DI BENEDETTO . N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: A putative cellular mechanism for quetiapine as antidepressant[J]. Neuropharmacology, 2012, 62 1: Pages 209-216. DOI:10.1016/j.neuropharm.2011.07.001
[4] CARL BJÖRKHOLM . Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine[J]. European Neuropsychopharmacology, 2013, 23 7: Pages 709-720. DOI:10.1016/j.euroneuro.2012.05.012
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9969 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9542 | 58 |
View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures](/ProductImageEN/2022-09/Small/ca453e12-9f17-4bb4-8d9a-c7b4514eefda.png) |
2025-04-04 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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![11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride pictures](/ProductImageEN/2021-12/Small/b95beabd-6ef3-4ebb-b47b-f00fa974a7cd.jpg) |
2021-12-22 | 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride
111974-74-4
|
$1.50 | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride pictures](https://img.chemicalbook.com/ProductImageEN/2018-8/Small/8c16ec46-68a1-4aad-acd4-ade33bd9cd25.jpg) |
2019-07-06 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride
111974-74-4
- $1.50
- 99%
- Qiuxian Baitai New Material Co., LTD
-
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
111974-74-4
- $1.00
- 99%
- Career Henan Chemical Co
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