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3,4,5-Trimethoxyaniline

3,4,5-Trimethoxyaniline structure

CAS No.: 24313-88-0

Chemical Name:: 3,4,5-Trimethoxyaniline

Synonyms: 3,4,5-Trimethoxy;3,4,5-trimethoxy-benzenamin;3,4,5-triMethoxybenzenaMine;NSC 37006;TriMethoxyaniline;5-Trimethoxyaniline;3,4,5-TrimethoxyaniL;4,5-Trimethoxyaniline;3,4,5-TRIMETHOXYANILINE;3,4,5-TRIMOTHOXYANILINE

CBNumber:: CB4117296

Molecular Formula:: C9H13NO3

Molecular Weight:: 183.2

MDL Number:: MFCD00008393

MOL File:: 24313-88-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:19:48

Product description	Number	Pack Size	Price
3,4,5-Trimethoxyaniline 97%	T68209	10g	$60.4
3,4,5-Trimethoxyaniline 97%	T68209	25g	$86.3
3,4,5-Trimethoxyaniline >98.0%(GC)(T)	T1055	5g	$68
3,4,5-Trimethoxyaniline >98.0%(GC)(T)	T1055	25g	$318
3,4,5-Trimethoxyaniline	T795670	10g	$70
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3,4,5-Trimethoxyaniline Properties

Melting point	110-113 °C (lit.)
Boiling point	316.88°C (rough estimate)
Density	1.1967 (rough estimate)
refractive index	1.4760 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	4.35±0.10(Predicted)
form	Powder
color	Off-white to beige-brown, gray, or pink
BRN	642919
InChI	InChI=1S/C9H13NO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,10H2,1-3H3
InChIKey	XEFRNCLPPFDWAC-UHFFFAOYSA-N
SMILES	C1(N)=CC(OC)=C(OC)C(OC)=C1
CAS DataBase Reference	24313-88-0(CAS DataBase Reference)
EPA Substance Registry System	3,4,5-Trimethoxyaniline (24313-88-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P304+P340+P312

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

37/38-36/37/38-20/21/22

Safety Statements

22-24/25-37/39-26-24-36

RIDADR

2811

WGK Germany

Hazard Note

Harmful

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29222900

Storage Class

11 - Combustible Solids

Hazard Classifications

Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

3,4,5-Trimethoxyaniline price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T68209	3,4,5-Trimethoxyaniline 97%	24313-88-0	10g	$60.4	2025-07-31	Buy
Sigma-Aldrich	T68209	3,4,5-Trimethoxyaniline 97%	24313-88-0	25g	$86.3	2025-07-31	Buy
TCI Chemical	T1055	3,4,5-Trimethoxyaniline >98.0%(GC)(T)	24313-88-0	5g	$68	2025-07-31	Buy
TCI Chemical	T1055	3,4,5-Trimethoxyaniline >98.0%(GC)(T)	24313-88-0	25g	$318	2025-07-31	Buy
TRC	T795670	3,4,5-Trimethoxyaniline	24313-88-0	10g	$70	2021-12-16	Buy

Product number	Packaging	Price	Buy
T68209	10g	$60.4	Buy
T68209	25g	$86.3	Buy
T1055	5g	$68	Buy
T1055	25g	$318	Buy
T795670	10g	$70	Buy

3,4,5-Trimethoxyaniline Chemical Properties,Uses,Production

Chemical Properties

3,4,5-Trimethoxyaniline is off-white to beige-brown, grey or pink powder

Uses

3,4,5-Trimethoxyaniline is a tri-substituted aniline derivative with sympatholytic activity. It is used in the preparation of a novel class of anticancer agents.

Application

3,4,5-Trimethoxyaniline can be used:
(1) As experimental studies, infrared spectra and laser Raman spectra of 3,4,5-trimethoxyaniline were investigated^[1].
(2) Tropanilisation, detropanilisation and Schiff base formation in the reaction of 3,4,5-trimethoxyaniline with tropanilide ions as organic reaction reagents^[2].

Application

[1] BANDANA SHARMA; Shweta P; Munish Kumar Yadav. MOLECULAR STRUCTURE, EXPERIMENTAL AND THEORETICAL (HF, DFT) SPECTRAL ANALYSIS OF 3,4,5- TRIMETHOXYANILINE[J]. Rasayan Journal of Chemistry, 2023. DOI:10.31788/rjc.2023.1628371.
[2] J. TSUNETSUGU; S. E; M SATO. ChemInform Abstract: TROPENYLATION, DETROPENYLATION AND SCHIFF BASE FORMATION IN THE REACTION OF 3,4,5-TRIMETHOXYANILINE WITH TROPENYLIUM ION[J]. ChemInform, 1975. DOI:10.1002/chin.197545221.

