JUN-1111
- CAS No.
- 874351-38-9
- Chemical Name:
- JUN-1111
- Synonyms
- JUN1111;JUN-1111;JUN 1111
- CBNumber:
- CB411075747
- Molecular Formula:
- C15H17N3O3
- Molecular Weight:
- 287.32
- MDL Number:
- MOL File:
- 874351-38-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| form | Solid |
|---|---|
| color | Orange to reddish brown |
| FDA UNII | FM4058Y01H |
JUN-1111 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066277 | JUN-1111 98.57% | 874351-38-9 | 5mg | $265 | 2026-06-04 | Buy |
| ChemScene | CS-0066277 | JUN-1111 98.57% | 874351-38-9 | 10mg | $412 | 2026-06-04 | Buy |
| ChemScene | CS-0066277 | JUN-1111 98.57% | 874351-38-9 | 25mg | $867 | 2026-06-04 | Buy |
| ChemScene | CS-0066277 | JUN-1111 98.57% | 874351-38-9 | 50mg | $1387 | 2026-06-04 | Buy |
| ChemScene | CS-0066277 | JUN-1111 98.57% | 874351-38-9 | 100mg | $2275 | 2026-06-04 | Buy |
JUN-1111 Chemical Properties, Uses, Production
Uses
JUN-1111 is an irreversible and selective Cdc25 phosphatase inhibitor with IC50 values of 0.38, 1.8, 0.66, 28, 37 μM for Cdc25A, Cdc25B, Cdc25C, VHR, PTP1B, respectively. JUN-1111 induces cell cycle arrest at G1 and G2/M phases. JUN-1111 decreases the expression of phosphoCdk1[1][2].
References
[1] Brisson M, et al. Redox regulation of Cdc25B by cell-active quinolinediones. Mol Pharmacol. 2005 Dec;68(6):1810-20. DOI:10.1124/mol.105.016360
[2] Vogt A, et al. A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Mol Cancer Ther. 2008 Feb;7(2):330-40. DOI:10.1158/1535-7163.MCT-07-2165
JUN-1111 Preparation Products And Raw materials
Raw materials
Preparation Products
JUN-1111 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
