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ChemicalBook >> CAS DataBase List >>4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Structure
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- structure
CAS No.
1438072-11-7
Chemical Name:
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-
Synonyms
Larotinib;rel-N-(3-Chloro-4-fluorophenyl)-6-(3-((4aR,7aS)-hexahydro-6H-[1,4]dioxino[2,3-c]pyrrol-6-yl)propoxy)-7-methoxyquinazolin-4-amine;4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-
CBNumber:
CB39806080
Molecular Formula:
C24H26ClFN4O4
Molecular Weight:
488.94
MDL Number:
MOL File:
1438072-11-7.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Properties

Boiling point 628.1±55.0 °C(Predicted)
Density 1.346±0.06 g/cm3(Predicted)
pka 8.06±0.20(Predicted)
form Solid
color White to off-white

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 44444 Larotinib ≥98% 1438072-11-7 1mg $40 2026-04-30 Buy
Cayman Chemical 44444 Larotinib ≥98% 1438072-11-7 5mg $180 2026-04-30 Buy
Cayman Chemical 44444 Larotinib ≥98% 1438072-11-7 10mg $320 2026-04-30 Buy
Cayman Chemical 44444 Larotinib ≥98% 1438072-11-7 25mg $550 2026-04-30 Buy
ChemScene CS-0650981 Larotinib 99.50% 1438072-11-7 5mg $238 2026-06-04 Buy
Product number Packaging Price Buy
44444 1mg $40 Buy
44444 5mg $180 Buy
44444 10mg $320 Buy
44444 25mg $550 Buy
CS-0650981 5mg $238 Buy

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Chemical Properties, Uses, Production

Uses

Larotinib is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM[1].

in vivo

After daily administration of Larotinib mesylate, the no observed adverse effect level (NOAEL) is 10 mg/kg in Sprague-Dawley rats and the lowest observed adverse effect level (LOAEL) is 5 mg/kg in beagle dogs. The maximal tolerable doses (MTDs) are 20 and 25 mg/kg in Sprague-Dawley rats and beagle dogs, respectively[1].
Larotinib mesylate shows dose-dependent antitumor results and a tumor-inhibiting rate exceeding 60% at 18 mg/kg in a tumor-bearing mice model (data not published)[1].

IC 50

EGFRL861Q: 0.423 nM (IC50); EGFRL858R: 0.563 nM (IC50); EGFR (WT): 0.611 nM (IC50); EGFRT790M: 45.2 nM (IC50); HER4: 84 nM (IC50); BLK: 102 nM (IC50); IRAK1: 167 nM (IC50); BTK: 196 nM (IC50); HER2: 253 nM (IC50)

References

[1] Liu J, et al. Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors. Front Pharmacol. 2021 Feb 18;12:636324. DOI:10.3389/fphar.2021.636324

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Preparation Products And Raw materials

Raw materials

Preparation Products

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Suppliers

Global Suppliers ( 15)
Supplier Tel Email Country ProdList Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9780 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007 cis@bioss.com.cn China 9185 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-5885952 15955137747 sales@aikonchem.com China 8012 58
Supplier Advantage
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
TargetMol Chemicals Inc. 58
Zhejiang Huida Biotech Co., LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Bide Pharmatech Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Beijing Boorsen Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58

View Latest Price from 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Larotinib pictures 2026-07-27 Larotinib
1438072-11-7
 $74.00-272.00 99.73% 10g TargetMol Chemicals Inc.
  • Larotinib pictures
  • Larotinib
    1438072-11-7
  • $74.00-272.00
  • 99.73%
  • TargetMol Chemicals Inc.

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- Spectrum

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-(1438072-11-7)1HNMR

1438072-11-7 (4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel-) Related Search:

N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine O-Desmethyl Gefitinib 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline hydrochloride 4-Defluoro-4-hydroxy Gefitinib linkable gefitinib analogue
4-[(3-chloro-4-fluoro-phenyl)amino]-6-(1-cyano-piperidin-4-yloxy)-7-methoxy-quinazoline

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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-[3-[(4aR,7aS)-hexahydro-6H-1,4-dioxino[2,3-c]pyrrol-6-yl]propoxy]-7-methoxy-, rel- rel-N-(3-Chloro-4-fluorophenyl)-6-(3-((4aR,7aS)-hexahydro-6H-[1,4]dioxino[2,3-c]pyrrol-6-yl)propoxy)-7-methoxyquinazolin-4-amine Larotinib 1438072-11-7 C24H26ClFN4O4