N-METHYLBARBITURIC ACID
- CAS No.
- 2565-47-1
- Chemical Name:
- N-METHYLBARBITURIC ACID
- Synonyms
- 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione;1-methylbarbituric acid;Alogliptin-17;N-Methylbarituric Acid;alogliptina impurity 5;alogliptin impurities2;3-METHYLBARBITURIC ACID;N-METHYLBARBITURIC ACID;N-Methylbarituric Acid 1;alogliptin impurities149
- CBNumber:
- CB4119977
- Molecular Formula:
- C5H6N2O3
- Molecular Weight:
- 142.11
- MDL Number:
- MFCD00127915
- MOL File:
- 2565-47-1.mol
| Product description | Number | Pack Size | Price |
| 1-Methylbarbituric Acid | 410072 | 1mg | $523 |
| 1-Methylbarbituric Acid | 410072 | 2.5mg | $871 |
| 1-Methylbarbituric Acid | TRC-M294025-500MG | 500mg | $147 |
| 1-Methylbarbituric Acid | TRC-M294025-250MG | 250mg | $91 |
| 1-Methylbarbituric Acid | TRC-M294025-1G | 1g | $202 |
| More product size | |||
| Melting point | 132 °C |
|---|---|
| Density | 1.379±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | pK1:4.35(＋1) (25°C) |
| color | White to Off-White |
| InChI | InChI=1S/C5H6N2O3/c1-7-4(9)2-3(8)6-5(7)10/h2H2,1H3,(H,6,8,10) |
| InChIKey | DCGGMHIZEAHUJL-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C)C(=O)CC(=O)N1 |
| FDA UNII | 23M53AD2J7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
N-METHYLBARBITURIC ACID price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 410072 | 1-Methylbarbituric Acid | 2565-47-1 | 1mg | $523 | 2026-06-03 | Buy |
| Usbiological | 410072 | 1-Methylbarbituric Acid | 2565-47-1 | 2.5mg | $871 | 2026-06-03 | Buy |
| TRC | TRC-M294025-500MG | 1-Methylbarbituric Acid | 2565-47-1 | 500mg | $147 | 2026-06-03 | Buy |
| TRC | TRC-M294025-250MG | 1-Methylbarbituric Acid | 2565-47-1 | 250mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-M294025-1G | 1-Methylbarbituric Acid | 2565-47-1 | 1g | $202 | 2026-06-03 | Buy |
N-METHYLBARBITURIC ACID Chemical Properties,Uses,Production
Uses
1-Methylbarbituric Acid is an impurity of Trelagliptin. Trelagliptin (Zafatek) is a pharmaceutical drug used for the treatment of type 2 diabetes.
Synthesis
141-82-2
598-50-5
2565-47-1
Acetic anhydride (130 mL, 1.37 mol) was slowly added dropwise to 180 mL of acetic acid solution containing malonic acid (80 g, 0.79 mol) and N-methylurea (50 g, 0.68 mol) at 70 °C. After the dropwise addition was completed, the reaction mixture was warmed up to 90 °C with continuous stirring for 3 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by distillation under reduced pressure and the resulting residue was treated with 350 mL of ethanol to precipitate a pale yellow solid. The solid was purified by recrystallization from ethanol to give 63.1 g of 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione as a final crystalline solid (yield: 65.8%). The melting point was measured to be 131.2-133.1 °C (literature value: 130-131.5 °C).
References
[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 3, p. 594 - 597
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 6, p. 1231 - 1237
[3] Patent: WO2009/73210, 2009, A1. Location in patent: Page/Page column 76
[4] Patent: WO2006/133261, 2006, A2. Location in patent: Page/Page column 30
[5] Patent: WO2007/143705, 2007, A2. Location in patent: Page/Page column 23
N-METHYLBARBITURIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 17259 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
View Lastest Price from N-METHYLBARBITURIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | N-METHYLBARBITURIC ACID
2565-47-1
|
$1.00 | 1KG | 98% HPCL | 10t | Career Henan Chemical Co |
-
- N-METHYLBARBITURIC ACID
2565-47-1
- $1.00
- 98% HPCL
- Career Henan Chemical Co
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