CREBtide
- CAS No.
- 149155-45-3
- Chemical Name:
- CREBtide
- Synonyms
- CREBtide TFA;CREBtide [KRREILSRRPSYR] - 5 mg;L-Arginine, L-lysyl-L-arginyl-L-arginyl-L-α-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-seryl-L-tyrosyl-
- CBNumber:
- CB41319905
- Molecular Formula:
- C73H129N29O19
- Molecular Weight:
- 1716.99
- MDL Number:
- MOL File:
- 149155-45-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
CREBtide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0910934 | CREBtide (TFA) 98.72% | 5mg | $238 | 2026-06-04 | Buy | |
| ChemScene | CS-0910934 | CREBtide (TFA) 98.72% | 10mg | $379 | 2026-06-04 | Buy | |
| ChemScene | CS-0045222 | CREBtide 98.33% | 149155-45-3 | 5mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-0045222 | CREBtide 98.33% | 149155-45-3 | 10mg | $379 | 2026-06-04 | Buy |
| aablocks | AA00AXIP | CREBtide ≥98% | 149155-45-3 | 1mg | $125 | 2026-05-28 | Buy |
CREBtide Chemical Properties, Uses, Production
Uses
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate.
Biological Activity
CREBtide is a synthetic 13 amino acid peptide that acts as a PKA substrate.
in vitro
delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent K m of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (K m =39 μM), the synthetic peptide substrate most often employed for cAK measurement. The V max values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent K m of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the V max value is 3.2 mumol/(min.mg). Both delta -CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide.
target
PKA
References
[1] Wu J, et al. A microPLC-based approach for determining kinase-substrate specificity. Assay Drug Dev Technol. 2007 Aug;5(4):559-66. DOI:10.1089/adt.2007.072
[2] Colbran JL, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82. DOI:10.1139/o92-174
[3] Harum KH, et al. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology. 2001 Jan 23;56(2):207-14. DOI:10.1212/wnl.56.2.207
[4] Peng J, et al. Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction. J Neuroinflammation. 2011 Apr 8;8:28. DOI:10.1186/1742-2094-8-28
CREBtide Preparation Products And Raw materials
Raw materials
Preparation Products
CREBtide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2447 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14072 | 58 |
| Ontores Biotech | 0571-88760729 18072970094 | supports@ontorespeptide.com | China | 2696 | 58 |
| Nanjing Yuanpeptide Biotech Co.，Ltd. | 13357818155 | linhui@yuan-peptide.com | China | 2901 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
