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ChemicalBook >> CAS DataBase List >>Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel-

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel-

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- Structure
Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- structure
CAS No.
80943-40-4
Chemical Name:
Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel-
Synonyms
DL-erythro-PDMP (hydrochloride);Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel-
CBNumber:
CB412805602
Molecular Formula:
C23H38N2O3.ClH
Molecular Weight:
427.02
MDL Number:
MOL File:
80943-40-4.mol
MSDS File:
SDS
Last updated:2025-04-17 18:22:24
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Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- Properties

solubility DMF: 25 mg/mL; DMSO: 30 mg/mL; Ethanol: 50 mg/mL; Ethanol:PBS(pH 7.2) (1:5): 0.05 mg/mL
form A solid
color White to off-white

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22676 DL-erythro-PDMP (hydrochloride) ≥98% 80943-40-4 100mg $235 2026-04-30 Buy
ChemScene CS-0655338 D,L-erythro-PDMP (hydrochloride) 98.45% 80943-40-4 5mg $108 2026-06-04 Buy
ChemScene CS-0655338 D,L-erythro-PDMP (hydrochloride) 98.45% 80943-40-4 10mg $173 2026-06-04 Buy
aablocks AA02011D DL-erythro-PDMP (hydrochloride) ≥98% 80943-40-4 100mg $235 2026-06-01 Buy
Arctom HY-116392H D,L-erythro-PDMP hydrochloride 98.45% 80943-40-4 5mg $95 2026-05-26 Buy
Product number Packaging Price Buy
22676 100mg $235 Buy
CS-0655338 5mg $108 Buy
CS-0655338 10mg $173 Buy
AA02011D 100mg $235 Buy
HY-116392H 5mg $95 Buy

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- Chemical Properties, Uses, Production

Description

DL-erythro-PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP : D-erythro-(1S,2R)-PDMP and L-erythro-(1R,2S)-PDMP.1,2 It protects glucosylceramide (GlcCer) synthase from degradation and increases the level of ceramide in MDCK cells when used at a concentration of 40 μM.2 Unlike DL-threo-PDMP, DL-erythro-PDMP does not inhibit GlcCer synthase, but it does inhibit UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes when used at a concentration of 100 μM.3 It inhibits the growth of isolated rabbit skin fibroblasts when used at a concentration of 50 μM but is cytotoxic at concentrations higher than 50 μM.4 [Matreya, LLC. Catalog No. 1755]

Uses

D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase[1][2].

References

1. Vunnam, R.R., and Radin, N.S. Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain Chem. Phys. Lipids 26(3),265-278(1980).
2. Abe, A., Radin, N.S., and Shayman, J.A. Induction of glucosylceramide synthase by synthase inhibitors and ceramide Biochim. Biophys. Acta 1299(3),333-341(1996).
3. Inokuchi, J.i., and Radin, N.S. Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase J. Lipid Res. 28(5),565-571(1987).
4. Uemura, K., Sugiyama, E., Tamai, C., et al. Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts J. Biochem. 108(4),525-530(1990).

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- Preparation Products And Raw materials

Raw materials

Preparation Products

Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- Suppliers

Global Suppliers ( 5)
Supplier Tel Email Country ProdList Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

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Decanamide, N-[(1R,2S)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1), rel- DL-erythro-PDMP (hydrochloride) 80943-40-4