Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]-
![Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Structure](CAS/20210305/GIF/2438124-95-7.gif)
- CAS No.
- 2438124-95-7
- Chemical Name:
- Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]-
- Synonyms
- ALV2;Helios molecular glue degrader ALV2;3-(3-chloro-4-methylphenyl)-1-[2-(3-{[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}phenyl)propan-2-yl]urea;N-(3-Chloro-4-methylphenyl)-N′-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]urea;Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]-
- CBNumber:
- CB39820817
- Molecular Formula:
- C26H26ClN5O5
- Molecular Weight:
- 523.97
- MDL Number:
- MOL File:
- 2438124-95-7.mol
- MSDS File:
- SDS
Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Properties
| Boiling point | 724.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.444±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 160 mg/mL (305.36 mM; Need ultrasonic)| |
| pka | 10.69±0.40(Predicted) |
| form | Solid |
| color | White to yellow |
| Water Solubility | Water : < 0.1 mg/mL (insoluble) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501 |
Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0137056 | ALV2 ≥98% | 2438124-95-7 | 10mg | $800 | 2026-06-04 | Buy |
| aablocks | AA029J4X | 3-(3-chloro-4-methylphenyl)-1-[2-(3-{[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}phenyl)propan-2-yl]urea >98% | 2438124-95-7 | 5mg | $535 | 2026-06-02 | Buy |
| aablocks | AA029J4X | 3-(3-chloro-4-methylphenyl)-1-[2-(3-{[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}phenyl)propan-2-yl]urea 98% | 2438124-95-7 | 10mg | $640 | 2026-06-02 | Buy |
| aablocks | AA029J4X | 3-(3-chloro-4-methylphenyl)-1-[2-(3-{[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}phenyl)propan-2-yl]urea >98% | 2438124-95-7 | 50mg | $2869 | 2026-06-02 | Buy |
| aablocks | AA029J4X | 3-(3-chloro-4-methylphenyl)-1-[2-(3-{[1-(2,6-dioxopiperidin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]amino}phenyl)propan-2-yl]urea >98% | 2438124-95-7 | 100mg | $4369 | 2026-06-02 | Buy |
Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Chemical Properties, Uses, Production
Uses
ALV2 is a potent and selective Helios molecular glue degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1].
Biological Activity
ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC50 of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable Treg cell phenotype in the inflammatory tumor microenvironment[1]. ALV2 (10 nM-100 μM) induces CRBN-Helios dimerization in the TR-FRET assay[1].ALV2 (0.1-10 μM) preferentially promotes Helios degradation in Jurkat cells[1].ALV2 (1 μM; pretreated for 18 h) promotes IL-2 secretion in Jurkat cells[1]. ALV2 (100 mg/kg; i.p. twice daily for 7 days) induces selective Helios degradation in vivo[1].
in vivo
ALV2 (100 mg/kg; i.p. twice daily for 7 days) induces selective Helios degradation in vivo[1].
| Animal Model: | CrbnI391V/I391V mice |
| Dosage: | 100 mg/kg |
| Administration: | I.p. twice daily for 7 days |
| Result: | Reduced Helios, but not Ikaros, levels in splenic CD4+FoxP3+ Treg cells. |
IC 50
Cereblon
References
[1]. Wang ES, et, al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17(6):711-717.
Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1644 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Jinan Ruisi Pharmaceutical Technology Co., LTD | 0531-0531-69900633 19963472814 | changyuan20@163.com | China | 9938 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| ChemOrigin Pharm | 15026428026 19002516454 | ChemOrigin@126.com | China | 1581 | 58 |
2438124-95-7 (Urea, N-(3-chloro-4-methylphenyl)-N'-[1-[3-[[1-(2,6-dioxo-3-piperidinyl)-2,5-dihydro-2,5-dioxo-1H-pyrrol-3-yl]amino]phenyl]-1-methylethyl]-) Related Search:
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