Oroxylin A
- CAS No.
- 480-11-5
- Chemical Name:
- Oroxylin A
- Synonyms
- 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one;Oroxylin;OLOXYLINA;oxoxylin A;Oroxylia A;OROXYLIN A;6-Methoxybaicalein;Baicalein Impurity 8;Baicalein 6-methyl ether;Oroxylin A, 10 mM in DMSO
- CBNumber:
- CB41179394
- Molecular Formula:
- C16H12O5
- Molecular Weight:
- 284.26
- MDL Number:
- MFCD02259441
- MOL File:
- 480-11-5.mol
| Melting point | 195-197℃ |
|---|---|
| Boiling point | 346.76°C (rough estimate) |
| Density | 1.420 |
| refractive index | 1.6200 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml |
| pka | 6.48±0.40(Predicted) |
| form | powder |
| color | Yellow |
| InChI | InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3 |
| InChIKey | LKOJGSWUMISDOF-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=CC=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 |
| FDA UNII | 53K24Z586G |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| NFPA 704 |
|
Oroxylin A price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82615 | Oroxylin A phyproof® Reference Substance | 480-11-5 | 10 mg | $431 | 2025-07-31 | Buy |
| TCI Chemical | O0635 | Oroxylin A | 480-11-5 | 250MG | $216 | 2025-07-31 | Buy |
| Cayman Chemical | 27363 | Oroxylin A | 480-11-5 | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 27363 | Oroxylin A | 480-11-5 | 25mg | $1139 | 2024-03-01 | Buy |
| Cayman Chemical | 27363 | Oroxylin A | 480-11-5 | 5mg | $343 | 2024-03-01 | Buy |
Oroxylin A Chemical Properties,Uses,Production
Uses
food and beverages
Definition
ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.
Biological Activity
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administration, or by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activations, iNOS expression, lipid peroxidation, and increased cholinergic neurotransmission after subchronic administration.
Synthesis
973-67-1
480-11-5
The general procedure for the synthesis of 5,7-dihydroxy-6-methoxy-2-phenyl-4H-benzopyran-4-one from 5,6,7-trimethoxy-2-phenyl-4H-benzopyran-4-one was as follows: 5,6,7-trimethoxy-2-phenyl-4H-benzopyran-4-one (0.20 g, 0.64 mmol) was dissolved in a mixture of 47% hydrobromic acid (5 mL) and glacial acetic acid (10 mL) in a mixed solution and the reaction was refluxed for 2 hours. Upon completion of the reaction, the reaction solution was quenched by carefully pouring it into crushed ice (200 g). The resulting yellow precipitate was collected by filtration and recrystallized from ethanol to afford 5,7-dihydroxy-6-methoxy-2-phenyl-4H-benzopyran-4-one (160 mg, 88% yield) with a melting point of 203-204 °C. The product structure was determined by 1H-NMR. The structure of the product was confirmed by 1H-NMR (DMSO-d6), IR, UV and MS analysis: 1H-NMR (DMSO-d6) δ: 3.91 (3H, s), 6.94 (1H, s), 6.98 (1H, s), 7.59 (3H, m), 8.10 (2H, d, J = 6.3 Hz), 8.77 (1H, s), 12.49 (1H, s); IR (KBr) cm-1: 3435, 1667; UV λmax (EtOH) nm (log ε): 322 (4.12), 278 (4.35), 216 (4.42); MS m/z: 285 (MH+).
References
[1] Chemical and pharmaceutical bulletin, 2003, vol. 51, # 3, p. 339 - 340
[2] Patent: US2004/242907, 2004, A1. Location in patent: Page 3
[3] Chemistry and Biodiversity, 2015, vol. 12, # 2, p. 259 - 272
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2534 - 2535
Oroxylin A Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | trade.kilopharma@foxmail.com | China | 27 | 58 |
| Hubei Danding Pharmaceutical Technology Co., Ltd | +86-18917019315 +86-13173601896 | 3582572959@qq.com | China | 496 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3178 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12636 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 299 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
View Lastest Price from Oroxylin A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-11 | Oroxylin A
480-11-5
|
US $0.00-0.00 / KG | 1KG | 99% | 5000 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2025-08-08 | Oroxylin A
480-11-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-07-25 | Oroxylin A
480-11-5
|
US $80.00 / mL | 99.67% | 10g | TargetMol Chemicals Inc. |
-
- Oroxylin A
480-11-5
- US $0.00-0.00 / KG
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Oroxylin A
480-11-5
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- Oroxylin A
480-11-5
- US $80.00 / mL
- 99.67%
- TargetMol Chemicals Inc.
