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ChemicalBook >> CAS DataBase List >>5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Structure
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE structure
CAS No.
256414-75-2
Chemical Name:
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
Synonyms
SW2871;SEW 2871;BUTTPARK 82\12-95;SEW 2871, S1P1 agonist;SEW2871, 10 mM in DMSO;S1P? Receptor Agonist, SEW2871;SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST;S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem;5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE;5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
CBNumber:
CB4131568
Molecular Formula:
C20H10F6N2OS
Molecular Weight:
440.36
MDL Number:
MFCD00096600
MOL File:
256414-75-2.mol
MSDS File:
SDS
Last updated:2026-03-15 20:18:04
Product description Number Pack Size Price
SEW2871 ≥98% (HPLC), solid S3944 1mg $310
SEW2871 ≥98% 10006440 5mg $32
SEW2871 ≥98% 10006440 10mg $61
SEW2871 ≥98% (HPLC), solid S3944 5mg $1180
SEW2871 ≥98% 10006440 25mg $139
More product size
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5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Properties

Melting point 94.5-95.3 °C
Boiling point 490.3±55.0 °C(Predicted)
Density 1.415±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 17 mg/mL
pka -3.48±0.43(Predicted)
form solid
color white
InChI 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
InChIKey OYMNPJXKQVTQTR-UHFFFAOYSA-N
SMILES FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
UNSPSC Code 12352211
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2934999090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
NFPA 704
1
2 0

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S3944 SEW2871 ≥98% (HPLC), solid 256414-75-2 1mg $310 2026-03-19 Buy
Cayman Chemical 10006440 SEW2871 ≥98% 256414-75-2 5mg $32 2024-03-01 Buy
Cayman Chemical 10006440 SEW2871 ≥98% 256414-75-2 10mg $61 2024-03-01 Buy
Sigma-Aldrich S3944 SEW2871 ≥98% (HPLC), solid 256414-75-2 5mg $1180 2026-03-19 Buy
Cayman Chemical 10006440 SEW2871 ≥98% 256414-75-2 25mg $139 2024-03-01 Buy
Product number Packaging Price Buy
S3944 1mg $310 Buy
10006440 5mg $32 Buy
10006440 10mg $61 Buy
S3944 5mg $1180 Buy
10006440 25mg $139 Buy

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Chemical Properties,Uses,Production

Description

Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.

Uses

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.

Uses

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.

Definition

ChEBI: 5-[4-phenyl-5-(trifluoromethyl)-2-thiophenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole is an oxadiazole and a ring assembly.

Biological Activity

Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .

Biochem/physiol Actions

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.

storage

Store at RT

References

[1] MICHAEL J KLUK  Timothy H. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2002, 1582 1: Pages 72-80. DOI: 10.1016/s1388-1981(02)00139-7
[2] M GERMANA SANNA. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate.[J]. The Journal of Biological Chemistry, 2004, 279 14: 13839-13848. DOI: 10.1074/jbc.m311743200

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Suppliers

Global( 122)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32469 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 24597 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Soochow Chirally Material Science and Technology Co.,Ltd 		+86-51266834346 +86-17751128648 sales@krl-tech.com China 942 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Soochow Chirally Material Science and Technology Co.,Ltd 		58
Amadis Chemical Company Limited 		58

View Lastest Price from 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SEW?2871 pictures 2026-03-14 SEW?2871
256414-75-2
 US $48.00-153.00 / mg 99.87% 10g TargetMol Chemicals Inc.
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE pictures 2020-01-10 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
256414-75-2
 US $0.01 / KG 1KG 98%; 99% 500g;1kg； 25kg Career Henan Chemical Co
  • SEW?2871 pictures
  • SEW?2871
    256414-75-2
  • US $48.00-153.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Spectrum

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE(256414-75-2)MS5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE(256414-75-2)1HNMR

256414-75-2(5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE)Related Search:

Benzotribromide 2,4,6-Trimethylaniline 2-(TRIFLUOROMETHYL)THIOPHENE 5-METHYL-3-PHENYL-1,2,4-OXADIAZOLE 3,5-DIMETHYL-1,2,4-OXADIAZOLE
2,3,5-Trimethylthiophene 3-PHENYLTHIOPHENE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

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SEW 2871 SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST SW2871 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE BUTTPARK 82\12-95 SEW-2871, 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole 5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole S1P? Receptor Agonist, SEW2871 S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem 1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- SEW 2871, S1P1 agonist SEW2871, 10 mM in DMSO 256414-75-2 C20H10F6N2OS Lysophospholipid receptor and related Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds