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ChemicalBook >> CAS DataBase List >>Ethanone, 2-chloro-1-(3-indolyl)-

Ethanone, 2-chloro-1-(3-indolyl)-

Ethanone, 2-chloro-1-(3-indolyl)- Structure
Ethanone, 2-chloro-1-(3-indolyl)- structure
CAS No.
28755-03-5
Chemical Name:
Ethanone, 2-chloro-1-(3-indolyl)-
Synonyms
3CAI;3CAI >=95% (HPLC);3CAI, 10 mM in DMSO;3-chloroacetylindole;Akt Inhibitor XIX, 3CAI;Chloromethyl indol-3-yl ketone;3-(Chloroacetyl)-1H-indole 95%;2-Chloro-1-(3-Indolyl)-Ethanone;Ethanone, 2-chloro-1-(3-indolyl)-;Ethanone, 2-chloro-1H-indol-1-yl-
CBNumber:
CB41247653
Molecular Formula:
C10H8ClNO
Molecular Weight:
193.63
MDL Number:
MFCD00464796
MOL File:
28755-03-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-29 11:56:07
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Ethanone, 2-chloro-1-(3-indolyl)- Properties

Melting point 212-214 °C(Solv: ethyl ether (60-29-7))
Boiling point 379.1±17.0 °C(Predicted)
Density 1.337±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: soluble5mg/mL, clear
form powder
pka 15.08±0.30(Predicted)
color yellow to brown
InChI 1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2
InChIKey LLZQFAXTCYDVTR-UHFFFAOYSA-N
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
WGK Germany  3
HS Code  2933998090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

Ethanone, 2-chloro-1-(3-indolyl)- price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 124037 Akt Inhibitor XIX, 3CAI 28755-03-5 25mg $195 2023-01-07 Buy
Cayman Chemical 14303 3CAI ≥95% 28755-03-5 250mg $103 2026-04-30 Buy
Cayman Chemical 14303 3CAI ≥95% 28755-03-5 500mg $183 2026-04-30 Buy
Cayman Chemical 14303 3CAI ≥95% 28755-03-5 1g $303 2026-04-30 Buy
TRC TRC-C382623-5G 3-(Chloroacetyl)indole 28755-03-5 5g $1250 2026-06-03 Buy
Product number Packaging Price Buy
124037 25mg $195 Buy
14303 250mg $103 Buy
14303 500mg $183 Buy
14303 1g $303 Buy
TRC-C382623-5G 5g $1250 Buy

Ethanone, 2-chloro-1-(3-indolyl)- Chemical Properties, Uses, Production

Uses

3-(Chloroacetyl)indole is a reagent used in organic synthesis. Used in the preparation of 1,2-dihydroazepino[4,5-b]indoles.

Biological Activity

3cai is a potent allosteric and specific inhibitor of akt, which directly binds with akt1 or akt2 in an atp noncompetitive manner and shows 60% inhibition of akt1 kinase activity at 1 μm [1]. the serine/threonine kinase akt includes three members, akt1, akt2, and akt3. akt plays a critical role in promoting transformation and chemoresistance through inducing proliferation and inhibiting apoptosis. therefore, akt is regarded as a potential target for cancer therapy.

in vitro

3cai (1 and 4 μm) significantly inhibited akt1 kinase activity and decreased expression of akt direct downstream targets including mtor and gsk3β, respectively. 3cai (4 μm) efficiently induced growth inhibition and apoptosis in hct116 or hct29 colon cancer cells [1].

in vivo

3cai (30 mg/kg, oral administration) significantly suppressed colon cancer growth in an in vivo xenograft mouse model and inhibited the expression of akt-target protein such as mtor and gsk3βin hct116 colon tumor tissues [1].

target

akt

IC 50

1 μm

References

1. kim dj, reddy k, kim mo, li y, nadas j, cho yy, et al. (3-chloroacetyl)-indole, a novel allosteric akt inhibitor, suppresses colon cancer growth in vitro and in vivo. cancer prev res (phila). 2011;4(11):1842-51.

Ethanone, 2-chloro-1-(3-indolyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Hydroxy-1-(1H-indol-3-yl)ethanone

Ethanone, 2-chloro-1-(3-indolyl)- Suppliers

Global Suppliers ( 88)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4904 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Musechem +1-800-259-7612 info@musechem.com United States 4648 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 sales@rrkchem.com China 57336 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
MedChemexpress LLC 58
Shanghai Raise Chemical Technology Co.,Ltd 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
BOC Sciences 65
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Musechem 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58

View Latest Price from Ethanone, 2-chloro-1-(3-indolyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3CAI pictures 2026-08-29 3CAI
28755-03-5
 $30.00-76.00 99.62% 10g TargetMol Chemicals Inc.
3CAI pictures 2026-08-08 3CAI
28755-03-5
 $30.00-76.00 99.62% 10g TargetMol Chemicals Inc.
Ethanone, 2-chloro-1-(3-indolyl)- pictures 2026-06-30 Ethanone, 2-chloro-1-(3-indolyl)-
28755-03-5
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
  • 3CAI pictures
  • 3CAI
    28755-03-5
  • $30.00-76.00
  • 99.62%
  • TargetMol Chemicals Inc.
  • 3CAI pictures
  • 3CAI
    28755-03-5
  • $30.00-76.00
  • 99.62%
  • TargetMol Chemicals Inc.

Ethanone, 2-chloro-1-(3-indolyl)- Spectrum

Ethanone, 2-chloro-1-(3-indolyl)-(28755-03-5)1HNMR

28755-03-5 (Ethanone, 2-chloro-1-(3-indolyl)-) Related Search:

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Ethanone, 2-chloro-1-(3-indolyl)- 3-chloroacetylindole 2-chloro-1-(1H-indol-3-yl)ethanone(SALTDATA: FREE) 2-Chloro-1-(1H-indol-3-yl)ethan-1-one, 3-(2-Chloroethanoyl)-1H-indole 3CAI Chloromethyl indol-3-yl ketone Ethanone, 2-chloro-1-(1H-indol-3-yl)- Ethanone, 2-chloro-1H-indol-1-yl- 2-Chloro-1-(3-Indolyl)-Ethanone Akt Inhibitor XIX, 3CAI Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem 3-(Chloroacetyl)-1H-indole 95% 3CAI >=95% (HPLC) Inhibitor,3CAI,inhibit,Akt,Protein kinase B,PKB 3CAI, 10 mM in DMSO 28755-03-5