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Suzetrigine

Suzetrigine Structure
Suzetrigine structure
CAS No.
2649467-58-1
Chemical Name:
Suzetrigine
Synonyms
VX-548;suzetrigin;Suzetrigine (VX-548);(2S,3S,4S,5R)-N-(2-((aminooxy)carbonyl)pyridin-4-yl)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide;Suzetrigine;Suzetrigine1;FANDACHEM VX-548;SUZETRIGINE/VAX548;VX-548（Suzetrigine）;FANDACHEM Suzetrigine
CBNumber:
CB412520545
Molecular Formula:
C21H20F5N3O4
Molecular Weight:
473.4
MDL Number:
MOL File:
2649467-58-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:02:32
Product description Number Pack Size Price
Suzetrigine ≥95% 40799 1mg $86
Suzetrigine ≥95% 40799 5mg $215
Suzetrigine ≥95% 40799 10mg $344
Suzetrigine 99.98% CS-0641183 5mg $206
Suzetrigine 99.98% CS-0641183 10mg $325
Request For Quotation

Suzetrigine Properties

Boiling point 591.8±50.0 °C(Predicted)
Density 1.399±0.06 g/cm3(Predicted)
solubility Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml
form Solid
pka 11.74±0.70(Predicted)
color White to light yellow
InChIKey XSQUJFKRXZMOKA-KRZZIQMTNA-N
SMILES C([C@@H]1O[C@@](C)(C(F)(F)F)[C@@H](C)[C@H]1C1C=CC(F)=C(F)C=1OC)(=O)NC1=CC=NC(C(=O)N)=C1 |&1:1,3,9,11,r|
FDA UNII LOG73M21H5

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Suzetrigine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 40799 Suzetrigine ≥95% 2649467-58-1 1mg $86 2026-04-30 Buy
Cayman Chemical 40799 Suzetrigine ≥95% 2649467-58-1 5mg $215 2026-04-30 Buy
Cayman Chemical 40799 Suzetrigine ≥95% 2649467-58-1 10mg $344 2026-04-30 Buy
ChemScene CS-0641183 Suzetrigine 99.98% 2649467-58-1 5mg $206 2026-06-04 Buy
ChemScene CS-0641183 Suzetrigine 99.98% 2649467-58-1 10mg $325 2026-06-04 Buy
Product number Packaging Price Buy
40799 1mg $86 Buy
40799 5mg $215 Buy
40799 10mg $344 Buy
CS-0641183 5mg $206 Buy
CS-0641183 10mg $325 Buy

Suzetrigine Chemical Properties,Uses,Production

Description

Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8; IC50 = 0.7 nM for the human channel).1 It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).WARNING This product is not for human or veterinary use.

Synthesis

The synthesis of Suzetrigine (VX-548) revolves around the highly stereoselective construction of its tetrahydropyran core. A typical synthetic route begins with a chiral starting material (e.g., a chiral epoxide) that undergoes a stereoselective addition reaction with a fluoroaryllithium reagent, introducing a phenyl group and a trifluoromethyl group. Subsequently, a nucleophilic cyclization reaction forms the crucial tetrahydropyran ring, thus determining the correct configuration of the four stereocenters. Subsequent steps involve standard organotransformation reactions, such as cross-coupling reactions (e.g., the Suzuki coupling reaction), to introduce the pyridine moiety, ultimately yielding the final Suzetrigine product via deprotection and salt formation.

References

[1] JIM JONES. Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.[J]. New England Journal of Medicine, 2023, 389 5: 393-405. DOI: 10.1056/nejmoa2209870

Suzetrigine Preparation Products And Raw materials

Raw materials

Preparation Products

Suzetrigine Suppliers

Global( 163)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Hong Kongda Chemical Co.,LTD 		+86-18753193522 +86-18753193522 sales@hkdchem.com China 97 58
Chongqing jooe co., ltd
+undefined86-15223382610 info@jooe.com China 15976 58
.GZ HONESTCHEM CO.,LTD 		+8615013270415 honestchemical@foxmail.com China 300 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 sales@sjar-tech.com China 529 58
Moxin Chemicals 		+86-17320513646 +8617320513646 anna@molcoo.com China 10000 58
Rongchuang International 		+8613175533356 kevin@rongchuangintl.com China 272 58
Jinan Jianfeng Chemical Co., Ltd 		+86-0531-88110457 +8615562555968 info@pharmachemm.com China 310 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		21-38751876 +8615000076078 info@rochipharma.com China 505 58
Supplier Advantage
Jinan Hong Kongda Chemical Co.,LTD 		58
Chongqing jooe co., ltd
58
.GZ HONESTCHEM CO.,LTD 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58
Moxin Chemicals 		58
Rongchuang International 		58
Jinan Jianfeng Chemical Co., Ltd 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Shanghai Rochi Pharmaceutical Co.,Ltd. 		58

View Lastest Price from Suzetrigine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SUZETRIGINE pictures 2026-06-04 SUZETRIGINE
2649467-58-1
 $1.00 300g 99.8% 20 TONS .GZ HONESTCHEM CO.,LTD
Suzetrigine（VX-548） pictures 2026-06-04 Suzetrigine（VX-548）
2649467-58-1
 1g 99% 5000kg Jinan Jianfeng Chemical Co., Ltd
Suzetrigine pictures 2026-06-04 Suzetrigine
2649467-58-1
 1g 99% 9999 Rongchuang International
  • SUZETRIGINE pictures
  • SUZETRIGINE
    2649467-58-1
  • $1.00
  • 99.8%
  • .GZ HONESTCHEM CO.,LTD
  • Suzetrigine pictures
  • Suzetrigine
    2649467-58-1
  • $0.00
  • 99%
  • Rongchuang International

Suzetrigine Spectrum

Suzetrigine(2649467-58-1)1HNMR
2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]- Suzetrigine VX-548（Suzetrigine） 4-[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido]picolinamide (2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide SUZETRIGINE/VAX548 FANDACHEM VX-548 FANDACHEM Suzetrigine VX-548/Suzetrigine FANDACHEM Suzetrigine / VX-548 FANDACHEM VX-548/Suzetrigine MANUFACTURER FANDACHEM Buy VX-548/Suzetrigine from FANDACHEM VX-548/Suzetrigine FOR SALE PURCHASE VX-548/Suzetrigine VX-548/Suzetrigine DISTRIBUTOR VX-548/Suzetrigine PRICE COST "2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4 -difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]ami" Suzetrigine，PhEur/USP(DMF) Suzetrigine1 4-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-Pyridinecarboxamide suzetrigine impurity API (2S,3S,4S,5R)-N-(2-((aminooxy)carbonyl)pyridin-4-yl)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide Suzetrigine (VX-548) suzetrigin VX-548 2649467-58-1 SUZETRIGINE API