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ChemicalBook >> CAS DataBase List >>4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Structure
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- structure
CAS No.
2044686-42-0
Chemical Name:
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-
Synonyms
TP1287;TP-1287;TP 1287;4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-
CBNumber:
CB39764737
Molecular Formula:
C21H21ClNO8P
Molecular Weight:
481.82
MDL Number:
MOL File:
2044686-42-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-05 09:01:00
Request For Quotation

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Properties

Boiling point 717.1±70.0 °C(Predicted)
Density 1.576±0.06 g/cm3(Predicted)
pka 1.58±0.10(Predicted)
form Solid
color Light yellow to yellow
FDA UNII 7MPP85IIJ3

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0675229 TP-1287 95.93% 2044686-42-0 5mg $596 2026-06-04 Buy
ChemScene CS-0675229 TP-1287 95.93% 2044686-42-0 10mg $953 2026-06-04 Buy
ChemScene CS-0675229 TP-1287 95.93% 2044686-42-0 25mg $1733 2026-06-04 Buy
ChemScene CS-0675229 TP-1287 95.93% 2044686-42-0 50mg $2773 2026-06-04 Buy
ChemScene CS-0675229 TP-1287 95.93% 2044686-42-0 100mg $4442 2026-06-04 Buy
Product number Packaging Price Buy
CS-0675229 5mg $596 Buy
CS-0675229 10mg $953 Buy
CS-0675229 25mg $1733 Buy
CS-0675229 50mg $2773 Buy
CS-0675229 100mg $4442 Buy

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Chemical Properties, Uses, Production

Uses

TP-1287, a prodrug of Alvocidib (HY-10005), is an orally active CDK9 inhibitor[1].

in vivo

TP-1287 (2.5-15 mg/kg; oral) suppresses tumor growth in models of multiple myeloma[1].
TP-1287 is highly soluble over a broader pH range than Alvocidib (HY-10005) and is efficiently metabolized to the parent compound in vivo, following oral administration[2].

Animal Model:RPMI-8226 xenograft model for multiple myeloma[1]
Dosage:2.5, 7.5, and 15 mg/kg
Administration:Oral
Result:Achieved tumor growth inhibition (%TGI) of 56.0, 76.6, and 93.9% at doses of 2.5, 7.5, and 15 mg/kg, respectively.

IC 50

CDK9

References

[1] Tyagi E, et al. The Oral CDK9 Inhibitor, TP-1287, Is Active in Non-Clinical Models of Multiple Myeloma. Blood, 2018, 132: 3269.
[2] Kim W, et al. TP-1287, an oral prodrug of the cyclin-dependent kinase-9 inhibitor alvocidib. Cancer Research, 2017, 77(13_Supplement): 5133-5133.

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Preparation Products And Raw materials

Raw materials

Preparation Products

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Suppliers

Global Suppliers ( 8)
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
Wuhan Sun-shine Bio-technology Corporation Limited +86-027-6552-2453 sales@sun-shinechem.com China 725 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9869 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd dexuanyiyao@126.com dexuanyiyao@126.com China 9470 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. hanfangpharma@126.com 15165037910 hanfangpharma@126.com China 25800 58
ChemOrigin Pharm 15026428026 19002516454 ChemOrigin@126.com China 1589 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
Wuhan Sun-shine Bio-technology Corporation Limited 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Shandong Dayou Pharmaceutical Research and Development Co., Ltd. 58
ChemOrigin Pharm 58
TargetMol Chemicals Inc. 58

View Latest Price from 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TP1287 pictures 2026-07-27 TP1287
2044686-42-0
 $1670.00-2800.00 10g TargetMol Chemicals Inc.
  • TP1287 pictures
  • TP1287
    2044686-42-0
  • $1670.00-2800.00
  • TargetMol Chemicals Inc.

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- Spectrum

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-(2044686-42-0)1HNMR

2044686-42-0 (4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)-) Related Search:

N-(5-(difluoromethoxy)-1H-pyrazol-3-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazolo[3,4-b]pyrazin-6-amine CDK12-CCNK HETERODIMER Protein, HUMAN (SF9) CDK3-CCNE1 HETERODIMER Protein, HUMAN (SF9) THZ1 OTS964 hydrochloride
GSK-3326595

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4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5-hydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-7-(phosphonooxy)- TP 1287 TP1287 TP-1287 2044686-42-0 C21H21ClNO8P