3,6-Dimethyl-2-hydroxy benzaldehyde
- CAS No.
- 1666-04-2
- Chemical Name:
- 3,6-Dimethyl-2-hydroxy benzaldehyde
- Synonyms
- 3,6-Dimethylsalicylaldehyde;3,6-Dimethylsalicylaldehyde>3,6-Dimethyl-2-hydroxy benzaldehyde;Benzaldehyde, 2-hydroxy-3,6-dimethyl-;2-Hydroxy-3,6-dimethylbenzaldehyde (95%);2-hydroxy-3.6-dimethylbenzenemethylaldehyde;3,6-Dimethyl-2-formylphenol, 2-Formyl-3-hydroxy-p-xylene, 3,6-Dimethylsalicylaldehyde
- CBNumber:
- CB41010273
- Molecular Formula:
- C9H10O2
- Molecular Weight:
- 150.17
- MDL Number:
- MFCD04037328
- MOL File:
- 1666-04-2.mol
- MSDS File:
- SDS
| Melting point | 59.0 to 63.0 °C |
|---|---|
| Boiling point | 230.1±35.0 °C(Predicted) |
| Density | 1.136±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 8.63±0.15(Predicted) |
| color | White to Light yellow to Light orange |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| HS Code | 2912490090 | |||||||||
| NFPA 704 |
|
3,6-Dimethyl-2-hydroxy benzaldehyde price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4507 | 3,6-Dimethylsalicylaldehyde >98.0%(GC)(T) | 1666-04-2 | 1g | $185 | 2026-04-30 | Buy |
| TCI Chemical | D4507 | 3,6-Dimethylsalicylaldehyde >98.0%(GC)(T) | 1666-04-2 | 5g | $616 | 2026-04-30 | Buy |
| Apolloscientific | OR46065 | 3,6-Dimethyl-2-hydroxybenzaldehyde 97% | 1666-04-2 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR46065 | 3,6-Dimethyl-2-hydroxybenzaldehyde 97% | 1666-04-2 | 1g | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR46065 | 3,6-Dimethyl-2-hydroxybenzaldehyde 97% | 1666-04-2 | 5g | $86 | 2026-06-04 | Buy |
3,6-Dimethyl-2-hydroxy benzaldehyde Chemical Properties, Uses, Production
Uses
2-Hydroxy-3,6-dimethylbenzaldehyde
Synthesis
95-87-4
50-00-0
1666-04-2
To a solution of 2,5-dimethylphenol (7.0 g, 57.3 mmol) in acetonitrile (250 mL) was sequentially added triethylamine (30.1 mL, 0.212 mol) and magnesium chloride (8.17 g, 86 mmol). The reaction mixture was stirred at room temperature for 15 minutes before adding paraformaldehyde (11.5 g, 0.38 mol). Subsequently, the mixture was heated to 80 °C and kept for 20 hours. After completion of the reaction, acetonitrile was removed by distillation under reduced pressure. A 10% hydrochloric acid solution was added to the residue and stirred for 30 min at room temperature. The mixture was extracted with dichloromethane (2 x 40 mL), the organic layers were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting crude product was purified by fast column chromatography on silica gel (eluent: dichloromethane) to afford the target product 3,6-dimethyl-2-hydroxybenzaldehyde (27a) (3.56 g, 23.7 mmol, 42% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.21 (s, 3H), 2.57 (s, 3H), 6.62 (d, J = 8.0 Hz, 1H), 7.24 (d, J = 8.0 Hz, 1H), 10.30 (s, 1H), 12.18 (s, 1H).
References
[1] Journal of Organometallic Chemistry, 2005, vol. 690, # 23, p. 5125 - 5144
[2] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584
[3] Patent: WO2012/140243, 2012, A1. Location in patent: Page/Page column 137-138
[4] Journal of Organic Chemistry, 2013, vol. 78, # 14, p. 6890 - 6910
[5] Patent: US2016/152543, 2016, A1. Location in patent: Paragraph 1197; 1198; 1199
3,6-Dimethyl-2-hydroxy benzaldehyde Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
3,6-Dimethyl-2-hydroxy benzaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4904 | 55 |
| Tianjin Ji Ping Jia Chemical Co., Ltd. | 18622448868 | jpjchem@163.com | China | 473 | 62 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from 3,6-Dimethyl-2-hydroxy benzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 2-Hydroxy-3,6-dimethylbenzaldehyde
1666-04-2
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2020-01-08 | 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
1666-04-2
|
$3.00 | 1KG | 98%min | 200KG | Career Henan Chemical Co |
-
- 2-Hydroxy-3,6-dimethylbenzaldehyde
1666-04-2
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
1666-04-2
- $3.00
- 98%min
- Career Henan Chemical Co