Synthesis

6307-90-0

24313-88-0

Step B / Intermediate B9: Synthesis of 3,4,5-trimethoxyaniline To a solution of 1,2,3-trimethoxy-5-nitrobenzene (6.64 g, 31.2 mmol) in ethanol (250 mL) was added palladium carbon (10%, 300 mg) and hydrazine hydrate (85%, 5.7 mL). The reaction mixture was heated to reflux for 1 hour after gas release ceased. Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration followed by evaporation of the solvent to afford 3,4,5-trimethoxyaniline (5.5 g, 96.4% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.86 (s, 2H), 4.82 (br, 2H), 3.64 (s, 6H), 3.50 (s, 3H).

References

[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 60
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 9, p. 3414 - 3425
[3] Chemische Berichte, 1888, vol. 21, p. 615
[4] Australian Journal of Scientific Research, Series A: Physical Sciences, 1950, vol. 3, p. 467,500
[5] Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59

3,4,5-Trimethoxyaniline synthesis

Synthesis of 3,4,5-Trimethoxyaniline from 1,2,3-TRIMETHOXY-5-NITROBENZENE

3,4,5-Trimethoxyaniline Preparation Products And Raw materials

Raw materials

Benzamide,N-hydroxy-3,4,5-trimethoxy- 1,2,3-TRIMETHOXY-5-NITROBENZENE 3,4,5-TRIMETHOXYPHENYLMAGNESIUM BROMIDE SOLUTION 0.5M IN TETRAHYDROFURAN 5-IODO-1,2,3-TRIMETHOXYBENZENE 3,4,5-TRIMETHOXYBENZAMIDE

1-Bromo-3,4,5-trimethoxybenzene 3,4,5-Trimethoxyphenylboronic acid 3,4,5-Trimethoxy benzoic acid Dimethyl carbonate Ammonium hydroxide

3,4,5-Trimethoxybenzoyl chloride

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Preparation Products

3,4,5-Trimethoxyphenol

3,4,5-Trimethoxyaniline Suppliers

Global( 335)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ROSEWA HOLDING GROUP CO.,LIMITED	+86-023-62871537	sales@rosewachem.com	China	2813	58
Zhejiang Karry Pharmachem Co., Ltd.	+8613567161161	info@karrypharma.com	China	34	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58

Supplier	Advantage
ROSEWA HOLDING GROUP CO.,LIMITED	58
Zhejiang Karry Pharmachem Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shanghai Arbor Chemical Co., Ltd.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 3,4,5-Trimethoxyaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-30	3,4,5-Trimethoxyaniline 24313-88-0	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-05-23	3,4,5-Trimethoxyaniline 24313-88-0	US $10.00 / kg	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
2025-04-04	3,4,5-Trimethoxyaniline 24313-88-0	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

3,4,5-Trimethoxyaniline
24313-88-0
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

3,4,5-Trimethoxyaniline
24313-88-0
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

3,4,5-Trimethoxyaniline
24313-88-0
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

3,4,5-Trimethoxyaniline Spectrum

3,4,5-Trimethoxyaniline(24313-88-0)¹HNMR 3,4,5-Trimethoxyaniline(24313-88-0)FT-IR 3,4,5-Trimethoxyaniline(24313-88-0)Raman 3,4,5-Trimethoxyaniline(24313-88-0)IR

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Trimetrexate N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE 2,4,5-Trimethoxyaniline 1,2,3-TRIMETHOXY-5-NITROBENZENE 3,4,5-TRIMETHOXY-ACETOACETANILIDE

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3,4,5-TRIMOTHOXYANILINE TriMethoxyaniline 3,4,5-TRIMETHOXYANILINE 3,4,5-TRIMETHOXYPHENYLAMINE 3,4,5-trimethoxy-benzenamin 3,4,5-Trimethoxy 3,4,5-Trimethoxyaniline 98% Benzenamine, 3,4,5-trimethoxy- 3,4,5-Trimethoxyaniline,97% 3,4,5-TRIMETHOXYANILINE 98+% 4,5-Trimethoxyaniline [3,4,5-Tris(Methyloxy)phenyl]aMine 3,4,5-Tris(Methyloxy)aniline NSC 37006 3,4,5-triMethoxybenzenaMine 3,4,5-TriMethoxyaniline, 97% 10GR 3,4,5-TrimethoxyaniL 3,4,5-Trimethoxyaniline ISO 9001：2015 REACH 5-Trimethoxyaniline 24313-88-0 CH3O3C6H2NH2 AMINE Building Blocks Amines C9 to C10 Organic Building Blocks Nitrogen Compounds amine Aromatics Intermediates & Fine Chemicals Pharmaceuticals Anilines, Aromatic Amines and Nitro Compounds Amines C9 to C10 Nitrogen Compounds