ChemicalBook >> CAS DataBase List >>S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
- CAS No.
- 132335-47-8
- Chemical Name:
- S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
- Synonyms
- Duloxetine Impurity 52;Duloxetine intermediate;Duloxetine N-Methyl Oxalate;N-Methyl Duloxetine Oxalate;Duloxetine N-methyl Impurity;Duloxetine Impurity 8 Oxalate;S-(+)-N,N-Dimethyl-3-(1-naphtho;Duloxetine Impurity 8(Oxalicacid);N-Methyl Duloxetine Oxalate;Duloxetine N-Methyl (S)-Isomer Oxalate
- CBNumber:
- CB3855078
- Molecular Formula:
- C21H23NO5S
- Molecular Weight:
- 401.48
- MDL Number:
- MFCD08458302
- MOL File:
- 132335-47-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 04:21:52
| Product description | Number | Pack Size | Price |
| (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95+% | CD11294537 | 25g | $218 |
| (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95+% | CD11294537 | 100g | $653 |
| (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate ≥95% | AA0010H0 | 250mg | $10 |
| (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95% | AA0010H0 | 1g | $12 |
| (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95% | AA0010H0 | 5g | $36 |
| More product size | |||
| Melting point | >145°C (dec.) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1/C19H21NOS.C2H2O4/c1-20(2)13-12-18(19-11-6-14-22-19)21-17-10-5-8-15-7-3-4-9-16(15)17;3-1(4)2(5)6/h3-11,14,18H,12-13H2,1-2H3;(H,3,4)(H,5,6)/t18-;/s3 |
| InChIKey | GYUDMXKAVMKVPS-QAYAHANANA-N |
| SMILES | N(C)(C)CC[C@H](OC1=C2C(C=CC=C2)=CC=C1)C1SC=CC=1.C(O)(=O)C(O)=O |&1:5,r| |
| CAS DataBase Reference | 132335-47-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H228-H302-H313-H315-H318 |
| Precautionary statements | P264b-P270-P280-P302+P352-P305+P351+P338-P310-P330-P362+P364-P370+P378r-P403+P233-P501c |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| REACH Registrations | Active |
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Crysdot | CD11294537 | (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95+% | 132335-47-8 | 25g | $218 | 2026-05-26 | Buy |
| Crysdot | CD11294537 | (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95+% | 132335-47-8 | 100g | $653 | 2026-05-26 | Buy |
| aablocks | AA0010H0 | (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate ≥95% | 132335-47-8 | 250mg | $10 | 2026-05-25 | Buy |
| aablocks | AA0010H0 | (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95% | 132335-47-8 | 1g | $12 | 2026-05-25 | Buy |
| aablocks | AA0010H0 | (S)-N，N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate 95% | 132335-47-8 | 5g | $36 | 2026-05-25 | Buy |
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A duloxetine impurity.
Synthesis
321-38-0
144-62-7
132335-49-0
132335-47-8
General procedure for the synthesis of (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine oxalate from 1-fluoronaphthalene, oxalic acid and R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol: R-3-(dimethylamino)-1-(2-thiophenyl)-1-propanol (2.0 g, 0.011 mol) was was dissolved in dimethylacetamide (100 mL) and a suspension of 60% sodium hydride (463 mg, 0.012 mol) was added slowly and dropwise. The reaction mixture was heated at 70°C with stirring for 20 minutes. Subsequently, 1-fluoronaphthalene (1.27 mL, 0.012 mol) was added dropwise to the reaction system and heating was continued with stirring at 110 °C for 60 min. After completion of the reaction, the reaction mixture was diluted with water and extracted twice with ether. The organic phases were combined, washed sequentially with water and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the oily product (S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine (3.28 g, 75.6% yield).
References
[1] Patent: JP2016/172704, 2016, A. Location in patent: Paragraph 0027; 0053
Synthesis of S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate from Oxalic acid and (S)-(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate Preparation Products And Raw materials
Global( 195)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1319 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
View Lastest Price from S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory
132335-47-8
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2019-07-06 | S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-
132335-47-8
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory
132335-47-8
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-
132335-47-8
- $1.00
- 98%
- Career Henan Chemical Co
132335-47-8(S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate)Related Search:
1of4
S-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate(S)-
Duloxetine N-Methyl Oxalate
(S)-(+)-N,N-diMethyl-3-(naphthloxy)-3-(2-thienyl)
(S)-(+)-N,N-Dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thinyl)Propanamine Oxalate
(S)-(+)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-propanamine oxalate
(S)-(+)-N,N-DIMETHYL-3-NAPTHTOXY-(2-THIOPHENE) PROPYLAMINE OXALATE
Duloxetine intermediate
S-(+)-N1N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINE OXALATE
(S)-(+)-N,N-dimethyl-3-(1-naphthloxy)-3-(2-thienyl)prpylamine oxalate
S(+)-N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamineoxalate
(S)-(+)-N,N-DIMETHYL-3-(1-NAPTHTALENYLOXY)-3-(2-THIENYL)-1-PROPANAMINEHYDROCHLORIDE
S-(+)-N,N-DIMETHYL-3-(1-NAPHTHALENYLOXY)-3-(2-THIENYL)-1-PROPANEMAINEOXALATE
(S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIENYL)-PROPANAMINE OXALATE, DULOXETIN INTERMEDIATE
S-(+)-N,N-Dimethyl-3-(1-phthoxy)-3-(2-thienyl)-1-propylamine oxalate
s-(+)-n,n-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-1-propanamine oxalate
(S)-N,N-Dimethyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine ethanedioate (1:1)
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate
2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, eth
(S)-(+)-N,N-DIMETHYL-3-NAPHTHOXY-(2-THIOPHENE)-PROPYLAMINE OXALATE
S-(+)-N,N-Dimethyl-3-(1-naphtho
(S)-N,N-DiMethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanaMine Ethanedioate
N-Methyl Duloxetine Oxalate
(S)-N,N-DiMethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-aMine oxalate
S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate in stock Factory
N,N-dimethyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine
Duloxetine Impurity 8 Oxalate
Duloxetine N-Methyl (S)-Isomer Oxalate
(S)-(+) N,N-dimethyl-3-(1-napthalenyloxy)-3-(2_thieyl)prapanamine oxalate
Duloxetine N-methyl Impurity
Duloxetine Impurity 52
S-(+)-N,N-dimethtl-3-(1-naphthoxy)-3-(2-thienyl)-1-propanamine oxalate
2-Thiophenepropanamine, N,N-dimethyl-γ-(1-naphthalenyloxy)-, ethanedioate (1:1), (γS)-
(3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine Oxalate)
Duloxetine Impurity 8(Oxalicacid)
(3S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine ethanedioate
(3S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine Oxalate (N-Methylduloxetine
N-Methyl Duloxetine Oxalate
132335-47-8
C19H21NOSC2H2O4
Chiral Reagents
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds
