L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-
- CAS No.
- 2245195-67-7
- Chemical Name:
- L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-
- Synonyms
- HeE1-2Tyr;HeE1-2Tyr, 10 mM in DMSO;L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]-;(8-(Cyclohexyloxy)-1-oxo-2-phenyl-1H-benzo[4,5]thiazolo[3,2-a]pyridine-4-carbonyl)-L-tyrosine;HeE12Tyr,Nile,West,SARS-CoV,HeE1 2Tyr,SARS coronavirus,RdRp,HeE1-2Tyr,inhibit,HeE-1-2Tyr,flavivirus,Dengue,Inhibitor
- CBNumber:
- CB39799276
- Molecular Formula:
- C33H30N2O6S
- Molecular Weight:
- 582.67
- MDL Number:
- MOL File:
- 2245195-67-7.mol
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Properties
Boiling point | 842.3±65.0 °C(Predicted) |
---|---|
Density | 1.45±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : 100 mg/mL (171.62 mM; Need ultrasonic) |
form | Solid |
pka | 3.06±0.10(Predicted) |
color | White to yellow |
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Chemical Properties,Uses,Production
Uses
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro[1][2].
Biological Activity
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro[1][2]. HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 μM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 μM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 μM[1].Additionally, upon infection of human HEK 293 cells (CC50 of 50 μM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 μM[1]. HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].
References
[1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585.
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
L-Tyrosine, N-[[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b]benzothiazol-4-yl]carbonyl]- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 996 | 55 |
Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4868 | 58 |
Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2380 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24863 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |