N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
![N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Structure](CAS/20200119/GIF/519178-28-0.gif)
- CAS No.
- 519178-28-0
- Chemical Name:
- N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
- Synonyms
- TNP;IP6K Inhibitor;IP3K Inhibitor;TNP >=95% (HPLC);TNP, 10 mM in DMSO;IP6K1 inhibitor TNP;IP6K1 inhibitor TNP (TNP);IP6K Inhibitor - CAS 519178-28-0 - Calbiochem;N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine;N6-(4-Nitrobenzyl)-N2-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine
- CBNumber:
- CB41128943
- Molecular Formula:
- C20H16F3N7O2
- Molecular Weight:
- 443.38
- MDL Number:
- MFCD16875436
- MOL File:
- 519178-28-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| TNP ≥95% (HPLC) | T3955 | 5mg | $255 |
| TNP ≥95% (HPLC) | T3955 | 25mg | $640.05 |
| IP6K Inhibitor - CAS 519178-28-0 - Calbiochem The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K. | 406170 | 5mg | $238 |
| TNP ≥98% | 21189 | 1mg | $49 |
| TNP ≥98% | 21189 | 5mg | $158 |
| Boiling point | 723.4±70.0 °C(Predicted) |
|---|---|
| Density | 1.543±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | Yellow solid |
| pka | 10.51±0.10(Predicted) |
| color | yellow |
| InChI | 1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29) |
| InChIKey | DDSBPUYZPWNNGH-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T3955 | TNP ≥95% (HPLC) | 519178-28-0 | 5mg | $255 | 2026-04-30 | Buy |
| Sigma-Aldrich | T3955 | TNP ≥95% (HPLC) | 519178-28-0 | 25mg | $640.05 | 2026-04-30 | Buy |
| Sigma-Aldrich | 406170 | IP6K Inhibitor - CAS 519178-28-0 - Calbiochem The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K. | 519178-28-0 | 5mg | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 21189 | TNP ≥98% | 519178-28-0 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 21189 | TNP ≥98% | 519178-28-0 | 5mg | $158 | 2026-04-30 | Buy |
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Chemical Properties,Uses,Production
Uses
TNP provides a means of selectively and rapidly modulating cellular InsP7 levels in vivo without affecting levels of other inositol phosphates.
Biochem/physiol Actions
TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.
in vivo
TNP (10 mg/kg; i.p.; daily; 10 weeks) significantly reduces body weight and improves insulin resistance in male C57BL/6 mice with high-fat diet-induced obesity (DIO)[1]. TNP (20 mg/kg; i.p.; daily; 18 days) decreases fat accumulation and enhances insulin sensitivity in male C57BL/6 mice with short-term reversal of obesity[1].
storage
Store at +4°C
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Preparation Products And Raw materials
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 3000 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
