Betadex Sulfobutyl Ether Sodium
- CAS No.
- 182410-00-0
- Chemical Name:
- Betadex Sulfobutyl Ether Sodium
- Synonyms
- SBE-β-CD;CAPTISOL;sodiuM salts;Sulfobutylether-β-Cyclodextrin;b-Cyclodextrin sulfobutyl ether sodium salt;SBEBCD;betadex sulfobuty ether sodium;Sulfobutyl Ether-beta-cyclodextrin Sodium Salt;β-Cyclodextrin, sulfobutyl ethers, sodium salts;Sulfobutyl beta cyclodextrin
- CBNumber:
- CB41208906
- Molecular Formula:
- C70H119Na7O56S7
- Molecular Weight:
- 2242.05
- MDL Number:
- MFCD12032209
- MOL File:
- 182410-00-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 202-204°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water. Insoluble in acetone, methanol, chloroform. |
| form | Solid powder |
| color | White to off white |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions |
PRESERVATIVE SOLVENT SURFACTANT - CLEANSING ABSORBENT |
| InChIKey | WHGYBXFWUBPSRW-CQFZCEJCNA-N |
| FDA UNII | 2PP9364507 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| WGK Germany | WGK 3 |
| HS Code | 2940006000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Skin Sens. 1 |
| REACH Registrations | Active |
Betadex Sulfobutyl Ether Sodium price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | OC59560 | b-Cyclodextrin sulfobutyl ether sodium salt | 182410-00-0 | 10g | $298.2 | 2026-06-04 | Buy |
| Biosynth | OC59560 | b-Cyclodextrin sulfobutyl ether sodium salt | 182410-00-0 | 25g | $596.5 | 2026-06-04 | Buy |
| Biosynth | OC59560 | b-Cyclodextrin sulfobutyl ether sodium salt | 182410-00-0 | 50g | $926 | 2026-06-04 | Buy |
| Biosynth | OC59560 | b-Cyclodextrin sulfobutyl ether sodium salt | 182410-00-0 | 100g | $1493 | 2026-06-04 | Buy |
| Biosynth | OC59560 | b-Cyclodextrin sulfobutyl ether sodium salt | 182410-00-0 | 250g | $2237.5 | 2026-06-04 | Buy |
Betadex Sulfobutyl Ether Sodium Chemical Properties, Uses, Production
Chemical Properties
β-Cyclodextrin, sulfobutyl ethers, sodium salts is a cyclic oligosaccharide containing seven D-(t)- glucopyranose units attached by α(1→4) glucoside bonds. Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Sulfobutylether b-cyclodextrin occurs as a white amorphous powder.
Uses
SBE- β –CD is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs.
Uses
β-Cyclodextrin with sulfobutyl ether groups and sodium ions substituted along the length of the molecule. β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.
Production Methods
Sulfobutylether β-cyclodextrin is prepared by alkylation of bcyclodextrin using 1,4-butane sultone under basic conditions. The degree of substitution in b-cyclodextrin is controlled by the stoichiometric ratio of β-cyclodextrin to sultone used in the process.
Pharmaceutical Applications
Cyclodextrins are crystalline, nonhygroscopic, cyclic oligosaccharides
derived from starch (see Cyclodextrins). Sulfobutylether bcyclodextrin
is an amorphous, anionic substituted b-cyclodextrin
derivative; other substituted cyclodextrin derivatives
are also available.
Sulfobutylether b-cyclodextrin can form noncovalent complexes
with many types of compounds including small organic molecules,
peptides, and proteins. It can also enhance their solubility
and stability in water. The first application of sulfobutylether bcyclodextrin
was in injectable preparations; it can also be used in
oral solid and liquid dosage forms, and ophthalmic,
inhalation, and intranasal formulations. Sulfobutylether bcyclodextrin
can function as an osmotic agent and/or a solubilizer
for controlled-release delivery, and has antimicrobial preservative
properties when present at sufficient concentrations.
The amount of sulfobutylether β-cyclodextrin that may be used
is dependent on the purpose for inclusion in the formulation, the
route of administration, and the ability of the cyclodextrin to
complex with the drug being delivered. The minimum amount
required for solubilization is, in general, a cyclodextrin/drug molar
ratio of approximately 1–5 (the exact ratio being experimentally
determined from complexation data). The maximum use in a
formulation may be limited by physicochemical constraints such as
viscosity (e.g. syringeable concentrations may be considered up to
50% w/v), tonicity, or the total weight and size of solid dosage
forms (e.g. less than a gram in an individual tablet). It may also be
limited by pharmacokinetic/pharmacodynamic (PK/PD) considerations.
