ChemicalBook >> CAS DataBase List >>NS1643
NS1643
- CAS No.
- 448895-37-2
- Chemical Name:
- NS1643
- Synonyms
- NS1643, >98%;NS1643 ，S5773;NS-1643;NS 1643;NS1643, 10 mM in DMSO;NS-1643;NS1643;NS 1643;1,3-bis(5-(trifluoromethyl)-2-hydroxyphenyl)urea;N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea;Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-;KcsA,NS1643,NS 1643,Potassium Channel,Inhibitor,inhibit,NS-1643,Autophagy
- CBNumber:
- CB3972395
- Molecular Formula:
- C15H10F6N2O3
- Molecular Weight:
- 380.24
- MDL Number:
- MFCD08705418
- MOL File:
- 448895-37-2.mol
- MSDS File:
- SDS
Last updated:2026-02-25 11:45:28
| Product description | Number | Pack Size | Price |
| NS1643 ≥98% (HPLC), solid | N0663 | 5mg | $246.05 |
| NS1643 ≥98% (HPLC), solid | N0663 | 25mg | $776 |
| NS 1643 ≥98% | 20343 | 5mg | $44 |
| NS 1643 ≥98% | 20343 | 10mg | $84 |
| NS 1643 ≥98% | 20343 | 25mg | $172 |
| More product size | |||
| Boiling point | 342.3±42.0 °C(Predicted) |
|---|---|
| Density | 1.626±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | solid |
| pka | 6.84±0.13(Predicted) |
| color | white to off-white |
| FDA UNII | 0I579CNG0I |
NS1643 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0663 | NS1643 ≥98% (HPLC), solid | 448895-37-2 | 5mg | $246.05 | 2025-07-31 | Buy |
| Sigma-Aldrich | N0663 | NS1643 ≥98% (HPLC), solid | 448895-37-2 | 25mg | $776 | 2022-05-15 | Buy |
| Cayman Chemical | 20343 | NS 1643 ≥98% | 448895-37-2 | 5mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 20343 | NS 1643 ≥98% | 448895-37-2 | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 20343 | NS 1643 ≥98% | 448895-37-2 | 25mg | $172 | 2024-03-01 | Buy |
NS1643 Chemical Properties,Uses,Production
Uses
NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator.
Biological Activity
Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro .
in vivo
NS1643 (6 mg/kg; i.p., twice per week) inhibits breast tumor metastasis[2].
| Animal Model: | NSG mice with human-derived TNBC tumor xenografts[2] |
| Dosage: | 6 mg/kg |
| Administration: | Intraperitoneal injection; 6 mg/kg; twice per week |
| Result: | Significantly reduceed tumor growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA). |
storage
+4°C
NS1643 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 90)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30228 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39043 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 |
View Lastest Price from NS1643 manufacturers
448895-37-2(NS1643)Related Search:
N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
NS-1643;NS 1643
NS1643, >98%
NS-1643;NS1643;NS 1643
Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-
1,3-bis(5-(trifluoromethyl)-2-hydroxyphenyl)urea
KcsA,NS1643,NS 1643,Potassium Channel,Inhibitor,inhibit,NS-1643,Autophagy
NS1643, 10 mM in DMSO
NS1643 ，S5773
448895-37-2
C15H10F6N2O3
