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ChemicalBook >> CAS DataBase List >>1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Structure
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine structure
CAS No.
120014-07-5
Chemical Name:
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
Synonyms
Donepezil-013;Donepezil-013-Z;Donepezil imp B;Dehydro Donepezi;Dehydro Donepezil;Donepezil USP RC A;Donepezil Impurity O;Donepezil Impurity 17;Donepezil related compound;1-Benzyl-4-(5,6-dimethoxy-1-ox
CBNumber:
CB3854945
Molecular Formula:
C24H27NO3
Molecular Weight:
377.48
MDL Number:
MFCD08693144
MOL File:
120014-07-5.mol
MSDS File:
SDS
Last updated:2025-07-24 18:11:54
Product description Number Pack Size Price
Donepezilrelatedcompound(E/Zmixture) J11663 100mg $49
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 97% 036506 1g $55
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine IB18353 100mg $60
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine IB18353 250mg $100
2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97% OR61173 5g $137
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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Properties

Melting point 176-178°C
Boiling point 542.8±50.0 °C(Predicted)
Density 1.209±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 8.03±0.10(Predicted)
Appearance White to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
HS Code  2933399990

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific J11663 Donepezilrelatedcompound(E/Zmixture) 120014-07-5 100mg $49 2021-12-16 Buy
Oakwood 036506 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 97% 120014-07-5 1g $55 2021-12-16 Buy
Biosynth Carbosynth IB18353 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine 120014-07-5 100mg $60 2021-12-16 Buy
Biosynth Carbosynth IB18353 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine 120014-07-5 250mg $100 2021-12-16 Buy
Apolloscientific OR61173 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97% 120014-07-5 5g $137 2021-12-16 Buy
Product number Packaging Price Buy
J11663 100mg $49 Buy
036506 1g $55 Buy
IB18353 100mg $60 Buy
IB18353 250mg $100 Buy
OR61173 5g $137 Buy

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Chemical Properties,Uses,Production

Synthesis

A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert atmosphere at room temperature. Slowly add NaOH flakes (12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The mixture was stirred at room temperature for 3 h and progress of the reaction was monitored by TLC (hexane:ethyl acetate; 1:1). Once the reaction is complete, the solid formed was filtered, washed with 5 % acetic acid and then with methanol and dried. The obtained solid (34 g) was taken into a round bottom flask and refluxed with DMF (50 mL). Gradually cooled to room temperature and stirred for 2 h, filtered the solid formed, wash with chilled methanol to afford a pale yellow crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.

Uses

An impurity of Donepezil; an intermediate as an anti-Alzheimer agent.

Uses

An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent.

References

[1] Patent: US2009/253746, 2009, A1. Location in patent: Page/Page column 3
[2] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 11-12
[3] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 10
[4] Patent: EP1911745, 2008, A1. Location in patent: Page/Page column 14
[5] Organic Process Research and Development, 2008, vol. 12, # 4, p. 731 - 735

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Preparation Products And Raw materials

Raw materials

N-Benzylpiperidine-4-carboxaldehyde 5,6-Dimethoxy-1-indanone 3-CHLORO-1-(3,4-DIMETHOXYPHENYL)PROPAN-1-ONE Toluene Water
Potassium hydroxide

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Preparation Products

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
Supplier Advantage
Standardpharm Co. Ltd. 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
sgtlifesciences pvt ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
PT CHEM GROUP LIMITED 		58

View Lastest Price from 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine pictures 2020-01-03 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
120014-07-5
 US $1.00 / KG 1KG 99% 10000KGS Career Henan Chemical Co

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Spectrum

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine(120014-07-5)1HNMR

120014-07-5(1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine)Related Search:

2,6-Dimethoxybenzaldehyde Dimethyldimethoxysilane Diphenyldimethoxysilane Benzyl benzoate Benzyl isocyanate
Benzyl chloride N,N-Dimethylbenzylamine Haloperidol 1,1-Dimethoxyethane Benzyl nicotinate
Benzyl alcohol Benzyltriethylammonium chloride 5,6-Dimethoxy-1-indanone Dimethoxymethane Donepezil
XWAIAVWHZJNZQQ-RPXFAUAJSA-N 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 5-O-Desmethyl Donepezil

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2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97% 1-Benzyl-4-(5,6-dimethoxy-1-ox 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2- 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine 2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one Dehydro Donepezil (Donepezil Impurity) 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one 1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine (Donepezil IMpurity) 1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet Dehydro Donepezi Donepezil USP RC A 1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one Donepezil related coMpound (E/Z Mixture) 1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]- (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one Dehydro Donepezil Donepezil-013 Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Donepezil related compound 1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one Donepezil Impurity O Donepezil-013-Z Donepezil Impurity 17 2-[(1-Benzylpiperidin-4-yl)methylen 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine DISCONTINUED. Please see D229775 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi... Donepezil Dehydro Impurity (E/Z mixture) 2-[(1-Benzylpiperidin-4-yl)methylene]-2,3-dihydro-5,6-dimethoxyinden-1-one (E)-1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (Z)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one Donepezil imp B 120014-07-5 C24H27NO3 Aromatics Heterocycles Intermediates Intermediates & Fine Chemicals Pharmaceuticals