Methyl methanesulfonate
- CAS No.
- 66-27-3
- Chemical Name:
- Methyl methanesulfonate
- Synonyms
- MMS;Methyl mesylate;Methanesulphonic acid methyl ester;CB 1540;FDA 0092;NSC-50256;methylmesylate;MethylMethanes;as-dimethylsulfite;as-dimethylsulphite
- CBNumber:
- CB4119412
- Molecular Formula:
- C2H6O3S
- Molecular Weight:
- 110.13
- MDL Number:
- MFCD00007557
- MOL File:
- 66-27-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl methanesulfonate 99% | 129925 | 5g | $65.6 |
| Methyl methanesulfonate 99% | 129925 | 25g | $158 |
| Methyl methanesulfonate for synthesis | 8.20775 | 25mL | $151 |
| Methyl Methanesulfonate min. 98.0 % | M0369 | 5G | $22 |
| Methyl Methanesulfonate >98.0%(GC) | M0369 | 25g | $114 |
| More product size | |||
| Melting point | 20°C |
|---|---|
| Boiling point | 202-203 °C(lit.) |
| Density | 1.3 g/mL at 25 °C(lit.) |
| vapor pressure | 0.8 hPa (59 °C) |
| refractive index |
n |
| Flash point | 220 °F |
| storage temp. | Store below +30°C. |
| solubility | 200g/l |
| form | Liquid |
| color | Colorless to pale yellow |
| Water Solubility | 200 g/L (20 ºC) |
| Merck | 14,6097 |
| BRN | 1098586 |
| Henry's Law Constant | 2.5×100 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| InChI | 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3 |
| InChIKey | MBABOKRGFJTBAE-UHFFFAOYSA-N |
| SMILES | COS(C)(=O)=O |
| CAS DataBase Reference | 66-27-3(CAS DataBase Reference) |
| FDA UNII | AT5C31J09G |
| IARC | 2A (Vol. 7, Sup 7, 71) 1999 |
| NIST Chemistry Reference | Methanesulfonic acid, methyl ester(66-27-3) |
| Proposition 65 List | Methyl Methanesulfonate |
| EPA Substance Registry System | Methyl methanesulfonate (66-27-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H334-H340-H351-H361fd-H373-H411 | |||||||||
| Precautionary statements | P201-P273-P301+P310-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Lungs | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-22-36/37/38-68 | |||||||||
| Safety Statements | 53-26-45-36/37/39 | |||||||||
| RIDADR | UN 2810 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PB2625000 | |||||||||
| F | 21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 2905 19 00 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 Carc. 2 Eye Irrit. 2 Muta. 1B Repr. 2 Skin Irrit. 2 Skin Sens. 1 STOT RE 2 Inhalation |
|||||||||
| Hazardous Substances Data | 66-27-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 orally in Rabbit: 225 mg/kg | |||||||||
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Methyl methanesulfonate price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 129925 | Methyl methanesulfonate 99% | 66-27-3 | 5g | $65.6 | 2026-03-19 | Buy |
| Sigma-Aldrich | 129925 | Methyl methanesulfonate 99% | 66-27-3 | 25g | $158 | 2026-03-19 | Buy |
| Sigma-Aldrich | 8.20775 | Methyl methanesulfonate for synthesis | 66-27-3 | 25mL | $151 | 2022-05-15 | Buy |
| TCI Chemical | M0369 | Methyl Methanesulfonate min. 98.0 % | 66-27-3 | 5G | $22 | 2026-03-19 | Buy |
| TCI Chemical | M0369 | Methyl Methanesulfonate >98.0%(GC) | 66-27-3 | 25g | $114 | 2026-03-19 | Buy |
Methyl methanesulfonate Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Chemical Properties
Clear, colorless to amber liquid.
Uses
Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine.
Uses
Experimentally as mutagen, teratogen, brain carcinogen.
Definition
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.
General Description
Colorless to amber liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.
Fire Hazard
Methyl methanesulfonate is combustible.
Safety Profile
Confirmed carcinogen with carcinogenic and neoplastigenic data. Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human mutation data reported. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of SOx.
Potential Exposure
Research chemical and cancer drug. No longer produced commercially in the United States.
Carcinogenicity
Methyl methanesulfonate is reascarcinogen based on sufficient evi onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition
Waste Disposal
It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Methyl methanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21591 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3982 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from Methyl methanesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-22 | Methyl methanesulfonate
66-27-3
|
US $0.00-0.00 / g | 1g | 99% | 50kg | Dingwang Technology (Wuhan) Co., Ltd. | |
 |
2021-07-13 | Methyl methanesulfonate
66-27-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Methyl methanesulfonate
66-27-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Methyl methanesulfonate
66-27-3
- US $0.00-0.00 / g
- 99%
- Dingwang Technology (Wuhan) Co., Ltd.
-
- Methyl methanesulfonate
66-27-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Methyl methanesulfonate
66-27-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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