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4-chloropyridine

4-chloropyridine Structure
4-chloropyridine structure
CAS No.
626-61-9
Chemical Name:
4-chloropyridine
Synonyms
Pyridine, 4-chloro-;gamma-Chloropyridine;Trazodone Impurity 31;4-chloropyridine ISO 9001：2015 REACH
CBNumber:
CB3937772
Molecular Formula:
C5H4ClN
Molecular Weight:
113.54
MDL Number:
MFCD00044570
MOL File:
626-61-9.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:12
Product description Number Pack Size Price
4-Chloropyridine 95%+ 133694 500mg $365
4-CHLOROPYRIDINE 95.00% HCH0101467 5MG $505.78
4-Chloropyridine 95%+ 133694 1g $645
4-Chloropyridine 626619 250mg $680
4-Chloropyridine 626619 1g $1685
More product size
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4-chloropyridine Properties

Melting point -43.5°C
Boiling point 147℃
Density 1.200
refractive index 1.5304 (estimate)
Flash point 53℃
pka 3.18±0.10(Predicted)
EWG's Food Scores 1

SAFETY

Risk and Safety Statements

Hazardous Substances Data 626-61-9(Hazardous Substances Data)

4-chloropyridine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 133694 4-Chloropyridine 95%+ 626-61-9 500mg $365 2021-12-16 Buy
American Custom Chemicals Corporation HCH0101467 4-CHLOROPYRIDINE 95.00% 626-61-9 5MG $505.78 2021-12-16 Buy
Matrix Scientific 133694 4-Chloropyridine 95%+ 626-61-9 1g $645 2021-12-16 Buy
Alichem 626619 4-Chloropyridine 626-61-9 250mg $680 2021-12-16 Buy
Alichem 626619 4-Chloropyridine 626-61-9 1g $1685 2021-12-16 Buy
Product number Packaging Price Buy
133694 500mg $365 Buy
HCH0101467 5MG $505.78 Buy
133694 1g $645 Buy
626619 250mg $680 Buy
626619 1g $1685 Buy

4-chloropyridine Chemical Properties,Uses,Production

Uses

4-Chloropyridine is an inhibitor of nicotinamide N-methyltransferase (NNMT). It can act as a substrate for NNMT and, during its catalytic reaction, enhances the electrophilicity of the C4 position by methylating the nitrogen atom of the pyridine ring. This promotes an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to the suicide inhibition of NNMT's activity. 4-Chloropyridine holds potential for the development of NNMT activity-based probes [1].

Purification Methods

Pour 4-chloropyridine into distilled water, and excess of 6M NaOH is added to give pH 12. The organic phase is separated and extracted with four volumes of diethyl ether. The combined extracts are filtered through paper to remove water, and the solvent is evaporated. The dark brown residual liquid is kept under high vacuum [Vaidya & Mathias J Am Chem Soc 108 5514 1986]. It can be distilled, but readily darkens and is best kept as the hydrochloride [7379-35-3] M 150.1, m 163-165o(dec). [Beilstein 20/5 V 410.]

References

[1] Sen S, et al. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol. 2019 Apr 19;14(4):613-618. DOI:10.1021/acschembio.9b00211

4-chloropyridine synthesis

110-86-1
626-61-9
Synthesis of 4-chloropyridine from Pyridine

4-chloropyridine Preparation Products And Raw materials

Raw materials

N-Nitropyridin-4-amine 4,4'-DICHLORO-2,2'-BIPYRIDINE 4-Chloropyridine N-oxide 4-CHLORO-2-TRIMETHYLSILYLPYRIDINE CHLORIDE STANDARD
BENZOPHENONE AZINE N-(4-Pyridyl)pyridinium chloride hydrochloride

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Preparation Products

4,4'-Bipyridine 4-Mercaptopyridine 2-Bromo-4-chloropyridine 4,4'-DIPYRIDYL SULFIDE 4-(2-HYDROXYETHYLAMINO)-PYRIDINE
4-CHLORO-3-IODOPYRIDINE 4-CHLOROPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER 98 3-Chloropyridine 4-Phenoxypyridine

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4-chloropyridine Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
GIHI CHEMICALS CO.,LIMITED 		+86-571-86217390; +8618058761490 info@gihichemicals.com China 49968 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Shandong Liteng Biotechnology Co. , Ltd. 		+86-18663721413 +86-15552573001 rosy@litengpharm.com China 3280 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
CONIER CHEM AND PHARMA LIMITED 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
GIHI CHEMICALS CO.,LIMITED 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Shandong Liteng Biotechnology Co. , Ltd. 		58

View Lastest Price from 4-chloropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-chloropyridine pictures 2025-11-18 4-chloropyridine
626-61-9
 US $1.10 / g 1g 99.00% 100 Tons min Dideu Industries Group Limited

4-chloropyridine Spectrum

4-chloropyridine(626-61-9)1HNMR

626-61-9(4-chloropyridine)Related Search:

2-[3-[Bis(2-chloroethyl)aMino]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one Trazodone-D6 Hydrochloride 2,6-Dichloropyridine Isotrazodone Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-
Trazodone Hydrochloride BP Impurity H DiHCl Trazodone 4-Hydroxytrazodone BIUREA 1-(4-Chlorophenyl)-4-(3-chloropropyl)piperazine
1-(3-Chlorophenyl)piperazine-d8 1-(3-Bromophenyl)piperazine MYRISTIC ACID DIETHANOLAMIDE 2,4-Dichloroaniline 3-Bromo-2-fluoropyridine
2,3,5-Collidine 6-BENZYL-5,7-DIOXO-OCTAHYDROPYRROLO[3,4-B] PYRIDINE 2-Hydroxy-4-methyl-5-nitropyridine

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gamma-Chloropyridine Pyridine, 4-chloro- Trazodone Impurity 31 4-chloropyridine ISO 9001：2015 REACH 626-61-9