As dilution of a cyclodextrin formulation leads to an increase
in the amount of uncomplexed drug, formulations that are not
diluted upon administration, such as ophthalmic formulations, are
sensitive to cyclodextrin concentration. In formulations such as
these, cyclodextrin concentrations greater than the minimum
required for solubilization can reduce the availability of uncomplexed
drug and thereby affect PK/PD expectations by producing
effects such as slower onset, lower Cmax, and bioavailability.
Toxicity evaluation
Sulfobutylether b-cyclodextrin sodium (SBECD) has been associated with toxic effects in the kidney. Doses up to 1500 mg/kg produced no histopathological evidence of toxicity in dog kidneys.
Safety
Sulfobutylether b-cyclodextrin is derived from b-cyclodextrin,
which is nephrotoxic when administered parenterally.
However, studies have shown that sulfobutylether bcyclodextrin
is well tolerated at high doses, when administered via
intravenous bolus injections, orally, and by inhalation. Up to
9 g/day may be administered by IV infusion in a licensed
voriconazole formulation. The safety following high doses of
sulfobutylether β-cyclodextrin intravenous administration in
humans is continually being investigated.
Sulfobutylether β-cyclodextrin has been subjected to an extensive
battery of in vitro and in vivo genotoxicity and pharmacological
evaluations. No genotoxic or mutagenic changes were
observed with sulfobutylether β-cyclodextrin administration. Sulfobutylether
β-cyclodextrin is biocompatible and exhibits no
pharmacological activity. It is rapidly eliminated unmetabolized
when administered intravenously.
storage
Sulfobutylether b-cyclodextrin(182410-00-0) is stable in the solid state and should be protected from high humidity. It should be stored in a tightly sealed container in a cool, dry place.
It will reversibly take up moisture without any effect on the appearance of the material at humidities up to 60% RH. Equilibration at RH values above 60% will result in deliquescence. Once in this state, the material can be dried, but will give a glasslike product. This water absorption behavior is typical of amorphous hygroscopic materials.
Sulfobutylether b-cyclodextrin is stable in aqueous solutions at values above about pH 1. It can degrade in highly acidic (pH < 1) solutions, particularly at elevated temperatures, producing the ring-opened form, followed by hydrolysis of the a(1-4) glucoside bonds.
Sulfobutylether b-cyclodextrin solutions may be autoclaved.
Incompatibilities
The preservative activity of benzalkonium chloride is reduced in the presence of sulfobutylether b-cyclodextrin.
Regulatory Status
Sulfobutylether β-cyclodextrin is included in IV and IM injectable products currently approved and marketed in the USA, Europe, and Japan. It is included in the FDA Inactive Ingredients Database for IM and IV use. Its use by other routes, including SC, oral, inhalation, nasal and ophthalmic, is being evaluated in clinical studies.
Betadex Sulfobutyl Ether Sodium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Qianhui Biological Technology Co., Ltd | 0533-3780068 18653397376 | admin@zbqianhui.cn | China | 15 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Hefei QiChang Biological Technology Co., Ltd. | 18019964904; 17756579152 | liuchun.0228@163.com | China | 65 | 58 |
| Tocopharm Co., Ltd. | +86-021-69895597 13776836200 +86-13776836200 | tocopharm@gmail.com | China | 206 | 55 |
| Shanghai Genriver Pharmaceutical Co., Ltd. | 21-13482015261-883 13482015261 | info@genriverpharm.com | China | 444 | 58 |
| HAINAN POLY PHARMCEUTICAL CO. LTD | +86-0571-89385087 18167156872 | gaoying@hnpoly.com | China | 29 | 58 |
| Shanghai xinchenfa Chemical Technology Co.,Ltd | 021-13564487020 13564487020 | 3546809660@qq.com | China | 498 | 58 |
| Shandong Zhiyuan Biotechnology Co., Ltd. | 0543-2616568 13562317646 | zhiyuansw@vip.163.com | China | 57 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
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View Latest Price from Betadex Sulfobutyl Ether Sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Betadex sulfobutyl ether sodium
182410-00-0
|
1KG | 95%-105%; USP43-NF38; Injection grade | 100kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-18 | β-Cyclodextrin, sulfobutyl ethers, sodium salts
182410-00-0
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-16 | Betadex Sulfobutyl Ether Sodium
182410-00-0
|
$10.00 | 1kg | 99% | 20 tons | Nantong Provichem Biotech Co., Ltd. |
-
- Betadex sulfobutyl ether sodium
182410-00-0
- $0.00
- 95%-105%; USP43-NF38; Injection grade
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- β-Cyclodextrin, sulfobutyl ethers, sodium salts
182410-00-0
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Betadex Sulfobutyl Ether Sodium
182410-00-0
- $10.00
- 99%
- Nantong Provichem Biotech Co., Ltd.
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