JNJ-10198409
- CAS No.
- 627518-40-5
- Chemical Name:
- JNJ-10198409
- Synonyms
- RWJ 540973;JNJ-10198409;JNJ-10198409, Free Base;JNJ-10198409 (JNJ10198409);JNJ-10198409, 10 mM in DMSO;JNJ-10198409 >=98% (HPLC), solid;PDGFR Tyrosine Kinase Inhibitor IV;JNJ-10198409, PDGF-BB tyrosine kinase inhibitor;JNJ-10198409 (This product is only available in Japan.);PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem
- CBNumber:
- CB3972168
- Molecular Formula:
- C18H16FN3O2
- Molecular Weight:
- 325.34
- MDL Number:
- MFCD11045292
- MOL File:
- 627518-40-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| JNJ-10198409 ≥98% (HPLC), solid | J4649 | 1mg | $225 |
| PDGFR Tyrosine Kinase Inhibitor IV | 521233 | 1mg | $229 |
| JNJ-10198409 | J0010 | 10MG | $219 |
| JNJ-10198409 | J0010 | 50MG | $657 |
| JNJ-10198409 ≥98% | 10008131 | 1mg | $31 |
| Melting point | 171-173.5 °C |
|---|---|
| Boiling point | 528.8±50.0 °C(Predicted) |
| Density | 1.366±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO: >10mg/mL |
| form | solid |
| pka | 14.01±0.20(Predicted) |
| color | off-white |
| InChI | 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22) |
| InChIKey | ZDNURMVOKAERHZ-UHFFFAOYSA-N |
| SMILES | COc1cc2Cc3c(Nc4cccc(F)c4)n[nH]c3-c2cc1OC |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
JNJ-10198409 price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | J4649 | JNJ-10198409 ≥98% (HPLC), solid | 627518-40-5 | 1mg | $225 | 2026-04-30 | Buy |
| Sigma-Aldrich | 521233 | PDGFR Tyrosine Kinase Inhibitor IV | 627518-40-5 | 1mg | $229 | 2026-04-30 | Buy |
| TCI Chemical | J0010 | JNJ-10198409 | 627518-40-5 | 10MG | $219 | 2026-04-30 | Buy |
| TCI Chemical | J0010 | JNJ-10198409 | 627518-40-5 | 50MG | $657 | 2026-04-30 | Buy |
| Cayman Chemical | 10008131 | JNJ-10198409 ≥98% | 627518-40-5 | 1mg | $31 | 2026-04-30 | Buy |
JNJ-10198409 Chemical Properties,Uses,Production
Uses
JNJ-10198409 is a relatively selective, orally active, and ATP competitive PDGF-RTK (platelet-derived growth factor receptor tyrosine kinase) inhibitor (IC50=2 nM). It is a dual-mechanism, antiangiogenic, and tumor cell antiproliferative agent. JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) and PDGFR-α kinase (IC50=45 nM)[1][2].
Biological Activity
jnj-10198409 is a small molecule inhibitor of platelet-derived growth factor (pdgf-bb) tyrosine kinase [1].platelet-derived growth factor (pdgf) is a ubiquitous mitogen involved in regulating cell growth and division, embryonic development, cell proliferation, cell migration, and angiogenesis. overexpression of pdgf has been associated with several diseases such as atherosclerosis, fibrotic disorders and malignancies. inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (pdgf-bb) receptor can have potent antiangiogenic and antiproliferative activity. recombinant pdgf is used in medicine to help heal chronic ulcers and in orthopedic surgery and periodontistry to treat bone loss [2].in human coronary artery smooth muscle cells, jnj-10198409 inhibited the activity of platelet-derived growth factor (pdgf-bb) tyrosine kinase with an ic50 value of 4.2 nm when tested. jnj-10198409 was a competitive antagonist of the atp binding and hydrolysis at pdgf-bb receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis [1].
IC 50
PDGFRβ: 4.2 nM (IC50); PDGFRα: 45 nM (IC50)
storage
Store at -20°C
References
[1] ho c y, ludovici d w, maharoof u s m, et al. (6, 7-dimethoxy-2, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells[j]. journal of medicinal chemistry, 2005, 48(26): 8163-8173.
[2] raines e w, bowen-pope d f, ross r. platelet-derived growth factor[m]//peptide growth factors and their receptors i. springer berlin heidelberg, 1990: 173-262.
JNJ-10198409 Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ-10198409 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15402 | 60 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15178 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
View Lastest Price from JNJ-10198409 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | JNJ-10198409
627518-40-5
|
$29.00-131.00 | 98.51% | 10g | TargetMol Chemicals Inc. |
-
- JNJ-10198409
627518-40-5
- $29.00-131.00
- 98.51%
- TargetMol Chemicals Inc.
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